Nanozymes for biomedical applications: Multi‐metallic systems may improve activity but at the cost of higher toxicity? DOI Creative Commons
Thüong Phan‐Xuan, Ben Breitung, Lea Ann Dailey

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(4)

Published: July 1, 2024

Nanozymes are nanomaterials with intrinsic enzyme-like activity selected advantages over native enzymes such as simple synthesis, controllable activity, high stability, and low cost. These materials have been explored surrogates to natural in biosensing, therapeutics, environmental protection, many other fields. Among different nanozymes classes, metal- metal oxide-based the most widely studied. In recent years, bi- tri-metallic emerged often showing improved nanozyme some of which even possess multifunctional activity. Taking this concept further, high-entropy nanomaterials, that is, complex multicomponent alloys ceramics like oxides, may potentially enhance further. However, addition various elements increase catalytic come at cost increased toxicity. Since compositions currently being for vivo biomedical applications, cancer toxicity considerations relation application biomedicine vital importance translation. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Toxicology Regulatory Issues Nanomedicine Nanomaterials Diagnostic Tools Nanodevices.

Language: Английский

Advancements in Photothermal Therapy Using Near-Infrared Light for Bone Tumors DOI Open Access

Mengzhang Xie,

Taojun Gong, Yitian Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4139 - 4139

Published: April 9, 2024

Bone tumors, particularly osteosarcoma, are prevalent among children and adolescents. This ailment has emerged as the second most frequent cause of cancer-related mortality in Conventional treatment methods comprise extensive surgical resection, radiotherapy, chemotherapy. Consequently, management bone tumors regeneration poses significant clinical challenges. Photothermal tumor therapy attracted considerable attention owing to its minimal invasiveness high selectivity. However, key challenges have limited widespread use. Enhancing specificity photosensitizers through targeting or localized activation holds potential for better outcomes with fewer adverse effects. Combinations chemotherapies immunotherapies also present avenues improvement. In this review, we provide an overview recent strategies aimed at overcoming limitations photothermal (PTT), along current research directions context including (1) target strategies, (2) combined multiple therapies (immunotherapies, chemotherapies, chemodynamic therapies, magnetic, photodynamic therapies), (3) bifunctional scaffolds regeneration. We delve into pros cons these combination explore focal points. Lastly, address prospects therapy.

Language: Английский

Citations

15
Application and progress of nanozymes in antitumor therapy DOI Creative Commons

Gaihua He,

Chao Mei,

Chenbo Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130960 - 130960

Published: March 20, 2024

Tumors remain one of the major threats to public health and there is an urgent need design new pharmaceutical agents for their diagnosis treatment. In recent years, due rapid development nanotechnology, biotechnology, catalytic science, theoretical computing, subtlety has gradually made great progress in research related tumor Compared conventional drugs, enzymes can improve drug distribution enhance enrichment at site, thereby reducing side effects enhancing efficacy. Nanozymes also be used as tracking imaging reshape microenvironment, providing a versatile platform treatment malignancies. this paper, we review current status on oncology analyze novel therapeutic approaches mechanisms. To date, large number nanomaterials, such noble metal nonmetallic carbon-based have been shown able function like natural enzymes, particularly with significant advantages therapy. light this, authors systematically summarized evaluated construction, enzymatic activity, characteristics nanozymes respect modalities addition, application different types nicknames features years are detail. We conclude summary outlook study It hoped that will inspire researchers fields chemistry, biology, materials science contribute nano-enzymology.

Language: Английский

Citations

13
Nanozymes with biomimetically designed properties for cancer treatment DOI Creative Commons
Ke Xu, Yujie Cui, Bin Guan

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(16), P. 7786 - 7824

Published: Jan. 1, 2024

The therapeutic efficacy of nanozymes, which have wide applications in cancer treatment, can be enhanced by various biomimetic design strategies, from structural and process mimicry to advanced functional biomimicry.

Language: Английский

Citations

11
In Situ Redox of TiSe2 Nanoplates to Excite Chemodynamic‐Enhanced Cancer Sono‐Immunotherapy DOI Creative Commons

Xialing He,

Jinming Cai, Jinyan Hu

et al.

Small Structures, Journal Year: 2024, Volume and Issue: 5(6)

Published: Feb. 22, 2024

Different from the direct delivery of chemodynamic agents into tumor tissue for therapy (CDT), this work reports fabrication heterojunction sonosensitizers (CD/TiSe 2 ) in situ generation by responding to microenvironment (TME), realizing CDT‐enhanced sono‐immunotherapy. The redox TiSe acidic TME leads formation TiO x Se 2− containing (0), selenate, and Ti 3+ /Ti 4+ couple, which can facilitate CDT through a ‐mediated Fenton‐like reaction consume overexpressed glutathione (GSH) via GSH depletion. Moreover, ions generated process promote maturation dendritic cells, consequently activating adaptive immune responses. In another aspect, construction heterojunctions within carbon dots improves reactive oxygen species (ROS) efficiency cascaded manner, enhances sonodynamic activity amplifies performance. More importantly, ROS produced efficiently triggers immunogenic cell death synergistic based on elicitation antitumor immunity with aid an checkpoint blockade. This thus provides distinct paradigm transition metal selenide‐originated agent

Language: Английский

Citations

10
Computer-aided nanodrug discovery: recent progress and future prospects DOI Creative Commons
Jia‐Jia Zheng, Qiao-Zhi Li, Zhenzhen Wang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(18), P. 9059 - 9132

