Analytical Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Hepatic
ischemia-reperfusion
injury
(HIRI)
and
induced
systemic
inflammation
is
a
time-dependent
multistage
process
which
poses
risk
of
causing
direct
hepatic
dysfunction
multiorgan
failure.
Real-time
in
situ
comprehensive
visualization
assessment
important
scarce
for
imaging-guided
therapeutic
interventions
timely
efficacy
evaluation.
Here,
logically
activatable
nanoreporter
(termed
QD@IR783-TK-FITC)
developed
time-phase
imaging
quantification
HIRI
inflammation.
The
nanoreporters
could
be
used
vivo
ratiometric
NIR-IIb
fluorescence
sensing
reactive
oxygen
species
(ROS),
can
depict
the
ROS
fluctuation
early
diagnosis
initial
3
h.
Meanwhile,
ROS-specific
reaction
releases
renal-clearable
fluorophore
fragments
from
monitoring
systematic
by
via
longitudinal
urinalysis.
In
addition,
functional
relationship
between
digitized
signal
outputs
(NIR-IIb
ratios,
urinary
fluorescence)
with
scores
has
been
established,
realizing
precise
prediction
severity
preassessment
efficacy.
Such
time-phased
modular
toolbox
dynamically
report
HIRI-induced
vivo,
providing
an
efficient
approach
treatment.
Green Chemistry,
Год журнала:
2024,
Номер
26(6), С. 2985 - 3020
Опубликована: Янв. 1, 2024
Se
doping
endows
carbon
materials
with
rich
and
versatile
chemistry,
thus
transforming
them
into
functional
for
sustainable
technologies
such
as
heterogeneous
(electro)catalysis,
energy
conversion/storage
devices,
pollutant
removal.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 20, 2024
Abstract
Spinal
cord
injury
(SCI)
often
results
in
motor
and
sensory
deficits,
or
even
paralysis.
Due
to
the
role
of
cascade
reaction,
effect
excessive
reactive
oxygen
species
(ROS)
early
middle
stages
SCI
severely
damage
neurons,
most
antioxidants
cannot
consistently
eliminate
ROS
at
non-toxic
doses,
which
leads
a
huge
compromise
antioxidant
treatment
SCI.
Selenium
nanoparticles
(SeNPs)
have
excellent
scavenging
bioactivity,
but
toxicity
control
problem
limits
therapeutic
window.
Here,
we
propose
synergistic
strategy
SeNPs
encapsulated
by
ZIF-8
(SeNPs@ZIF-8)
obtain
activity.
Three
different
spatial
structures
SeNPs@ZIF-8
were
synthesized
coated
with
ferrostatin-1,
ferroptosis
inhibitor
(FSZ
NPs),
achieve
enhanced
anti-oxidant
anti-ferroptosis
activity
without
toxicity.
FSZ
NPs
promoted
maintenance
mitochondrial
homeostasis,
thereby
regulating
expression
inflammatory
factors
promoting
polarization
macrophages
into
M2
phenotype.
In
addition,
presented
strong
abilities
promote
neuronal
maturation
axon
growth
through
activating
WNT4-dependent
pathways,
while
prevented
glial
scar
formation.
The
current
study
demonstrates
powerful
versatile
bioactive
functions
for
offers
inspiration
other
neural
diseases.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(29)
Опубликована: Июль 22, 2024
Reactive
oxygen
species
(ROS),
as
metabolic
byproducts,
play
pivotal
role
in
physiological
and
pathological
processes.
Recently,
studies
on
the
regulation
of
ROS
levels
for
disease
treatments
have
attracted
extensive
attention,
mainly
involving
ROS-induced
toxicity
therapy
mediated
by
producers
antioxidant
scavengers.
Nanotechnology
advancements
led
to
development
numerous
nanomaterials
with
ROS-modulating
capabilities,
among
which
carbon
dots
(CDs)
standing
out
noteworthy
nanomedicines
own
their
distinctive
physicochemical
properties,
high
stability,
excellent
biocompatibility.
Despite
progress
treating
ROS-related
diseases
based
CDs,
critical
issues
such
rational
design
principles
remain
underexplored.
The
primary
cause
these
may
stem
from
intricate
amalgamation
core
structure,
defects,
surface
states,
inherent
poses
challenges
establishing
a
consistent
generalization.
This
review
succinctly
summarizes
recently
ROS-modulated
approaches
using
CDs
treatment.
Specifically,
it
investigates
established
therapeutic
strategies
CDs-regulated
ROS,
emphasizing
interplay
between
intrinsic
structure
generation
or
scavenging
ability.
conclusion
raises
several
unresolved
key
scientific
prominent
technological
bottlenecks,
explores
future
perspectives
comprehensive
CDs-based
therapy.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 7901 - 7922
Опубликована: Дек. 1, 2023
Abstract:
Acute
liver
injury
(AIL),
a
fatal
clinical
disease
featured
with
swift
deterioration
of
hepatocyte
functions
in
the
short
term,
has
emerged
as
serious
public
health
issues
that
warrants
attention.
However,
effectiveness
existing
small
molecular
antioxidants
and
anti-inflammatory
medications
alleviating
AIL
remains
uncertain.
The
unique
inherent
structural
characteristics
confer
it
natural
propensity
for
nanoparticle
capture,
which
present
an
opportunity
to
exploit
formulation
nanoscale
therapeutic
agents,
enabling
their
selective
accumulation
thereby
facilitating
targeted
interventions.
Significantly
increased
reactive
oxygen
species
(ROS)
inflammation
response
have
been
evidenced
play
crucial
roles
occurrence
development
AIL.
Nanozymes
ROS-scavenging
capacities
demonstrated
considerable
promise
ROS
elimination
regulation,
offering
appealing
instrument
management
acute
injury.
In
this
review,
mechanisms
different
type
ALI
were
summarized.
addition,
we
provide
comprehensive
summary
review
available
nanozymes,
including
transition
metal-based
noble
metal
carbon-based
some
other
nanozymes.
Furthermore,
challenges
still
need
be
solved
field
nanozymes
alleviation
are
also
discussed.
Keywords:
injury,
nanozyme,
ROS-scavenging,
antioxidant,
anti-inflammation
