The
proper
organization
of
cells
and
tissues
is
essential
for
their
functionalization
in
living
organisms.
To
create
materials
that
mimic
natural
structures,
researchers
have
developed
techniques
such
as
patterning,
templating,
printing.
Although
these
own
several
advantages,
processes
still
involve
complexity,
are
time-consuming,
high
cost.
better
simulate
with
micro/nanostructures
evolved
millions
years,
the
use
ice
templates
has
emerged
a
promising
method
producing
biomimetic
more
efficiently.
This
article
explores
historical
approaches
taken
to
produce
traditional
structural
biomaterials
delves
into
principles
underlying
ice-template
various
applications
creation
materials.
It
also
discusses
most
recent
biomedical
uses
created
via
templates,
including
porous
microcarriers,
tissue
engineering
scaffolds,
smart
Finally,
challenges
potential
current
technology
analyzed.
The
extracellular
matrix
(ECM)
governs
a
wide
spectrum
of
cellular
fate
processes,
with
particular
emphasis
on
anoikis,
an
integrin-dependent
form
cell
death.
Currently,
anoikis
is
defined
as
intrinsic
apoptosis.
In
contrast
to
traditional
apoptosis
and
necroptosis,
integrin
correlates
ECM
signaling
intracellular
cascades,
describing
the
full
process
anoikis.
However,
frequently
overlooked
in
physiological
pathological
processes
well
vitro
research
models.
this
review,
we
summarized
role
spanning
embryonic
development,
organ
tissue
repair,
inflammatory
responses,
cardiovascular
diseases,
tumor
metastasis,
so
on.
Similarly,
realm
stem
focused
functional
evolution
cells,
offers
potential
solution
various
challenges,
including
culture
models,
therapy,
transplantation,
engineering
applications,
which
are
largely
based
regulation
by
More
importantly,
regulatory
mechanisms
molecular
will
provide
new
strategies
for
therapeutic
interventions
(drug
therapy
cell-based
therapy)
disease.
summary,
review
provides
systematic
elaboration
thus
shedding
light
its
future
research.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 5, 2025
Pulmonary
fibrosis
(PF)
is
a
common
and
multidimensional
devastating
interstitial
lung
disease.
The
development
of
novel
more
effective
interventions
for
PF
an
urgent
clinical
need.
A
previous
study
has
found
that
miR-181a-5p
plays
important
role
in
the
PF,
human
amniotic
mesenchymal
stem
cells
(hAMSCs)
exert
potent
therapeutic
potential
on
PF.
However,
whether
hAMSCs
act
by
delivering
its
detailed
mechanism
still
remain
unknown.
Thus,
this
was
designed
to
investigate
underlying
possible
bleomycin
(BLM)-induced
mouse
model,
co-culture
system
A549
epithelial
transition
(EMT)
focusing
effects
collagen
deposition,
EMT,
cell
cycle
regulation.
with
different
expression
levels
were
constructed.
BLM
(4
mg/kg)
used
create
while
TGF-β1
induce
construct
EMT
model.
Furthermore,
deposition
during
assessed
vivo
vitro.
We
exerted
anti-fibrotic
effect
BLM-induced
Moreover,
also
protective
TGFβ1-induced
ameliorated
promoting
proliferation,
reducing
apoptosis,
attenuating
through
paracrine
effects.
regulated
targeting
TGFBR1.
Our
findings
reveal
first
time
inhibit
EMT.
Mechanistically,
hMASCs
achieved
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Июль 4, 2023
The
incidence
of
tissue
and
organ
damage
caused
by
various
diseases
is
increasing
worldwide.
Tissue
engineering
a
promising
strategy
tackling
this
problem
because
its
potential
to
regenerate
or
replace
damaged
tissues
organs.
biochemical
biophysical
cues
biomaterials
can
stimulate
induce
biological
activities
such
as
cell
adhesion,
proliferation
differentiation,
ultimately
achieve
repair
regeneration.
Micro/nano
materials
are
special
type
biomaterial
that
mimic
the
microstructure
on
microscopic
scale
due
precise
construction,
further
providing
scaffolds
with
specific
three-dimensional
structures
guide
cells.
study
application
biomimetic
micro/nano-materials
have
greatly
promoted
development
engineering.
This
review
aims
provide
an
overview
different
types
micro/nanomaterials,
their
preparation
methods
in
The
proper
organization
of
cells
and
tissues
is
essential
for
their
functionalization
in
living
organisms.
To
create
materials
that
mimic
natural
structures,
researchers
have
developed
techniques
such
as
patterning,
templating,
printing.
Although
these
own
several
advantages,
processes
still
involve
complexity,
are
time-consuming,
high
cost.
better
simulate
with
micro/nanostructures
evolved
millions
years,
the
use
ice
templates
has
emerged
a
promising
method
producing
biomimetic
more
efficiently.
This
article
explores
historical
approaches
taken
to
produce
traditional
structural
biomaterials
delves
into
principles
underlying
ice-template
various
applications
creation
materials.
It
also
discusses
most
recent
biomedical
uses
created
via
templates,
including
porous
microcarriers,
tissue
engineering
scaffolds,
smart
Finally,
challenges
potential
current
technology
analyzed.
