Nanoscale Horizons,
Год журнала:
2023,
Номер
8(10), С. 1333 - 1344
Опубликована: Янв. 1, 2023
Recently,
great
progress
has
been
made
in
nanozyme
research
due
to
the
rapid
development
of
nanomaterials
and
nanotechnology.
MXene-based
have
gained
considerable
attention
owing
their
unique
physicochemical
properties.
They
found
high
enzyme-like
properties,
such
as
peroxidase,
oxidase,
catalase,
superoxide
dismutase.
In
this
mini-review,
we
present
an
overview
recent
nanozymes,
with
emphasis
on
synthetic
methods,
hybridization,
bio-catalytic
biomedical
applications.
The
future
challenges
prospects
nanozymes
are
also
proposed.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4139 - 4139
Опубликована: Апрель 9, 2024
Bone
tumors,
particularly
osteosarcoma,
are
prevalent
among
children
and
adolescents.
This
ailment
has
emerged
as
the
second
most
frequent
cause
of
cancer-related
mortality
in
Conventional
treatment
methods
comprise
extensive
surgical
resection,
radiotherapy,
chemotherapy.
Consequently,
management
bone
tumors
regeneration
poses
significant
clinical
challenges.
Photothermal
tumor
therapy
attracted
considerable
attention
owing
to
its
minimal
invasiveness
high
selectivity.
However,
key
challenges
have
limited
widespread
use.
Enhancing
specificity
photosensitizers
through
targeting
or
localized
activation
holds
potential
for
better
outcomes
with
fewer
adverse
effects.
Combinations
chemotherapies
immunotherapies
also
present
avenues
improvement.
In
this
review,
we
provide
an
overview
recent
strategies
aimed
at
overcoming
limitations
photothermal
(PTT),
along
current
research
directions
context
including
(1)
target
strategies,
(2)
combined
multiple
therapies
(immunotherapies,
chemotherapies,
chemodynamic
therapies,
magnetic,
photodynamic
therapies),
(3)
bifunctional
scaffolds
regeneration.
We
delve
into
pros
cons
these
combination
explore
focal
points.
Lastly,
address
prospects
therapy.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
265, С. 130960 - 130960
Опубликована: Март 20, 2024
Tumors
remain
one
of
the
major
threats
to
public
health
and
there
is
an
urgent
need
design
new
pharmaceutical
agents
for
their
diagnosis
treatment.
In
recent
years,
due
rapid
development
nanotechnology,
biotechnology,
catalytic
science,
theoretical
computing,
subtlety
has
gradually
made
great
progress
in
research
related
tumor
Compared
conventional
drugs,
enzymes
can
improve
drug
distribution
enhance
enrichment
at
site,
thereby
reducing
side
effects
enhancing
efficacy.
Nanozymes
also
be
used
as
tracking
imaging
reshape
microenvironment,
providing
a
versatile
platform
treatment
malignancies.
this
paper,
we
review
current
status
on
oncology
analyze
novel
therapeutic
approaches
mechanisms.
To
date,
large
number
nanomaterials,
such
noble
metal
nonmetallic
carbon-based
have
been
shown
able
function
like
natural
enzymes,
particularly
with
significant
advantages
therapy.
light
this,
authors
systematically
summarized
evaluated
construction,
enzymatic
activity,
characteristics
nanozymes
respect
modalities
addition,
application
different
types
nicknames
features
years
are
detail.
We
conclude
summary
outlook
study
It
hoped
that
will
inspire
researchers
fields
chemistry,
biology,
materials
science
contribute
nano-enzymology.
Nanoscale,
Год журнала:
2024,
Номер
16(16), С. 7786 - 7824
Опубликована: Янв. 1, 2024
The
therapeutic
efficacy
of
nanozymes,
which
have
wide
applications
in
cancer
treatment,
can
be
enhanced
by
various
biomimetic
design
strategies,
from
structural
and
process
mimicry
to
advanced
functional
biomimicry.
Different
from
the
direct
delivery
of
chemodynamic
agents
into
tumor
tissue
for
therapy
(CDT),
this
work
reports
fabrication
heterojunction
sonosensitizers
(CD/TiSe
2
)
in
situ
generation
by
responding
to
microenvironment
(TME),
realizing
CDT‐enhanced
sono‐immunotherapy.
The
redox
TiSe
acidic
TME
leads
formation
TiO
x
Se
2−
containing
(0),
selenate,
and
Ti
3+
/Ti
4+
couple,
which
can
facilitate
CDT
through
a
‐mediated
Fenton‐like
reaction
consume
overexpressed
glutathione
(GSH)
via
GSH
depletion.
Moreover,
ions
generated
process
promote
maturation
dendritic
cells,
consequently
activating
adaptive
immune
responses.
In
another
aspect,
construction
heterojunctions
within
carbon
dots
improves
reactive
oxygen
species
(ROS)
efficiency
cascaded
manner,
enhances
sonodynamic
activity
amplifies
performance.
