Copper‐Based Composites Nanoparticles Improve Triple‐Negative Breast Cancer Treatment with Induction of Apoptosis‐Cuproptosis and Immune Activation
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(28)
Опубликована: Июль 12, 2024
The
synergistic
effect
of
apoptosis
and
cuproptosis,
along
with
the
activation
immune
system,
presents
a
promising
approach
to
enhance
efficacy
against
triple-negative
breast
cancer
(TNBC).
Here,
two
prodrugs
are
synthesized:
reactive
oxygen
species
(ROS)-responsive
prodrug
PEG-TK-DOX
glutathione
(GSH)-responsive
PEG-DTPA-SS-CPT.
These
self-assembled
chelated
Cu2+
prepare
nanoparticle
PCD@Cu
that
simultaneously
loaded
doxorubicin
(DOX),
camptothecin
(CPT),
Cu2+.
elevated
levels
ROS
GSH
in
TNBC
cells
disrupted
structure,
leading
release
Cu+,
DOX,
CPT
depletion
GSH.
DOX
triggered
immunogenic
cell
death
(ICD)
cells.
Simultaneously,
downregulated
expression
copper
transporting
ATPase
2
(ATP7B),
causing
significant
accumulation
ions
This
further
induced
aggregation
lipoylated
dihydrolipoamide
S-acetyltransferase
(DLAT)
downregulation
iron-sulfur
(Fe-S)
cluster
proteins,
ultimately
cuproptosis
ICD
TNBC.
In
vitro
vivo
experiments
confirmed
activated
demonstrating
strong
anti-tumor
capabilities.
Moreover,
exhibited
an
excellent
biosafety
profile.
Overall,
this
study
provides
strategy
for
effective
therapy.
Язык: Английский
Composite bioreactor for synergistic Modulation of tumor microenvironment and endogenous Regulation of ROS generation to enhance chemodynamic therapy for lung cancer
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
683, С. 918 - 929
Опубликована: Янв. 4, 2025
Язык: Английский
Carbon dot decorated covalent organic framework for mild NIR-II photothermal and heterojunction amplified sonodynamic and chemodynamic therapy
Carbon,
Год журнала:
2025,
Номер
unknown, С. 119987 - 119987
Опубликована: Янв. 1, 2025
Язык: Английский
Defect Engineering of Biodegradable Sulfide Nanocage Sonozyme Systems Enables Robust Immunotherapy Against Metastatic Cancers
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 9, 2024
Abstract
It
is
important
but
challenging
to
innovate
inorganic
sonosensitizers
with
controlled
biodegradability
and
enhanced
sonodynamic
chemodynamic
activities
harness
remodel
the
immunosuppressive
tumor
microenvironment
(TME)
for
awakening
robust
immune
responses
against
metastatic
cancers.
Herein
rational
design
defect
engineering
strategy
of
a
pH‐responsive
biodegradable
sonozyme
system
in
sulfide
nanocages
augmented
cancer
immunotherapy
reported.
A
series
highly
defective
Co
9
S
8‐x
elevated
sulfur‐vacancy
(V
)
levels
are
fabricated
systematically
explore
V
‐dependent
properties
by
regulating
weight
ratio
sulfur
cobalt
source.
The
bandgap
substantially
reduced
from
2.06
1.54
eV,
atomic
2+
3+
increased
1.53
1.97.
Therefore,
sonodynamic,
chemodynamic,
antitumor
dramatically
system.
slow
degradation
slightly
acid
TME
size
targeting
infiltration,
while
exerting
slight
influence
on
performance.
As
result,
satisfactory
therapeutic
effects
eradication
primary,
distant,
tumors
can
be
achieved.
This
work
highlights
potential
strategies
combating
Язык: Английский
In situ construction of heterojunctions to regulate the biodegradation behavior of copper carriers for tumor-specific cuproptosis-enhanced sono-immunotherapy
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 25, 2025
Cuproptosis,
a
novel
approach
utilizing
copper
carriers
to
trigger
programmed
cell
death,
exhibits
promise
for
enhancing
traditional
therapies
and
activating
robust
adaptive
immune
responses.
