Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: April 14, 2024

Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.

Language: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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Recent advances in multi‐metallic‐based nanozymes for enhanced catalytic cancer therapy

BMEMat, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 19, 2023

Abstract Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest exploration in the utilization nanozymes for targeted cancer treatment. Recent advancements interdisciplinary research, nanotechnology, biotechnology, technology led emergence multi‐metallic‐based nanozymes, which exhibit tremendous further development. review focuses on investigating synergistic effects aiming enhance our understanding their activities facilitate broader applications. We comprehensively survey remarkable achievements synthesis, mechanisms, latest therapy. Furthermore, we identify current limitations prospects development new materials application novel technologies, along challenges associated underscores significance emphasizes need continued well impact realization breakthroughs

Language: Английский

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Recent Development of Copper‐Based Nanozymes for Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 24, 2023

Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.

Language: Английский

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Recent advances in metal-based nanomaterials for malignant bone tumor therapy

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 288, P. 117427 - 117427

Published: Feb. 20, 2025

Language: Английский

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Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 5, 2025

The efficacy of current therapies for ovarian cancer is limited due to the multilevel and complex tumor microenvironment (TME), which induces drug resistance progression in a single treatment regimen. Additionally, poor targeting insufficient tissue penetration are important constraints treatment. We constructed PH20-overexpressing cancer-associated fibroblast (CAF)-cancer hybrid-cell membrane vesicles (PH20/CCM) dual-targeted delivery carboplatin (CBP) siRNA p65 (sip65) loaded on poly (dimethyl diallyl ammonium chloride) (PDDA)-modified MXene (PMXene), named PMXene@CBP-sip65 (PMCS). nanoparticle PH20/CCM@PMCS could penetrate extracellular matrix tissues target both cells CAFs. After cell internalization, these nanoparticles significantly inhibited proliferation, generated reactive oxygen species, induced endoplasmic reticulum stress, triggered immunogenic death. CAF they pro-tumor factor release activated immune effects, promoting system infiltration. In an experiment with ID8 homograft-carrying mice, improved inhibition enhanced infiltration tissues. These new therapeutic can simultaneously cells, CAFs, matrix, thereby increasing sensitivity improving TME. Therefore, TME-regulating nanoparticles, combining specificity, efficiency, effectiveness, provide insights into

Language: Английский

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Bimetallic Ions Functionalized Metal–Organic‐Framework Nanozyme for Tumor Microenvironment Regulating and Enhanced Photodynamic Therapy for Hypoxic Tumor

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(26)

Published: May 18, 2023

Photodynamic therapy (PDT), as a light irradiation inducing reactive oxygen species (ROS) generation for cancer treatment, offers facile and promising solutions with respect to spatiotemporal control of ROS generation, minimizes the systemic toxicity side effects highly precise tumor therapy. However, PDT efficiency is often severely compromised by complex microenvironment (TME), such hypoxic condition overexpressed antioxidants. Here, first time, bimetallic ion-modified metal-organic framework nanozyme (Zr4+ -MOF-Ru3+ /Pt4+ -Ce6@HA, ZMRPC@HA) designed. ZMRPC@HA catalase (CAT) glutathione oxidase (GSHOx) mimetic activities, can efficiently regulate TME O2 deplete GSH synergistically enhancing long-term efficacy toward tumor. The in vitro cell inhibition vivo on xenograft evaluations demonstrate strategy using successfully inhibit differentiation proliferation cells under 660 nm laser deep tissues. These findings open new avenue design multimetallic ions functionalized MOF-based nanozymes multienzyme activities antitumor various other biological applications.

Language: Английский

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PdCu_x Bimetallic Nanoalloys with “Hand‐in‐Hand” Collaboration in POD‐like Activity and “Back‐to‐Back” Confrontation in SPR Effect for Tumor Redox System Control

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(2)

Published: Sept. 29, 2023

Abstract In reactive‐oxygen‐species‐mediated tumor therapy, the generation and accumulation of ·OH is highly dependent on peroxidase (POD)‐like enzymatic activities antioxidant microenvironment. As noble metal nanoalloys can enhance POD‐like activity by improving electron transfer upgrading active sites, PdCu x ( = 0.6–1.2) bimetallic with optimized activity, enhanced photothermal conversion efficiency, altered glutathione (GSH) consumption ability are synthesized a facile co‐reduction method. The between Pd Cu in their new + catalytic centers contribute to “hand‐in‐hand” collaboration activities, while properties remain almost unchanged because “back‐to‐back” confrontation occurring owing excess produced surface plasmon resonance effect. Moreover, intrinsic GSH those heat from effect tilt redox steady state. Therefore, 0.9 nanoalloy show excellent resulting route, which involves electron‐enriched hydrogen peroxide heat‐enhanced /Cu 2+ ‐coupled Fenton‐like reactions. shed light mechanism responsible for enhancing offer typical model constructing next‐generation alloy nanozymes.

Language: Английский

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π Bridge Engineering-Boosted Dual Enhancement of Type-I Photodynamic and Photothermal Performance for Mitochondria-Targeting Multimodal Phototheranostics of Tumor

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 21553 - 21566

Published: Nov. 1, 2023

Designing mitochondria-targeting phototheranostic agents (PTAs), which can simultaneously possess exceptional and balanced type-I photodynamic therapy (PDT) photothermal (PTT) performance, still remains challenging. Herein, benzene, furan, thiophene were utilized as π bridges to develop multifunctional PTAs. STB with a bridge, in particular, benefiting from stronger donor–accepter (D–A) interactions, reduced the singlet–triplet energy gap (ΔES1-T1), allowed more free intramolecular rotation, exhibited outstanding near-infrared (NIR) emission, effective reactive oxygen species (ROS) generation, relatively high conversion efficiency (PCE) of 51.9%. In vitro vivo experiments demonstrated that positive-charged not only actively target mitochondria tumor cells but also displayed strong antitumor effects excellent imaging ability. This work subtly established win–win strategy by bridge engineering, breaking barrier making balance between ROS generation conversion, boosting dual enhancement PDT PTT stimulating development multimodal imaging-guided precise cancer phototherapy.

Language: Английский

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Ag-MXene as peroxidase-mimicking nanozyme for enhanced bacteriocide and cholesterol sensing

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 653, P. 540 - 550

Published: Sept. 17, 2023

Language: Английский

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