Logically Activatable Nanoreporter for Multiplexed Time-Phased Imaging Assessment of Hepatic Ischemia-Reperfusion Injury and Systemic Inflammation DOI
Tao Tang,

Fushou Liu,

Biao Huang

и другие.

Analytical Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Hepatic ischemia-reperfusion injury (HIRI) and induced systemic inflammation is a time-dependent multistage process which poses risk of causing direct hepatic dysfunction multiorgan failure. Real-time in situ comprehensive visualization assessment important scarce for imaging-guided therapeutic interventions timely efficacy evaluation. Here, logically activatable nanoreporter (termed QD@IR783-TK-FITC) developed time-phase imaging quantification HIRI inflammation. The nanoreporters could be used vivo ratiometric NIR-IIb fluorescence sensing reactive oxygen species (ROS), can depict the ROS fluctuation early diagnosis initial 3 h. Meanwhile, ROS-specific reaction releases renal-clearable fluorophore fragments from monitoring systematic by via longitudinal urinalysis. In addition, functional relationship between digitized signal outputs (NIR-IIb ratios, urinary fluorescence) with scores has been established, realizing precise prediction severity preassessment efficacy. Such time-phased modular toolbox dynamically report HIRI-induced vivo, providing an efficient approach treatment.

Язык: Английский

Recent advances in carbon dots-based nanoplatforms: Physicochemical properties and biomedical applications DOI

Shiqiao Rui,

Luming Song,

Jiaru Lan

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 476, С. 146593 - 146593

Опубликована: Окт. 10, 2023

Язык: Английский

Процитировано

29

Selenium-doped carbon materials: synthesis and applications for sustainable technologies DOI
Sławomir Dyjak, Bartłomiej Jankiewicz, Stanisław Kaniecki

и другие.

Green Chemistry, Год журнала: 2024, Номер 26(6), С. 2985 - 3020

Опубликована: Янв. 1, 2024

Se doping endows carbon materials with rich and versatile chemistry, thus transforming them into functional for sustainable technologies such as heterogeneous (electro)catalysis, energy conversion/storage devices, pollutant removal.

Язык: Английский

Процитировано

8

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform DOI Creative Commons

Heng Zhou,

Ziwei Li, Shuili Jing

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 20, 2024

Abstract Spinal cord injury (SCI) often results in motor and sensory deficits, or even paralysis. Due to the role of cascade reaction, effect excessive reactive oxygen species (ROS) early middle stages SCI severely damage neurons, most antioxidants cannot consistently eliminate ROS at non-toxic doses, which leads a huge compromise antioxidant treatment SCI. Selenium nanoparticles (SeNPs) have excellent scavenging bioactivity, but toxicity control problem limits therapeutic window. Here, we propose synergistic strategy SeNPs encapsulated by ZIF-8 (SeNPs@ZIF-8) obtain activity. Three different spatial structures SeNPs@ZIF-8 were synthesized coated with ferrostatin-1, ferroptosis inhibitor (FSZ NPs), achieve enhanced anti-oxidant anti-ferroptosis activity without toxicity. FSZ NPs promoted maintenance mitochondrial homeostasis, thereby regulating expression inflammatory factors promoting polarization macrophages into M2 phenotype. In addition, presented strong abilities promote neuronal maturation axon growth through activating WNT4-dependent pathways, while prevented glial scar formation. The current study demonstrates powerful versatile bioactive functions for offers inspiration other neural diseases.

Язык: Английский

Процитировано

8

Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers? DOI
Chen Dong, Yanan Wang, Tianxiang Chen

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)

Опубликована: Июль 22, 2024

Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving ROS-induced toxicity therapy mediated by producers antioxidant scavengers. Nanotechnology advancements led to development numerous nanomaterials with ROS-modulating capabilities, among which carbon dots (CDs) standing out noteworthy nanomedicines own their distinctive physicochemical properties, high stability, excellent biocompatibility. Despite progress treating ROS-related diseases based CDs, critical issues such rational design principles remain underexplored. The primary cause these may stem from intricate amalgamation core structure, defects, surface states, inherent poses challenges establishing a consistent generalization. This review succinctly summarizes recently ROS-modulated approaches using CDs treatment. Specifically, it investigates established therapeutic strategies CDs-regulated ROS, emphasizing interplay between intrinsic structure generation or scavenging ability. conclusion raises several unresolved key scientific prominent technological bottlenecks, explores future perspectives comprehensive CDs-based therapy.

