Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(4)
Опубликована: Июль 1, 2024
Nanozymes
are
nanomaterials
with
intrinsic
enzyme-like
activity
selected
advantages
over
native
enzymes
such
as
simple
synthesis,
controllable
activity,
high
stability,
and
low
cost.
These
materials
have
been
explored
surrogates
to
natural
in
biosensing,
therapeutics,
environmental
protection,
many
other
fields.
Among
different
nanozymes
classes,
metal-
metal
oxide-based
the
most
widely
studied.
In
recent
years,
bi-
tri-metallic
emerged
often
showing
improved
nanozyme
some
of
which
even
possess
multifunctional
activity.
Taking
this
concept
further,
high-entropy
nanomaterials,
that
is,
complex
multicomponent
alloys
ceramics
like
oxides,
may
potentially
enhance
further.
However,
addition
various
elements
increase
catalytic
come
at
cost
increased
toxicity.
Since
compositions
currently
being
for
vivo
biomedical
applications,
cancer
toxicity
considerations
relation
application
biomedicine
vital
importance
translation.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Toxicology
Regulatory
Issues
Nanomedicine
Nanomaterials
Diagnostic
Tools
Nanodevices.
Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Апрель 14, 2024
Although
nanozymes
have
drawn
great
attention
over
the
past
decade,
activities
of
peroxidase-like,
oxidase-like,
and
catalase-like
are
often
pH
dependent
with
elusive
mechanism,
which
largely
restricts
their
application.
Therefore,
a
systematical
discussion
on
pH-related
catalytic
mechanisms
together
methods
to
overcome
this
limitation
is
in
need.
In
review,
various
exhibiting
pH-dependent
collected
root
causes
for
dependence
comprehensively
analyzed.
Subsequently,
regulatory
concepts
including
environment
reconstruction
direct
activity
improvement
break
restriction
summarized.
Moreover,
applications
pH-independent
sensing,
disease
therapy,
pollutant
degradation
overviewed.
Finally,
current
challenges
future
opportunities
development
suggested.
It
anticipated
that
review
will
promote
further
design
broaden
application
range
higher
efficiency.
ACS Nano,
Год журнала:
2024,
Номер
18(19), С. 12049 - 12095
Опубликована: Май 2, 2024
Cancer,
as
one
of
the
leading
causes
death
worldwide,
drives
advancement
cutting-edge
technologies
for
cancer
treatment.
Transition-metal-based
nanozymes
emerge
promising
therapeutic
nanodrugs
that
provide
a
reference
therapy.
In
this
review,
we
present
recent
breakthrough
First,
comprehensively
outline
preparation
strategies
involved
in
creating
transition-metal-based
nanozymes,
including
hydrothermal
method,
solvothermal
chemical
reduction
biomimetic
mineralization
and
sol–gel
method.
Subsequently,
elucidate
catalytic
mechanisms
(catalase
(CAT)-like
activities),
peroxidase
(POD)-like
oxidase
(OXD)-like
activities)
superoxide
dismutase
(SOD)-like
along
with
their
activity
regulation
such
morphology
control,
size
manipulation,
modulation,
composition
adjustment
surface
modification
under
environmental
stimulation.
Furthermore,
elaborate
on
diverse
applications
anticancer
therapies
encompassing
radiotherapy
(RT),
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
photothermal
(PTT),
sonodynamic
(SDT),
immunotherapy,
synergistic
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
The
purpose
review
is
to
offer
scientific
guidance
will
enhance
clinical
based
transition
metals.
Abstract
Nanozymes
have
emerged
as
a
promising
alternative
to
natural
enzymes,
effectively
addressing
enzymes'
inherent
limitation.
Versatility
and
potential
applications
of
nanozyme
span
across
various
fields,
with
catalytic
tumor
therapy
being
one
prominent
area.
This
has
sparked
significant
interest
exploration
in
the
utilization
nanozymes
for
targeted
cancer
treatment.
Recent
advancements
interdisciplinary
research,
nanotechnology,
biotechnology,
technology
led
emergence
multi‐metallic‐based
nanozymes,
which
exhibit
tremendous
further
development.
review
focuses
on
investigating
synergistic
effects
aiming
enhance
our
understanding
their
activities
facilitate
broader
applications.
We
comprehensively
survey
remarkable
achievements
synthesis,
mechanisms,
latest
therapy.
Furthermore,
we
identify
current
limitations
prospects
development
new
materials
application
novel
technologies,
along
challenges
associated
underscores
significance
emphasizes
need
continued
well
impact
realization
breakthroughs
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(1)
Опубликована: Сен. 24, 2023
Copper
(Cu),
an
indispensable
trace
element
within
the
human
body,
serving
as
intrinsic
constituent
of
numerous
natural
enzymes,
carrying
out
vital
biological
functions.
Furthermore,
nanomaterials
exhibiting
enzyme-mimicking
properties,
commonly
known
nanozymes,
possess
distinct
advantages
over
their
enzyme
counterparts,
including
cost-effectiveness,
enhanced
stability,
and
adjustable
performance.