However,
the
uncontrolled
release
of
Cu
ions
risks
triggering
cuproptosis
in
healthy
tissues,
potentially
causing
irreversible
damage.
To
address
this,
we
report
on
use
Cu-MOF
(copper
metal-organic
framework)
protective
layer
regulate
biodegradation
copper-based
nanomaterials.
In
situ
formation
Cu2O
nanocubes
not
only
stabilizes
material
under
physiological
conditions
but
also
enhances
its
sonodynamic
therapy
(SDT)
capabilities
by
establishing
Z-Scheme
heterojunction.
Upon
SDT
activation,
targeted
ion
at
tumor
site
triggers
cascade
reactions,
generating
reactive
oxygen
species
(ROS)
via
Fenton-like
processes
depleting
glutathione
(GSH).
This
ROS
surge,
combined
with
effective
cuproptosis,
modulates
immunosuppressive
microenvironment,
inducing
immunogenic
death
eliminate
primary
tumors
inhibit
metastasis.
study
offers
new
paradigm
controlled
integration
SDT,
chemodynamic
(CDT),
immunotherapy,
achieving
precise
tumor-targeted
treatment
nanomaterial
degradation.
Язык: Английский
Tumor Microenvironment Activated Cu Crosslinked Near‐Infrared Sonosensitizers for Visualized Cuproptosis‐Enhanced Sonodynamic Cancer Immunotherapy
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 27, 2024
Abstract
Reactive
oxygen
species
(ROS)‐mediated
sonodynamic
therapy
(SDT)
holds
increasing
potential
in
treating
deep‐seated
tumor
owing
to
the
high
tissue‐penetration
depth.
However,
inevitable
accumulation
of
sonosensitizers
normal
tissues
not
only
make
it
difficult
realize
situ
SDT,
but
also
induces
effects
tissues.
Herein,
this
work
reports
passivation
and
selective
activation
strategies
for
near‐infrared
(NIR)
imaging
performances
an
intelligent
antitumor
theranostic
platform
termed
Cu‐IR783
nanoparticles
(NPs).
Owing
ruptured
coordination
bond
between
IR783
with
Cu
ions
by
responding
microenvironment
(TME),
occurred
achieve
visualized
in‐situ
SDT.
The
tumor‐specific
released
realized
cascade
amplification
ROS
generation
through
+
‐mediated
Fenton‐like
reaction,
triggered
cuproptosis
‐induced
DLAT
oligomerization
mitochondrial
dysfunction.
More
importantly,
immunosuppressive
TME
can
be
reversed
greatly
enhanced
levels
high‐efficiency
cuproptosis,
ultimately
inducing
immunogenic
cell
death
that
promotes
robust
systemic
immune
responses
eradication
primary
tumors
suppression
distant
tumors.
This
provides
a
distinct
paradigm
integration
CDT,
controlled
manner
therapy.
Язык: Английский
Tumor microenvironment activated MXene-protected Cu2O heterojunctions induce tumor-specific cuproptosis for enhanced sono-immunotherapy
Chemical Engineering Journal,
Год журнала:
2024,
Номер
unknown, С. 156753 - 156753
Опубликована: Окт. 1, 2024
Язык: Английский
Progress in application of nanomedicines for enhancing cancer sono-immunotherapy
Hongxin Zhao,
Fangxue Du,
Xiang Xi
и другие.
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
111, С. 107105 - 107105
Опубликована: Окт. 15, 2024
Язык: Английский
Graphene Quantum Dot Sensitized Heterojunctions Induce Tumor‐Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced Cancer Immunotherapy
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Cuproptosis
that
utilizes
copper
ionophore
to
induce
programmed
cell
death
holds
promise
for
enhancing
the
effectiveness
of
conventional
anticancer
therapies
and
triggering
efficient
adaptive
immune
responses.
However,
non-tumor-specific
release
Cu
ions
can
cuproptosis
cause
irreversible
damage
normal
tissues.
To
maximize
therapeutic
effects
tumor-specific
cuproptosis,
this
work
reports
first
time
regulation
degradation
behaviors
Cu-based
nanomaterials
using
graphene
quantum
dots
(GQDs)
as
a
protection
layer.
The
deposition
GQDs
not
only
avoids
Язык: Английский