More
importantly,
ROS
produced
efficiently
triggers
immunogenic
cell
death
synergistic
based
on
elicitation
antitumor
immunity
with
aid
an
checkpoint
blockade.
This
thus
provides
distinct
paradigm
transition
metal
selenide‐originated
agent
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(18), С. 9059 - 9132
Опубликована: Янв. 1, 2024
Nanodrugs,
which
utilise
nanomaterials
in
disease
prevention
and
therapy,
have
attracted
considerable
interest
since
their
initial
conceptualisation
the
1990s.
Substantial
efforts
been
made
to
develop
nanodrugs
for
overcoming
limitations
of
conventional
drugs,
such
as
low
targeting
efficacy,
high
dosage
toxicity,
potential
drug
resistance.
Despite
significant
progress
that
has
nanodrug
discovery,
precise
design
or
screening
with
desired
biomedical
functions
prior
experimentation
remains
a
challenge.
This
is
particularly
case
regard
personalised
precision
nanodrugs,
require
simultaneous
optimisation
structures,
compositions,
surface
functionalities
nanodrugs.
The
development
powerful
computer
clusters
algorithms
it
possible
overcome
this
challenge
through
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 5, 2025
The
efficacy
of
current
therapies
for
ovarian
cancer
is
limited
due
to
the
multilevel
and
complex
tumor
microenvironment
(TME),
which
induces
drug
resistance
progression
in
a
single
treatment
regimen.
Additionally,
poor
targeting
insufficient
tissue
penetration
are
important
constraints
treatment.
We
constructed
PH20-overexpressing
cancer-associated
fibroblast
(CAF)-cancer
hybrid-cell
membrane
vesicles
(PH20/CCM)
dual-targeted
delivery
carboplatin
(CBP)
siRNA
p65
(sip65)
loaded
on
poly
(dimethyl
diallyl
ammonium
chloride)
(PDDA)-modified
MXene
(PMXene),
named
PMXene@CBP-sip65
(PMCS).
nanoparticle
PH20/CCM@PMCS
could
penetrate
extracellular
matrix
tissues
target
both
cells
CAFs.
After
cell
internalization,
these
nanoparticles
significantly
inhibited
proliferation,
generated
reactive
oxygen
species,
induced
endoplasmic
reticulum
stress,
triggered
immunogenic
death.
CAF
they
pro-tumor
factor
release
activated
immune
effects,
promoting
system
infiltration.
In
an
experiment
with
ID8
homograft-carrying
mice,
improved
inhibition
enhanced
infiltration
tissues.
These
new
therapeutic
can
simultaneously
cells,
CAFs,
matrix,
thereby
increasing
sensitivity
improving
TME.
Therefore,
TME-regulating
nanoparticles,
combining
specificity,
efficiency,
effectiveness,
provide
insights
into
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 11, 2025
The
application
of
photodynamic
therapy
(PDT)
is
limited
by
unsatisfactory
therapeutic
efficacy
and
dose-dependent
phototoxicity
in
clinical
settings.
Intravenous
nano-drug
delivery
systems
(NDDSs)
hold
promise
for
enhancing
the
efficiency
photosensitive
drugs,
but
often
result
aggregation-caused
quenching
(ACQ)
effects,
preventing
site-specific
activation.
We
exploited
manganese
(Mn2+)-pyrochloric
acid
(PPa)
nanocomplexes
coordinated
using
photosensitizer
PPa
metal
Mn
ion
treatment
osteosarcoma.
were
precisely
co-assembled
water
to
stably
co-deliver
Mn2+
PPa,
enabling
tumor-specific
release
fluorescence
recovery.
Following
laser
irradiation,
activated
significantly
enhanced
killing
effects
on
primary
cancer
cells.
Additionally,
ions
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway,
promoting
maturation
dendritic
cells
(DCs)
augmenting
CD8+-mediated
antitumor
immune
responses.
This
study
advances
on-demand
activation
drugs
immunotherapy
toward
applicability
exploiting
Mn2+-PPa
with
high
activatability
effectiveness
targeted
PDT
immunotherapy.
Nano Letters,
Год журнала:
2023,
Номер
24(1), С. 295 - 304
Опубликована: Дек. 20, 2023
Chemodynamic
therapy
based
on
the
Fenton
reaction
has
been
developed
as
an
extremely
promising
modality
for
cancer
therapeutics.
In
this
study,
a
core–shell
structure
nanoplatform
was
constructed
by
Au
nanorod
externally
encapsulating
Ce/Zn-based
composites
(ACZO).
The
nanoparticles
can
catalyze
generation
of
reactive
oxygen
species
(ROS)
under
acidic
conditions
and
effectively
consume
existing
glutathione
(GSH)
to
destroy
redox
balance
within
tumor.
Moreover,
decomposition
nanocomplexes
releases
large
amounts
zinc
ions,
leading
overload
in
cells.
photothermal
effect
generated
nanorods
not
only
provides
(PTT)
but
also
augments
catalytic
ions
action
mentioned
above.
This
facile
strategy
improve
efficacy
chemodynamic
enhancement
activity
ion
release
perspective
potential
tumor
treatment.