These
advantageous
attributes
have
captivated
attention
researchers,
inspiring
them
to
devise
various
Cu-based
nanomaterials,
such
copper
oxide,
Cu
metal-organic
framework,
CuS,
explore
potential
in
enzymatic
catalysis.
This
comprehensive
review
encapsulates
most
recent
advancements
illuminating
applications
realm
biochemistry.
Initially,
it
is
delved
into
emulation
typical
types
achieved
by
nanomaterials.
Subsequently,
latest
breakthroughs
concerning
nanozymes
biochemical
sensing,
bacterial
inhibition,
cancer
therapy,
neurodegenerative
diseases
treatment
discussed.
Within
this
segment,
also
explored
modulation
nanozyme
activity.
Finally,
a
visionary
outlook
for
future
development
presented.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(26)
Опубликована: Май 18, 2023
Photodynamic
therapy
(PDT),
as
a
light
irradiation
inducing
reactive
oxygen
species
(ROS)
generation
for
cancer
treatment,
offers
facile
and
promising
solutions
with
respect
to
spatiotemporal
control
of
ROS
generation,
minimizes
the
systemic
toxicity
side
effects
highly
precise
tumor
therapy.
However,
PDT
efficiency
is
often
severely
compromised
by
complex
microenvironment
(TME),
such
hypoxic
condition
overexpressed
antioxidants.
Here,
first
time,
bimetallic
ion-modified
metal-organic
framework
nanozyme
(Zr4+
-MOF-Ru3+
/Pt4+
-Ce6@HA,
ZMRPC@HA)
designed.
ZMRPC@HA
catalase
(CAT)
glutathione
oxidase
(GSHOx)
mimetic
activities,
can
efficiently
regulate
TME
O2
deplete
GSH
synergistically
enhancing
long-term
efficacy
toward
tumor.
The
in
vitro
cell
inhibition
vivo
on
xenograft
evaluations
demonstrate
strategy
using
successfully
inhibit
differentiation
proliferation
cells
under
660
nm
laser
deep
tissues.
These
findings
open
new
avenue
design
multimetallic
ions
functionalized
MOF-based
nanozymes
multienzyme
activities
antitumor
various
other
biological
applications.
ACS Nano,
Год журнала:
2023,
Номер
17(21), С. 21553 - 21566
Опубликована: Ноя. 1, 2023
Designing
mitochondria-targeting
phototheranostic
agents
(PTAs),
which
can
simultaneously
possess
exceptional
and
balanced
type-I
photodynamic
therapy
(PDT)
photothermal
(PTT)
performance,
still
remains
challenging.
Herein,
benzene,
furan,
thiophene
were
utilized
as
π
bridges
to
develop
multifunctional
PTAs.
STB
with
a
bridge,
in
particular,
benefiting
from
stronger
donor–accepter
(D–A)
interactions,
reduced
the
singlet–triplet
energy
gap
(ΔES1-T1),
allowed
more
free
intramolecular
rotation,
exhibited
outstanding
near-infrared
(NIR)
emission,
effective
reactive
oxygen
species
(ROS)
generation,
relatively
high
conversion
efficiency
(PCE)
of
51.9%.
In
vitro
vivo
experiments
demonstrated
that
positive-charged
not
only
actively
target
mitochondria
tumor
cells
but
also
displayed
strong
antitumor
effects
excellent
imaging
ability.
This
work
subtly
established
win–win
strategy
by
bridge
engineering,
breaking
barrier
making
balance
between
ROS
generation
conversion,
boosting
dual
enhancement
PDT
PTT
stimulating
development
multimodal
imaging-guided
precise
cancer
phototherapy.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(2)
Опубликована: Сен. 29, 2023
Abstract
In
reactive‐oxygen‐species‐mediated
tumor
therapy,
the
generation
and
accumulation
of
·OH
is
highly
dependent
on
peroxidase
(POD)‐like
enzymatic
activities
antioxidant
microenvironment.
As
noble
metal
nanoalloys
can
enhance
POD‐like
activity
by
improving
electron
transfer
upgrading
active
sites,
PdCu
x
(
=
0.6–1.2)
bimetallic
with
optimized
activity,
enhanced
photothermal
conversion
efficiency,
altered
glutathione
(GSH)
consumption
ability
are
synthesized
a
facile
co‐reduction
method.
The
between
Pd
Cu
in
their
new
+
catalytic
centers
contribute
to
“hand‐in‐hand”
collaboration
activities,
while
properties
remain
almost
unchanged
because
“back‐to‐back”
confrontation
occurring
owing
excess
produced
surface
plasmon
resonance
effect.
Moreover,
intrinsic
GSH
those
heat
from
effect
tilt
redox
steady
state.
Therefore,
0.9
nanoalloy
show
excellent
resulting
route,
which
involves
electron‐enriched
hydrogen
peroxide
heat‐enhanced
/Cu
2+
‐coupled
Fenton‐like
reactions.
shed
light
mechanism
responsible
for
enhancing
offer
typical
model
constructing
next‐generation
alloy
nanozymes.
