A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

Advanced Science, Год журнала: 2023, Номер 10(30)

Опубликована: Сен. 13, 2023

Hydrogels are used in wound dressings because of their tissue-like softness and biocompatibility. However, the clinical translation hydrogels remains challenging long-term stability, water swellability, poor tissue adhesiveness. Here, tannic acid (TA) is introduced into a double network (DN) hydrogel consisting poly(vinyl alcohol) (PVA) poly(acrylic acid) (PAA) to realize tough, self-healable, nonswellable, conformally tissue-adhesive, hemostatic, antibacterial hydrogel. The TA within DN forms dynamic network, enabling rapid self-healing (within 5 min) offering effective energy dissipation for toughness viscoelasticity. Furthermore, hydrophobic moieties provide water-shielding effect, rendering nonswellable. A simple chemical modification further strengthens its interfacial adhesion with tissues (shear strength ≈31 kPa). Interestingly, also can serve as an hemostatic (blood-clotting index 58.40 ± 1.5) component, which required successful dressing. effects tested against Escherichia coli Staphylococcus aureus. Finally, prepared patch form applied mouse model test vivo biocompatibility performances.

Язык: Английский

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Dual Glucose/ROS-Sensitive Injectable Adhesive Self-Healing Hydrogel with Photothermal Antibacterial Activity and Modulation of Macrophage Polarization for Infected Diabetic Wound Healing

ACS Materials Letters, Год журнала: 2023, Номер 5(12), С. 3142 - 3155

Опубликована: Окт. 27, 2023

Antibacterial, anti-inflammatory, and healing-promoting treatment of chronically infected wounds is not only clinical problems to be solved urgently but also important needs related people's livelihood. However, multifunctional hydrogel dressings with highly efficient antibacterial, wound microenvironment sensitive drug release performance still remain a challenge. In this work, dressing was achieved by introducing mussel-like super adhesion catechol groups glucose/ROS-sensitive dynamic phenylboronester bond cross-linking network, which endowed the excellent injectable, self-healing, tissue properties, performance. Additionally, high-efficiency photothermal synergistic antibacterial TP@Ag NPs were prepared introduced into hydrogel. The glucose/ROS responsive borate in network could realize NPs, thereby promoting M2 polarization achieve an anti-inflammatory effect. And excess reactive oxygen (ROS) scavenged effect group ROS-sensitive Moreover, biocompatibility antioxidant shown hydrogels. Finally, fully fill adhere irregular through injection significantly promote diabetic healing vivo sterilization, ROS scavenging ability, modulation macrophage reduce inflammatory response. Thus, it illustrated superiority as advanced functional for healing.

Язык: Английский

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Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 319, С. 102982 - 102982

Опубликована: Авг. 13, 2023

Язык: Английский

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Modulating macrophage phenotype for accelerated wound healing with chlorogenic acid-loaded nanocomposite hydrogel

Journal of Controlled Release, Год журнала: 2024, Номер 369, С. 420 - 443

Опубликована: Апрель 5, 2024

Язык: Английский

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Bio‐Inspired Porous Microneedles Dwelled Stem Cells for Diabetic Wound Treatment

Advanced Functional Materials, Год журнала: 2024, Номер 34(28)

Опубликована: Фев. 6, 2024

Abstract Diabetic wound healing is a serious, complex, and chronic process; one current promising focusing technology in this area stem cell treatment. Here, novel porous microneedle (MN) arrays fabricated, which can highly mimetic niches, through template filling, particle etching method. The human adipose‐derived cells (ADSCs) are encapsulated Matrigel then loaded into the MN by post‐perfusion. Because of extracellular matrix‐mimicking, biocompatible offers bionic microenvironment nest suitable for growth. Benefiting from numerous pore structures MNs, ADSCs have enough space to fully absorb nutrients, proliferate greatly exhibit prompted function. In addition, cell‐loaded mechanical strength penetrate skin, allowing get deep areas. Based on these features, performance resultant promoting tissue regeneration demonstrated, collagen deposition angiogenesis diabetes wounds rat models. Thus, it believe that bioinspired MNs act as excellent scaffolds will find many practical values clinic healing.