Язык: Английский

Процитировано

7

Revolutionary carbon quantum dots and their applications: A theoretical computations perspective DOI
Fanyong Yan, Tingting Meng, Jinxia Xu

и другие.

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113392 - 113392

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Multifunctional Dual-Layer Microneedles Loaded with Selenium-Doped Carbon Quantum Dots and Astilbin for Ameliorating Diabetic Wound Healing DOI Creative Commons
Zhen Zhang, Yulin Zhang,

Liang Peng

и другие.

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101739 - 101739

Опубликована: Апрель 1, 2025

Diabetic wounds (DW) represent a significant clinical challenge due to chronic inflammation, excessive oxidative stress, and impaired angiogenesis, all of which hinder effective tissue regeneration. Existing drug delivery systems often fail achieve sustained targeted therapeutic efficacy. In this study, we developed novel dissolvable dual-layer methacrylated gelatin (GelMA) microneedle (MN) co-loading selenium-doped carbon quantum dots (Se-CQDs) Astilbin (AST) for enhanced DW treatment. The outer layer, enriched with Se-CQDs, rapidly scavenges reactive oxygen species (ROS), effectively alleviating stress at the wound site. Sequentially, inner layer releases AST, exerting potent anti-inflammatory pro-angiogenic effects. Preliminary findings suggest these effects may involve modulation cytoskeletal dynamics peroxisome function, contributing endothelial cell migration angiogenesis. This controlled, sequential release MN establishes low-oxidative, microenvironment, thereby promoting angiogenesis accelerating repair. pioneering integration AST-loaded hydrogels offers synergistic strategy, setting new standard advanced diabetic care substantial promise.

Язык: Английский

Процитировано

0

Defect-engineered nanoscale metal-organic frameworks as self-cascade antioxidation nanozymes for targeted therapy of cisplatin-induced acute kidney injury DOI

Wenfeng Guo,

Tingting Wang,

Huirong Li

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163893 - 163893

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

An orally deliverable ornithine-based self-assembling polymer nanomedicine ameliorates hyperammonemia in acetaminophen-induced acute liver injury DOI Open Access
Yuanyuan Ding, Yuta Koda, Babita Shashni

и другие.

Acta Biomaterialia, Год журнала: 2023, Номер 168, С. 515 - 528

Опубликована: Июль 9, 2023

Язык: Английский

Процитировано

6

Reactive Oxygen Species Scavenging Nanozymes: Emerging Therapeutics for Acute Liver Injury Alleviation DOI Creative Commons
Tao Sun,

Shilin Xiao,

Miaomiao Wang

и другие.

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 7901 - 7922

Опубликована: Дек. 1, 2023

Abstract: Acute liver injury (AIL), a fatal clinical disease featured with swift deterioration of hepatocyte functions in the short term, has emerged as serious public health issues that warrants attention. However, effectiveness existing small molecular antioxidants and anti-inflammatory medications alleviating AIL remains uncertain. The unique inherent structural characteristics confer it natural propensity for nanoparticle capture, which present an opportunity to exploit formulation nanoscale therapeutic agents, enabling their selective accumulation thereby facilitating targeted interventions. Significantly increased reactive oxygen species (ROS) inflammation response have been evidenced play crucial roles occurrence development AIL. Nanozymes ROS-scavenging capacities demonstrated considerable promise ROS elimination regulation, offering appealing instrument management acute injury. In this review, mechanisms different type ALI were summarized. addition, we provide comprehensive summary review available nanozymes, including transition metal-based noble metal carbon-based some other nanozymes. Furthermore, challenges still need be solved field nanozymes alleviation are also discussed. Keywords: injury, nanozyme, ROS-scavenging, antioxidant, anti-inflammation

Язык: Английский

Процитировано

6

Multifunctional selenium-doped carbon dots for modulating Alzheimer's disease related toxic ions, inhibiting amyloid aggregation and scavenging reactive oxygen species DOI
Xu Shao,

Tiange Fan,

Chaoren Yan

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139333 - 139333

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

2