Polymers,
Год журнала:
2023,
Номер
15(10), С. 2237 - 2237
Опубликована: Май 9, 2023
Colon-targeted
drug
delivery
is
gradually
attracting
attention
because
it
can
effectively
treat
colon
diseases.
Furthermore,
electrospun
fibers
have
great
potential
application
value
in
the
field
of
their
unique
external
shape
and
internal
structure.
In
this
study,
a
core
layer
hydrophilic
polyethylene
oxide
(PEO)
anti-colon-cancer
curcumin
(CUR),
middle
ethanol,
sheath
natural
pH-sensitive
biomaterial
shellac
were
used
modified
triaxial
electrospinning
process
to
prepare
beads-on-the-string
(BOTS)
microfibers.
A
series
characterizations
carried
out
on
obtained
verify
process-shape/structure-application
relationship.
The
results
scanning
electron
microscopy
transmission
indicated
BOTS
core-sheath
X-ray
diffraction
that
was
an
amorphous
form.
Infrared
spectroscopy
revealed
good
compatibility
components
fibers.
vitro
release
microfibers
provide
colon-targeted
zero-order
release.
Compared
linear
cylindrical
microfibers,
prevent
leakage
drugs
simulated
gastric
fluid,
they
intestinal
fluid
beads
act
as
reservoirs.
Journal of Functional Biomaterials,
Год журнала:
2022,
Номер
13(4), С. 289 - 289
Опубликована: Дек. 9, 2022
Electrospinning
is
an
advanced
technology
for
the
preparation
of
drug-carrying
nanofibers
that
has
demonstrated
great
advantages
in
biomedical
field.
Electrospun
nanofiber
membranes
are
widely
used
field
drug
administration
due
to
their
such
as
large
specific
surface
area
and
similarity
extracellular
matrix.
Different
electrospinning
technologies
can
be
prepare
different
structures,
those
with
a
monolithic
structure,
core–shell
Janus
or
porous
structure.
It
also
possible
controlled-release
functions,
sustained
release,
delayed
biphasic
targeted
release.
This
paper
elaborates
on
drug-loaded
using
various
concludes
mechanisms
behind
controlled
release
drugs.
Polymers,
Год журнала:
2022,
Номер
14(22), С. 4947 - 4947
Опубликована: Ноя. 16, 2022
The
aim
of
this
study
was
to
develop
a
novel
ultrathin
fibrous
membrane
with
core-sheath
structure
as
an
antioxidant
food
packaging
membrane.
prepared
by
coaxial
electrospinning,
and
the
release
active
substances
regulated
its
special
structure.
Ferulic
acid
(FA)
incorporated
into
electrospun
zein/polyethylene
oxide
fibers
ensure
their
synergistic
properties.
We
found
that
had
good
morphology
smooth
surface.
internal
stable,
three
materials
we
used
were
compatible.
For
different
loading
positions,
it
observed
core
layer
ferulic-acid-loaded
sustained
action,
while
sheath
pre-burst
action.
Finally,
apples
selected
for
using
membranes
simulate
practical
applications.
effective
in
reducing
water
loss
apple
quality
loss,
well
extending
shelf
life.
According
these
experiments,
FA-loaded
zein/PEO
electrospinning
fiber
can
be
will
also
undergo
more
improvements
future.
Polymers,
Год журнала:
2023,
Номер
15(4), С. 921 - 921
Опубликована: Фев. 12, 2023
Electrospun
porous
nanofibers
have
gained
a
lot
of
interest
recently
in
various
fields
because
their
adjustable
structure,
high
specific
surface
area,
and
large
number
active
sites,
which
can
further
enhance
the
performance
materials.
This
paper
provides
an
overview
common
polymers,
preparation,
applications
electrospun
nanofibers.
Firstly,
polymers
commonly
used
to
construct
structures
main
pore-forming
methods
by
electrospinning,
namely
template
method
phase
separation
method,
are
introduced.
Secondly,
recent
air
purification,
water
treatment,
energy
storage,
biomedicine,
food
packaging,
sensor,
sound
wave
absorption,
flame
retardant,
heat
insulation
reviewed.
Finally,
challenges
possible
research
directions
for
future
study
discussed.