Язык: Английский

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Recent advances of hydrogels as smart dressings for diabetic wounds

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(5), С. 1126 - 1148

Опубликована: Янв. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Язык: Английский

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Mechanical Stimulation of Anti‐Inflammatory and Antioxidant Hydrogels for Rapid Re‐Epithelialization

Advanced Materials, Год журнала: 2024, Номер 36(18)

Опубликована: Янв. 26, 2024

Abstract The epithelium, an essential barrier to protect organisms against infection, exists in many organs. However, rapid re‐epithelialization restore tissue integrity and function adverse environment is challenging. In this work, a long‐term anti‐inflammatory antioxidant hydrogel with mechanical stimulation for re‐epithelialization, mainly composed of the small molecule thioctic acid, biocompatible glycine, γ‐Fe 2 O 3 nanoparticles reported. Glycine‐modified supramolecular acid stable possesses outstanding properties. incorporating providing potential contrast magnetic resonance imaging observation, can propel reconfiguration enhance properties underwater due water‐initiated release Fe 3+ . vitro experiments show that hydrogels effectively reduced intracellular reactive oxygen species, guided macrophages toward M2 polarization, alleviated inflammation. effect ultimately demonstrated long urethral injury model vivo, achieves effective functional replacement accurate remodeling epithelium. Notably, proposed strategy provides advanced alternative treatment patients need large‐area epithelial reconstruction.

Язык: Английский

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Injectable hemostatic hydrogel adhesive with antioxidant, antibacterial and procoagulant properties for hemorrhage wound management

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 673, С. 395 - 410

Опубликована: Июнь 6, 2024

Язык: Английский

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Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Авг. 10, 2023

Abstract Bacterial infections can significantly impede wound healing and pose a serious threat to the patient’s life. The excessive use of antibiotics combat bacterial has led emergence multi-drug-resistant bacteria. Therefore, there is pressing need for alternative approaches, such as photothermal therapy (PTT), address this issue. In study, first time, CuS NPs with properties were synthesized using sericin biological template, named CuS@Ser NPs. This method simple, green, does not produce toxic harmful by-products. These nanoparticles incorporated into mixture (XK) xanthan gum konjac glucomannan (KGM) obtain XK/CuS composite hydrogel, which could overcome limitations current dressings. hydrogel exhibited excellent mechanical flexibility, response, biocompatibility. It also demonstrated potent antibacterial against both Gram-positive negative bacteria via experiments accelerated in animal models. Additionally, it proved that promoted tissue regeneration by stimulating collagen deposition, angiogenesis, reducing inflammation. summary, presents promising clinical management infected wounds, offering new approach promote healing.

Язык: Английский

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A Versatile Chitosan‐Based Hydrogel Accelerates Infected Wound Healing via Bacterial Elimination, Antioxidation, Immunoregulation, and Angiogenesis

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)

Опубликована: Фев. 26, 2024

Abstract Drug‐resistant bacterial infection of cutaneous wounds causes great harm to the human body. These infections are characterized by a microenvironment with recalcitrant infections, persistent oxidative stress, imbalance immune regulation, and suboptimal angiogenesis. Treatment strategies available date incapable handling healing dynamics infected wounds. A Schiff base borate ester cross‐linked hydrogel, based on phenylboronic acid‐grafted chitosan (CS‐PBA), dibenzaldehyde‐grafted poly(ethylene glycol), tannic acid (TA), is fabricated in present study. Customized acid‐modified zinc oxide nanoparticles (ZnO) embedded hydrogel prior gelation. The CPP@ZnO‐P‐TA effectively eliminates methicillin‐resistant Staphylococcus aureus (MRSA) due pH‐responsive release Zn 2+ TA. Killing achieved via membrane damage, adenosine triphosphate reduction, leakage intracellular components, hydrolysis o ‐nitrophenyl‐β‐ d ‐galactopyranoside. capable scavenging reactive oxygen nitrogen species, alleviating stimulating M2 polarization macrophages. released TA also induce neovascularization PI3K/Akt pathway. improves tissue regeneration vivo inflammatory responses, angiogenesis, facilitating collagen deposition. findings suggest that this versatile possesses therapeutic potential for treatment MRSA‐infected

Язык: Английский

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