Progress of Electrospun Nanofibrous Carriers for Modifications to Drug Release Profiles

Journal of Functional Biomaterials, Год журнала: 2022, Номер 13(4), С. 289 - 289

Опубликована: Дек. 9, 2022

Electrospinning is an advanced technology for the preparation of drug-carrying nanofibers that has demonstrated great advantages in biomedical field. Electrospun nanofiber membranes are widely used field drug administration due to their such as large specific surface area and similarity extracellular matrix. Different electrospinning technologies can be prepare different structures, those with a monolithic structure, core–shell Janus or porous structure. It also possible controlled-release functions, sustained release, delayed biphasic targeted release. This paper elaborates on drug-loaded using various concludes mechanisms behind controlled release drugs.

Язык: Английский

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The Applications of Ferulic-Acid-Loaded Fibrous Films for Fruit Preservation

Polymers, Год журнала: 2022, Номер 14(22), С. 4947 - 4947

Опубликована: Ноя. 16, 2022

The aim of this study was to develop a novel ultrathin fibrous membrane with core-sheath structure as an antioxidant food packaging membrane. prepared by coaxial electrospinning, and the release active substances regulated its special structure. Ferulic acid (FA) incorporated into electrospun zein/polyethylene oxide fibers ensure their synergistic properties. We found that had good morphology smooth surface. internal stable, three materials we used were compatible. For different loading positions, it observed core layer ferulic-acid-loaded sustained action, while sheath pre-burst action. Finally, apples selected for using membranes simulate practical applications. effective in reducing water loss apple quality loss, well extending shelf life. According these experiments, FA-loaded zein/PEO electrospinning fiber can be will also undergo more improvements future.

Язык: Английский

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Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Polymers, Год журнала: 2023, Номер 15(4), С. 921 - 921

Опубликована: Фев. 12, 2023

Electrospun porous nanofibers have gained a lot of interest recently in various fields because their adjustable structure, high specific surface area, and large number active sites, which can further enhance the performance materials. This paper provides an overview common polymers, preparation, applications electrospun nanofibers. Firstly, polymers commonly used to construct structures main pore-forming methods by electrospinning, namely template method phase separation method, are introduced. Secondly, recent air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound wave absorption, flame retardant, heat insulation reviewed. Finally, challenges possible research directions for future study discussed.

Язык: Английский

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Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance

Advanced Composites and Hybrid Materials, Год журнала: 2023, Номер 6(6)

Опубликована: Окт. 17, 2023

Язык: Английский

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Electrosprayed Stearic-Acid-Coated Ethylcellulose Microparticles for an Improved Sustained Release of Anticancer Drug

Gels, Год журнала: 2023, Номер 9(9), С. 700 - 700

Опубликована: Авг. 29, 2023

Sustained release is highly desired for "efficacious, safe and convenient" drug delivery, particularly those anticancer molecules with toxicity. In this study, a modified coaxial electrospraying process was developed to coat hydrophobic lipid, i.e., stearic acid (SA), on composites composed of the tamoxifen citrate (TC) insoluble polymeric matrix ethylcellulose (EC). Compared electrosprayed TC-EC composite microparticles M1, SA-coated hybrid M2 were able provide an improved TC sustained-release profile. The 30% 90% loaded time periods extended 3.21 h 19.43 M2, respectively, which significantly longer than provided by M1 (0.88 9.98 h, respectively). morphology, inner structure, physical state, compatibility components particles disclosed through SEM, TEM, XRD, FTIR. Based analyses, mechanism multiple factors co-acting suggested, include reasonable selections organizations lipid excipient, blank SA shell loading, regularly round shape, also high density. reported protocols pioneered brand-new manner developing sustained delivery hybrids combination cellulose gels using electrospraying.

Язык: Английский

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Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Macromolecular Materials and Engineering, Год журнала: 2023, Номер 309(4)

Опубликована: Ноя. 23, 2023

Abstract In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by novel spinneret, is homemade conducting processes. The types electrospun nanofibers E1, electrosprayed microparticles E2, core‐shell E3. SEM TEM results indicate that they have anticipated morphologies inner structures. X‐ray diffraction Fourier Transform Infrared verify KET mainly amorphous in all composites due its fine compatibility with HPMC. vitro tests demonstrate rapid release performances has an order E3>E1>E2≫KET powders. mechanisms suggested advantages compared. super performance E3 furnishing attributed synergistic action small size (of shell thickness), high porosity, state drug, solubility nanostructures can support development nano delivery systems (DDSs) through tailoring spatial distribution molecules within products.