Sustained
release
is
highly
desired
for
"efficacious,
safe
and
convenient"
drug
delivery,
particularly
those
anticancer
molecules
with
toxicity.
In
this
study,
a
modified
coaxial
electrospraying
process
was
developed
to
coat
hydrophobic
lipid,
i.e.,
stearic
acid
(SA),
on
composites
composed
of
the
tamoxifen
citrate
(TC)
insoluble
polymeric
matrix
ethylcellulose
(EC).
Compared
electrosprayed
TC-EC
composite
microparticles
M1,
SA-coated
hybrid
M2
were
able
provide
an
improved
TC
sustained-release
profile.
The
30%
90%
loaded
time
periods
extended
3.21
h
19.43
M2,
respectively,
which
significantly
longer
than
provided
by
M1
(0.88
9.98
h,
respectively).
morphology,
inner
structure,
physical
state,
compatibility
components
particles
disclosed
through
SEM,
TEM,
XRD,
FTIR.
Based
analyses,
mechanism
multiple
factors
co-acting
suggested,
include
reasonable
selections
organizations
lipid
excipient,
blank
SA
shell
loading,
regularly
round
shape,
also
high
density.
reported
protocols
pioneered
brand-new
manner
developing
sustained
delivery
hybrids
combination
cellulose
gels
using
electrospraying.
Macromolecular Materials and Engineering,
Год журнала:
2023,
Номер
309(4)
Опубликована: Ноя. 23, 2023
Abstract
In
this
study,
three
kinds
of
electrohydrodynamic
atomization
(EHDA)
processes
(electrospraying,
electrospinning,
and
coaxial
electrospinning)
are
implemented
to
create
hydroxypropyl
methylcellulose
(HPMC)
based
ultra‐thin
products
for
providing
the
fast
dissolution
a
poorly
water‐soluble
drug
ketoprofen
(KET).
An
EHDA
apparatus,
characterized
by
novel
spinneret,
is
homemade
conducting
processes.
The
types
electrospun
nanofibers
E1,
electrosprayed
microparticles
E2,
core‐shell
E3.
SEM
TEM
results
indicate
that
they
have
anticipated
morphologies
inner
structures.
X‐ray
diffraction
Fourier
Transform
Infrared
verify
KET
mainly
amorphous
in
all
composites
due
its
fine
compatibility
with
HPMC.
vitro
tests
demonstrate
rapid
release
performances
has
an
order
E3>E1>E2≫KET
powders.
mechanisms
suggested
advantages
compared.
super
performance
E3
furnishing
attributed
synergistic
action
small
size
(of
shell
thickness),
high
porosity,
state
drug,
solubility
nanostructures
can
support
development
nano
delivery
systems
(DDSs)
through
tailoring
spatial
distribution
molecules
within
products.
Biomolecules,
Год журнала:
2023,
Номер
13(1), С. 184 - 184
Опубликована: Янв. 16, 2023
Herbal
medicine
has
a
long
history
of
medical
efficacy
with
low
toxicity,
side
effects
and
good
biocompatibility.
However,
the
bioavailability
extract
raw
herbs
bioactive
compounds
is
poor
because
their
water
solubility.
In
order
to
overcome
solubility
issues,
electrospinning
technology
can
offer
delivery
alternative
resolve
them.
The
electrospun
fibers
have
advantages
high
specific
surface
area,
porosity,
excellent
mechanical
strength
flexible
structures.
At
same
time,
various
natural
synthetic
polymer-bound
mimic
extracellular
matrix
applications
in
different
fields.
this
paper,
development
polymers
used
for
incorporating
herbal
into
nanofibers
are
reviewed.
Finally,
recent
progress
these
biomedical
(drug
delivery,
wound
dressing,
tissue
engineering)
food
fields
along
future
prospects
discussed.
Pharmaceutics,
Год журнала:
2023,
Номер
15(11), С. 2561 - 2561
Опубликована: Окт. 31, 2023
Polymers
are
the
backbone
of
drug
delivery.
Electrospinning
has
greatly
enriched
strategies
that
have
been
explored
for
developing
novel
delivery
systems
using
polymers
during
past
two
decades.