Published: Jan. 1, 2024

Nanodrugs, which utilise nanomaterials in disease prevention and therapy, have attracted considerable interest since their initial conceptualisation the 1990s. Substantial efforts been made to develop nanodrugs for overcoming limitations of conventional drugs, such as low targeting efficacy, high dosage toxicity, potential drug resistance. Despite significant progress that has nanodrug discovery, precise design or screening with desired biomedical functions prior experimentation remains a challenge. This is particularly case regard personalised precision nanodrugs, require simultaneous optimisation structures, compositions, surface functionalities nanodrugs. The development powerful computer clusters algorithms it possible overcome this challenge through

Language: Английский

Citations

9
Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer DOI Creative Commons

Yuwei Yao,

Jiarui Zhang,

Kexin Huang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 5, 2025

The efficacy of current therapies for ovarian cancer is limited due to the multilevel and complex tumor microenvironment (TME), which induces drug resistance progression in a single treatment regimen. Additionally, poor targeting insufficient tissue penetration are important constraints treatment. We constructed PH20-overexpressing cancer-associated fibroblast (CAF)-cancer hybrid-cell membrane vesicles (PH20/CCM) dual-targeted delivery carboplatin (CBP) siRNA p65 (sip65) loaded on poly (dimethyl diallyl ammonium chloride) (PDDA)-modified MXene (PMXene), named PMXene@CBP-sip65 (PMCS). nanoparticle PH20/CCM@PMCS could penetrate extracellular matrix tissues target both cells CAFs. After cell internalization, these nanoparticles significantly inhibited proliferation, generated reactive oxygen species, induced endoplasmic reticulum stress, triggered immunogenic death. CAF they pro-tumor factor release activated immune effects, promoting system infiltration. In an experiment with ID8 homograft-carrying mice, improved inhibition enhanced infiltration tissues. These new therapeutic can simultaneously cells, CAFs, matrix, thereby increasing sensitivity improving TME. Therefore, TME-regulating nanoparticles, combining specificity, efficiency, effectiveness, provide insights into

Language: Английский

Citations

1
Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness DOI Creative Commons
Xuran Zhang, Jian Wang, Qingqing Feng

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 11, 2025

The application of photodynamic therapy (PDT) is limited by unsatisfactory therapeutic efficacy and dose-dependent phototoxicity in clinical settings. Intravenous nano-drug delivery systems (NDDSs) hold promise for enhancing the efficiency photosensitive drugs, but often result aggregation-caused quenching (ACQ) effects, preventing site-specific activation. We exploited manganese (Mn2+)-pyrochloric acid (PPa) nanocomplexes coordinated using photosensitizer PPa metal Mn ion treatment osteosarcoma. were precisely co-assembled water to stably co-deliver Mn2+ PPa, enabling tumor-specific release fluorescence recovery. Following laser irradiation, activated significantly enhanced killing effects on primary cancer cells. Additionally, ions cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway, promoting maturation dendritic cells (DCs) augmenting CD8+-mediated antitumor immune responses. This study advances on-demand activation drugs immunotherapy toward applicability exploiting Mn2+-PPa with high activatability effectiveness targeted PDT immunotherapy.

Language: Английский

Citations

1
Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review DOI
Xing Yang, Feroza Yasinjan,

Shuhao Sun

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102386 - 102386

Published: July 13, 2024

Language: Английский

Citations

7
MXene‐Mediated Catalytic Redox Reactions for Biomedical Applications DOI
Chenyao Wu, Lili Xia, Wei Feng

et al.

ChemPlusChem, Journal Year: 2024, Volume and Issue: 89(6)

Published: Feb. 15, 2024

Reactive oxygen species (ROS) play a crucial role in orchestrating myriad of physiological processes within living systems. With the advent materdicine, an array nanomaterials has been intricately engineered to influence redox equilibrium biological milieus, thereby pioneering distinctive therapeutic paradigm predicated on ROS-centric biochemistry. Among these, two-dimensional carbides, nitrides, and carbonitrides, collectively known as MXenes, stand out due their multi-valent multi-elemental compositions, large surface area, high conductivity, pronounced local plasmon resonance effects, positioning them prominent contributors ROS modulation. This review aims provide overview advancements harnessing MXenes for catalytic reactions various applications, including tumor, anti-infective, anti-inflammatory therapies. The emphasis lies elucidating mechanism involving both pro-oxidation anti-oxidation processes, underscoring redox-related applications facilitated by self-catalysis, photo-excitation, sono-excitation properties MXenes. Furthermore, this highlights existing challenges outlines future development trends leveraging ROS-involving disease treatments, marking significant step towards integration these into clinical practice.

Language: Английский

Citations

6
Au Nanorods Activated the Zn/Ce Composites with Cancer Cell Specific Cytotoxicity for Enhanced Chemodynamic Therapy DOI

Chengcheng Feng,

Zheng Wang,

Yechun Jiang

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 24(1), P. 295 - 304

Published: Dec. 20, 2023

Chemodynamic therapy based on the Fenton reaction has been developed as an extremely promising modality for cancer therapeutics. In this study, a core–shell structure nanoplatform was constructed by Au nanorod externally encapsulating Ce/Zn-based composites (ACZO). The nanoparticles can catalyze generation of reactive oxygen species (ROS) under acidic conditions and effectively consume existing glutathione (GSH) to destroy redox balance within tumor. Moreover, decomposition nanocomplexes releases large amounts zinc ions, leading overload in cells. photothermal effect generated nanorods not only provides (PTT) but also augments catalytic ions action mentioned above. This facile strategy improve efficacy chemodynamic enhancement activity ion release perspective potential tumor treatment.

Language: Английский

Citations

14