Macromolecular Bioscience,
Год журнала:
2022,
Номер
23(1)
Опубликована: Сен. 30, 2022
Abstract
The
conversion
of
liquid
resin
into
solid
structures
upon
exposure
to
light
a
specific
wavelength
is
known
as
photopolymerization.
In
recent
years,
photopolymerization‐based
3D
printing
has
gained
enormous
attention
for
constructing
complex
tissue‐specific
constructs.
Due
the
economic
and
environmental
benefits
biopolymers
employed,
photo‐curable
considered
an
alternative
method
replacing
damaged
tissues.
However,
lack
suitable
bio‐based
photopolymers,
their
characterization,
effective
crosslinking
strategies,
optimal
conditions
are
hindering
extensive
application
printed
materials
in
global
market.
This
review
highlights
present
status
various
synthesis,
optimization
parameters
biomedical
applications.
Moreover,
glimpse
photopolymerization
techniques
currently
employed
also
discussed.
Furthermore,
naturally
derived
nanomaterials
reinforced
polymerization
influence
on
printability
shape
fidelity
reviewed.
Finally,
ultimate
use
those
photopolymerized
hydrogel
scaffolds
tissue
engineering
Taken
together,
it
believed
that
great
future,
whereas
conventional
requires
considerable
sophistication,
this
can
provide
readers
with
comprehensive
approach
developing
light‐mediated
tissue‐engineering
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(3), С. 100812 - 100812
Опубликована: Апрель 27, 2023
Biopolymers
are
promising
environmentally
benign
materials
applicable
in
multifarious
applications.
They
especially
favorable
implantable
biomedical
devices
thanks
to
their
excellent
unique
properties,
including
bioactivity,
renewability,
bioresorbability,
biocompatibility,
biodegradability
and
hydrophilicity.
Additive
manufacturing
(AM)
is
a
flexible
intricate
technology,
which
widely
used
fabricate
biopolymer-based
customized
products
structures
for
advanced
healthcare
systems.
Three-dimensional
(3D)
printing
of
these
sustainable
applied
functional
clinical
settings
wound
dressing,
drug
delivery
systems,
medical
implants
tissue
engineering.
The
present
review
highlights
recent
advancements
different
types
biopolymers,
such
as
proteins
polysaccharides,
employed
develop
by
using
extrusion,
vat
polymerization,
laser
inkjet
3D
techniques
addition
normal
bioprinting
four-dimensional
(4D)
techniques.
This
also
incorporates
the
influence
nanoparticles
on
biological
mechanical
performances
3D-printed
scaffolds.
work
addresses
current
challenges
well
future
developments
friendly
polymeric
manufactured
through
AM
Ideally,
there
need
more
focused
research
adequate
blending
biodegradable
biopolymers
achieving
useful
results
targeted
areas.
We
envision
that
composites
have
potential
revolutionize
sector
near
future.
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100823 - 100823
Опубликована: Окт. 1, 2023
Wound
care
and
treatment
can
be
critical
from
a
clinical
standpoint.
While
different
strategies
for
the
management
of
skin
wounds
have
been
developed,
limitations
inherent
in
current
approaches
necessitate
development
more
effective
alternative
strategies.
Advances
tissue
engineering
resulted
novel
promising
accelerating
wound
healing.
The
use
various
biomaterials
capable
regeneration
damaged
is
engineering.
In
this
regard,
cerium
oxide
nanoparticles
(CeO
Advanced Materials,
Год журнала:
2023,
Номер
36(34)
Опубликована: Сен. 22, 2023
Additive
manufacturing
(AM),
which
is
based
on
the
principle
of
layer-by-layer
shaping
and
stacking
discrete
materials,
has
shown
significant
benefits
in
fabrication
complicated
implants
for
tissue
engineering
(TE).
However,
many
native
tissues
exhibit
anisotropic
heterogenous
constructs
with
diverse
components
functions.
Consequently,
replication
biomimetic
using
conventional
AM
processes
a
single
material
challenging.
Multimaterial
3D
4D
bioprinting
(with
time
as
fourth
dimension)
emerged
promising
solution
constructing
multifunctional
that
can
mimic
host
microenvironment
better
than
single-material
alternatives.
Notably,
4D-printed
multimaterial
architectures
provide
time-dependent
programmable
dynamic
promote
cell
activity
regeneration
response
to
external
stimuli.
This
paper
first
presents
typical
design
strategies
TE
applications.
Subsequently,
latest
are
discussed,
along
their
advantages
challenges.
In
particular,
potential
smart
highlighted.
Furthermore,
this
review
provides
insights
into
how
facilitate
realization
next-generation
Advanced Materials,
Год журнала:
2024,
Номер
36(34)
Опубликована: Июнь 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Апрель 20, 2024
Abstract
Addressing
large
bone
defects
remains
a
significant
challenge
owing
to
the
inherent
limitations
in
self‐healing
capabilities,
resulting
prolonged
recovery
and
suboptimal
regeneration.
Although
current
clinical
solutions
are
available,
they
have
notable
shortcomings,
necessitating
more
efficacious
approaches
Organoids
derived
from
stem
cells
show
great
potential
this
field;
however,
development
of
organoids
has
been
hindered
by
specific
demands,
including
need
for
robust
mechanical
support
provided
scaffolds
hybrid
extracellular
matrices
(ECM).