In
this
study,
four
different
kinds
polymers,
i.e.,
water-soluble
polymer
poly
(vinyl
alcohol)
(PVA),
insoluble
poly(ε-caprolactone)
(PCL),
Eudragit
RL100
(ERL100)
and
pH-sensitive
S100
(ES100)
were
successfully
converted
into
types
tri-layer
tri-polymer
core-shell
fibers
through
bi-fluid
coaxial
electrospinning.
During
process,
model
metronidazole
(MTD)
was
loaded
shell
working
fluid,
which
an
emulsion.
The
micro-formation
mechanism
from
emulsion
electrospinning
proposed.
Scanning
electron
microscope
transmission
evaluations
verified
linear
morphology
resultant
their
obvious
multiple-chamber
structures.
X-ray
diffraction
Fourier
transform
infrared
spectroscopy
measurements
demonstrated
MTD
presented
in
amorphous
state
compatible
with
three
polymeric
matrices.
vitro
dissolution
tests
could
act
a
synergistic
manner
prolonged
sustained-release
profile
gut.
controlled-release
mechanisms
suggested
detail.
protocols
reported
here
pioneer
new
route
creating
structure
both
aqueous
organic
solvents,
strategy
advanced
sophisticated
profiles.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate
is
a
natural
polymer
with
good
biocompatible
properties
and
potential
polymeric
material
for
the
sustainable
development
replacement
of
petroleum
derivatives.
However,
non-spinnability
pure
alginate
solutions
has
hindered
expansion
applications.
With
continuous
electrospinning
technology,
synthetic
polymers,
such
as
PEO
PVA,
are
used
co-spinning
agents
to
increase
spinnability
alginate.
Moreover,
coaxial,
parallel
Janus,
tertiary
other
diverse
novel
electrospun
fiber
structures
prepared
by
multi-fluid
have
found
new
breakthrough
problem
poor
spinning
polymers.
Meanwhile,
effectively
achieve
multiple
release
modes
drugs.
The
powerful
combination
electrostatic
widely
in
many
biomedical
fields,
tissue
engineering,
regenerative
bioscaffolds,
drug
delivery,
research
fever
continues
climb.
This
particularly
true
controlled
delivery
aspect
review
provides
brief
overview
alginate,
introduces
advances
spinning,
highlights
progress
alginate-based
nanofibers
achieving
various
modes,
pulsed
release,
sustained
biphasic
responsive
targeted
release.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 15, 2023
Bacterial
prostatitis
is
a
challenging
condition
to
treat
with
traditional
dosage
forms.
Physicians
often
prescribe
variety
of
forms
different
administration
methods,
which
fail
provide
an
efficient
and
convenient
mode
drug
delivery.
The
aim
this
work
was
develop
new
type
hybrid
material
incorporating
both
electrosprayed
core-shell
microparticles
electrospun
nanofibers.
A
Chinese
medicine
(Ningmitai,
NMT)
Western
(ciprofloxacin,
CIP)
were
co-encapsulated
within
designed
be
released
in
separately
controlled
manner.
Utilizing
polyvinylpyrrolidone
(PVP)
as
hydrophilic
filament-forming
polymer
pH-sensitive
Eudragit
®
S100
(ES100)
the
particulate
polymeric
matrix,
combined
electrohydrodynamic
atomization
(EHDA)
method
comprising
coaxial
electrospraying
blending
electrospinning,
used
create
hybrids
single-step
straightforward
series
characterization
methods
conducted
analyze
working
process
its
final
products.
Scanning
electron
microscopy
transmission
revealed
that
EHDA
comprised
CIP-PVP
nanofibers
NMT-ES100
microparticles.
Multiple
confirmed
rapid
release
CIP
sustained
NMT.
antibacterial
experiments
indicated
exhibited
more
potent
effect
against
Escherichia
coli
dh5α
Bacillus
subtilis
Wb800
than
either
separate
or
amalgamation
fibrous
nanomedicine
micromedicine
can
expand
horizon
types
medicines.
integration
electrospinning
provides
approach
fabrication.
By
combining
soluble
polymers
hybrids,
we
ensure
sequential
NMT
for
potential
synergistic
therapy
bacterial
prostatitis.