Язык: Английский

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Recent Progress of Electrospun Herbal Medicine Nanofibers

Biomolecules, Год журнала: 2023, Номер 13(1), С. 184 - 184

Опубликована: Янв. 16, 2023

Herbal medicine has a long history of medical efficacy with low toxicity, side effects and good biocompatibility. However, the bioavailability extract raw herbs bioactive compounds is poor because their water solubility. In order to overcome solubility issues, electrospinning technology can offer delivery alternative resolve them. The electrospun fibers have advantages high specific surface area, porosity, excellent mechanical strength flexible structures. At same time, various natural synthetic polymer-bound mimic extracellular matrix applications in different fields. this paper, development polymers used for incorporating herbal into nanofibers are reviewed. Finally, recent progress these biomedical (drug delivery, wound dressing, tissue engineering) food fields along future prospects discussed.

Язык: Английский

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Tri-Layer Core–Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole

Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2561 - 2561

Опубликована: Окт. 31, 2023

Polymers are the backbone of drug delivery. Electrospinning has greatly enriched strategies that have been explored for developing novel delivery systems using polymers during past two decades. In this study, four different kinds polymers, i.e., water-soluble polymer poly (vinyl alcohol) (PVA), insoluble poly(ε-caprolactone) (PCL), Eudragit RL100 (ERL100) and pH-sensitive S100 (ES100) were successfully converted into types tri-layer tri-polymer core-shell fibers through bi-fluid coaxial electrospinning. During process, model metronidazole (MTD) was loaded shell working fluid, which an emulsion. The micro-formation mechanism from emulsion electrospinning proposed. Scanning electron microscope transmission evaluations verified linear morphology resultant their obvious multiple-chamber structures. X-ray diffraction Fourier transform infrared spectroscopy measurements demonstrated MTD presented in amorphous state compatible with three polymeric matrices. vitro dissolution tests could act a synergistic manner prolonged sustained-release profile gut. controlled-release mechanisms suggested detail. protocols reported here pioneer new route creating structure both aqueous organic solvents, strategy advanced sophisticated profiles.

Язык: Английский

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Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review

Biomolecules, Год журнала: 2024, Номер 14(7), С. 789 - 789

Опубликована: Июль 3, 2024

Alginate is a natural polymer with good biocompatible properties and potential polymeric material for the sustainable development replacement of petroleum derivatives. However, non-spinnability pure alginate solutions has hindered expansion applications. With continuous electrospinning technology, synthetic polymers, such as PEO PVA, are used co-spinning agents to increase spinnability alginate. Moreover, coaxial, parallel Janus, tertiary other diverse novel electrospun fiber structures prepared by multi-fluid have found new breakthrough problem poor spinning polymers. Meanwhile, effectively achieve multiple release modes drugs. The powerful combination electrostatic widely in many biomedical fields, tissue engineering, regenerative bioscaffolds, drug delivery, research fever continues climb. This particularly true controlled delivery aspect review provides brief overview alginate, introduces advances spinning, highlights progress alginate-based nanofibers achieving various modes, pulsed release, sustained biphasic responsive targeted release.

Язык: Английский

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A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Ноя. 15, 2023

Bacterial prostatitis is a challenging condition to treat with traditional dosage forms. Physicians often prescribe variety of forms different administration methods, which fail provide an efficient and convenient mode drug delivery. The aim this work was develop new type hybrid material incorporating both electrosprayed core-shell microparticles electrospun nanofibers. A Chinese medicine (Ningmitai, NMT) Western (ciprofloxacin, CIP) were co-encapsulated within designed be released in separately controlled manner. Utilizing polyvinylpyrrolidone (PVP) as hydrophilic filament-forming polymer pH-sensitive Eudragit ® S100 (ES100) the particulate polymeric matrix, combined electrohydrodynamic atomization (EHDA) method comprising coaxial electrospraying blending electrospinning, used create hybrids single-step straightforward series characterization methods conducted analyze working process its final products. Scanning electron microscopy transmission revealed that EHDA comprised CIP-PVP nanofibers NMT-ES100 microparticles. Multiple confirmed rapid release CIP sustained NMT. antibacterial experiments indicated exhibited more potent effect against Escherichia coli dh5α Bacillus subtilis Wb800 than either separate or amalgamation fibrous nanomedicine micromedicine can expand horizon types medicines. integration electrospinning provides approach fabrication. By combining soluble polymers hybrids, we ensure sequential NMT for potential synergistic therapy bacterial prostatitis.

Язык: Английский

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