Preparation of edible antibacterial films based on corn starch /carbon nanodots for bioactive food packaging

Food Chemistry, Год журнала: 2024, Номер 444, С. 138467 - 138467

Опубликована: Янв. 18, 2024

Язык: Английский

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Biophilic Positive Carbon Dot Exerts Antifungal Activity and Augments Corneal Permeation for Fungal Keratitis

Nano Letters, Год журнала: 2024, Номер 24(13), С. 4044 - 4053

Опубликована: Март 22, 2024

Fungal keratitis (FK) is an infectious eye disease that poses a significant risk of blindness. However, the effectiveness conventional antifungal drugs limited due to intrinsic ocular barrier impedes drug absorption. There urgent need develop new therapeutic strategies effectively combat FK. Herein, we synthesized ultrasmall positively charged carbon dot using simple stage-melting method. The can penetrate corneal by opening tight junctions, allowing them reach lesion site and kill fungi. results both in vitro vivo demonstrated it exhibited good biocompatibility activity, significantly improving effect mouse model Therefore, this biophilic size positive dot, characterized its ability properties, may offer valuable insights into design effective nanomedicines.

Язык: Английский

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Depolymerizable Enzymatic Cascade Nanoreactor for Self‐Enhancing Targeting Synergistic Tumor Therapy

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Abstract Traditional targeting strategies require nanoparticles (NPs) to penetrate the vascular wall bind tumor cell surface receptors, resulting in a small proportion of drugs that achieve delivery. Based on this, novel design self‐enhancing sites has been proposed and needs meet two preconditions: 1) It can efficiently P‐selectin overexpressed by activated endothelial cells. 2) release reactive oxygen species (ROS) site activate resting cells, thus providing more targets for subsequent preparations. Besides, overcome limited penetration site, variable‐size system be designed. Red light carbon dots nanozyme (Fe(III)‐CDs) glucose oxidase (GOx) are combined form enzymatic cascade nanoreactor FG. As natural ligand P‐selectin, fucoidan (Fu) is coated L‐arginine‐composite FG obtain FGA@Fu. demonstrated FGA@Fu realize weak acid/photothermal responsive depolymerization enhance tumors with controlled ROS release. Inspiringly, “targeting‐activation‐(self‐enhanced targeting)” vasculature good fluorescence tracking. In vivo anti‐tumor experiments showed excellent enzyme catalysis/gas/photothermal combination therapy effect strong inhibition metastasis.

Язык: Английский

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Advancements in the synthesis of carbon dots and their application in biomedicine

Journal of Photochemistry and Photobiology B Biology, Год журнала: 2024, Номер 255, С. 112920 - 112920

Опубликована: Апрель 21, 2024

Язык: Английский

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Multimodal biomedical utility of polyaniline-based supramolecular nanomaterials

Chemical Engineering Journal, Год журнала: 2024, Номер 493, С. 152530 - 152530

Опубликована: Май 24, 2024

Язык: Английский

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Rational construction of CQDs-based targeted multifunctional nanoplatform for synergistic chemo-photothermal tumor therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 677, С. 79 - 90

Опубликована: Авг. 8, 2024

Photothermal therapy combined with chemotherapy has shown great promise in the treatment of cancer. In this synergistic system, a safe, stable, and efficient photothermal agent is desired. Herein, an effective agent, carbon quantum dots (CQDs), was initially synthesized then rationally constructed folic acid (FA)-targeted multifunctional nanoplatform by encapsulating CQDs anticancer drug doxorubicin (DOX) liposomes. Indocyanine green (ICG), near infrared (NIR) approved U.S. Food Drug Administration, embedded bilayer membrane to further enhance effects facilitate rapid cleavage liposomes for release. Triggered NIR laser, engineered nanoplatform, not only exhibited excellent performance conversion efficiency up 47.14%, but also achieved controlled release payloads. vitro, vivo experiments demonstrated that had biocompatibility, enhanced tumor-specific targeting, stimuli-responsive release, cancer cell killing tumor suppression through multi-modal therapy. The successful construction light-triggered targeted will provide promising strategy design development chemo-photothermal combination improve therapeutic efficacy treatment.

Язык: Английский

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Photophysical Characterization and Theoretical Analysis of Brilliant Sulfaflavine Dye: Experimental and DFT Approaches

Next research., Год журнала: 2025, Номер unknown, С. 100146 - 100146

Опубликована: Янв. 1, 2025

Язык: Английский

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An integrated and multifunctional homemade cell sensor platform based on Si-d-CQDs and CRISPR-Cas12a for CD31 detection during endothelial-to-mesenchymal transition

Talanta, Год журнала: 2025, Номер 287, С. 127612 - 127612

Опубликована: Янв. 28, 2025

Язык: Английский

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A Dual-Mode Sensing System Based on Carbon Dots and Mno2 Nanosheets with Peroxidase-Like Activity for the Detection of Alkaline Phosphatase and its Inhibitors

Опубликована: Янв. 1, 2025

Язык: Английский

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A Dual-Mode Sensing System Based on Carbon Dots and Mno2 Nanosheets with Peroxidase-Like Activity for the Detection of Alkaline Phosphatase and its Inhibitors

Опубликована: Янв. 1, 2025

Язык: Английский

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