In
context,
bioprinting
technologies
emerged
as
powerful
means
replicating
complex
architecture
tissue.
The
research
focused
on
fabrication
highly
intricate
ECM
analog
using
novel
bioink
composed
gelatin
methacrylate/alginate
methacrylate/hydroxyapatite
(GelMA/AlgMA/HAP).
Bioprinted
facilitate
long‐term
cultivation
progressive
maturation
extensive
bioprinted
organoids,
foster
multicellular
differentiation,
offer
valuable
insights
into
initial
stages
formation.
intrinsic
self‐mineralizing
quality
closely
emulates
properties
natural
bone,
empowering
with
enhanced
repair
both
vitro
vivo
applications.
This
trailblazing
investigation
propels
field
tissue
engineering
holds
promise
its
translation
practical
Bioactive Materials,
Год журнала:
2023,
Номер
25, С. 122 - 159
Опубликована: Фев. 2, 2023
Osteochondral
(OC)
repair
is
an
extremely
challenging
topic
due
to
the
complex
biphasic
structure
and
poor
intrinsic
regenerative
capability
of
natural
osteochondral
tissue.
In
contrast
current
surgical
approaches
which
yield
only
short-term
relief
symptoms,
tissue
engineering
strategy
has
been
shown
more
promising
outcomes
in
treating
OC
defects
since
its
emergence
1990s.
particular,
use
multizonal
scaffolds
(MZSs)
that
mimic
gradient
transitions,
from
cartilage
surface
subchondral
bone
with
either
continuous
or
discontinuous
compositions,
structures,
properties
tissue,
gaining
momentum
recent
years.
Scrutinizing
latest
developments
field,
this
review
offers
a
comprehensive
summary
advances,
hurdles,
future
perspectives
repair,
particularly
MZSs
including
bilayered,
trilayered,
multilayered,
scaffolds,
by
bringing
together
onerous
demands
architecture
designs,
material
selections,
manufacturing
techniques
as
well
choices
growth
factors
cells,
each
possesses
unique
challenges
opportunities.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Янв. 7, 2024
Abstract
The
incidence
of
large
bone
and
articular
cartilage
defects
caused
by
traumatic
injury
is
increasing
worldwide;
the
tissue
regeneration
process
for
these
injuries
lengthy
due
to
limited
self‐healing
ability.
Endogenous
bioelectrical
phenomenon
has
been
well
recognized
play
an
important
role
in
homeostasis
regeneration.
Studies
have
reported
that
electrical
stimulation
(ES)
can
effectively
regulate
various
biological
processes
holds
promise
as
external
intervention
enhance
synthesis
extracellular
matrix,
thereby
accelerating
Hence,
electroactive
biomaterials
considered
a
biomimetic
approach
ensure
functional
recovery
integrating
physiological
signals,
including
electrical,
biochemical,
mechanical
signals.
This
review
will
discuss
endogenous
bioelectricity
tissue,
effects
ES
on
cellular
behaviors.
Then,
recent
advances
materials
their
applications
are
systematically
overviewed,
with
focus
advantages
disadvantages
repair
performances
modulation
cell
fate.
Finally,
significance
mimicking
electrophysiological
microenvironment
target
emphasized
future
development
challenges
strategies
proposed.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 26, 2024
Abstract
Tissue
regeneration
technology
has
been
rapidly
developed
and
widely
applied
in
tissue
engineering
repair.
Compared
with
traditional
approaches
like
surgical
treatment,
the
rising
gene
therapy
is
able
to
have
a
durable
effect
on
regeneration,
such
as
impaired
bone
articular
cartilage
repair
cancer-resected
Gene
can
also
facilitate
production
of
situ
therapeutic
factors,
thus
minimizing
diffusion
or
loss
complexes
enabling
spatiotemporally
controlled
release
products
for
regeneration.
Among
different
delivery
vectors
supportive
gene-activated
matrices,
advanced
gene/drug
nanocarriers
attract
exceptional
attraction
due
their
tunable
physiochemical
properties,
well
excellent
adaptive
performance
bone,
cartilage,
blood
vessel,
nerve
This
paper
reviews
recent
advances
nonviral-mediated
systems
an
emphasis
important
role
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Melt
electrowriting
(MEW)
is
an
emerging
3D
printing
technology
that
can
precisely
fabricate
micro‐nano
fibrous
scaffolds
and
has
significant
application
prospects
in
tissue
engineering.
This
paper
reviews
the
latest
progress
of
MEW
engineering
scaffold
fabrication,
including
its
working
principle,
key
design
factors,
various
processable
biomaterials.
The
enhancement
function
through
filler
addition,
post‐treatment
modification,
combining
with
other
manufacturing
technologies
are
discussed.
bone,
cartilage,
blood
vessel,
nerve,
periodontal
analyzed.
Finally,
challenges
faces,
such
as
material
limitations,
equipment
reliability,
process
complexity,
highlighted,
future
development
directions
to
promote
wide
biomedical
fields
proposed.
