Macromolecules, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Язык: Английский
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(5)
Опубликована: Май 1, 2024
Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives
Язык: Английский
Процитировано
11
Materials Today Bio, Год журнала: 2024, Номер 26, С. 101028 - 101028
Опубликована: Март 24, 2024
The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.
Язык: Английский
Процитировано
8
Phytomedicine, Год журнала: 2024, Номер 135, С. 155554 - 155554
Опубликована: Март 29, 2024
The long history of clinical experience in China have confirmed the effectiveness traditional Chinese medicine (TCM) treating prostate cancer (PCa). Until now, several bioactive compounds with anti-PCa potential, such as curcumin, gallic acid, and quercetin, been extracted from TCM. Recent studies shown that encapsulating these TCM into nano-delivery system enhanced their bioavailability improved ability to target PCa tumors.
Язык: Английский
Процитировано
8
ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 16(1), С. 1605 - 1615
Опубликована: Дек. 27, 2023
An environmentally friendly smart ink was developed by incorporating fluorescein into functionalized poly(methyl methacrylate) (PMMA) nanoparticles synthesized using an emulsifier-free emulsion copolymerization approach. The functional comonomers of 2-(dimethylamino)ethyl methacrylate (DMAEMA), acrylamide, hydroxyethyl methacrylate, and glycidyl in 10 wt % with respect to methyl were used obtain the colloidal PMMA nanoparticles. Functional groups latex characterized Fourier-transform infrared spectroscopy. Field emission scanning electron microscopy results showed that all have nearly spherical morphologies variations size surface smoothness due presence different comonomers. Ultraviolet–visible fluorescence spectra indicated fluorescein-doped containing DMAEMA comonomer had highest absorbance intensity. In alkaline media, turns a dianion, showing red shift increased UV–vis addition, inductive characteristics tertiary amine result enhancing conjugation molecules increasing intensities. Therefore, formulation applications securing documents fingerprints, encrypting banknotes money, detecting latent crafting anticounterfeiting paper, eventually providing optical detection indication scratches.
Язык: Английский
Процитировано
18
Advanced Functional Materials, Год журнала: 2023, Номер 33(51)
Опубликована: Сен. 8, 2023
Abstract Aggregate materials have attracted tremendous attention because of their modified or totally different properties compared with molecular counterparts. Among various mesoscopic aggregate materials, polymeric micromaterials possess the advantages diverse structures and flexible manufacturing, enabling them to serve as excellent carriers for aggregation‐induced emission luminogens (AIEgens) good platforms research science. In recent years, constructed from AIEgens witnessed rapid development show great application potential in fields, such environmental sensing, multicolor displaying, energy conversion. This review summarizes progress on design, preparation, structure, applications AIEgen‐based micromaterials. According structure features, are divided into three categories, including microsphere, microfiber, other‐shaped microparticles. The most representative examples each category highlighted by focusing subdivision solid porous microcapsule, microfiber doped‐ coated AIEgens, core–shell microfiber. Finally, challenges prospects this field also discussed. It is hoped that can provide readers an overall view boost further research.
Язык: Английский
Процитировано
17
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(32)
Опубликована: Май 14, 2024
Abstract Nanostructuration of dynamic helical polymers such as poly(phenylacetylene)s (PPAs) depends on the secondary structure adopted by polymer and functional group used to connect chiral pendant PPA backbone. Thus, while PPAs with flexible scaffolds ( para ‐ meta ‐substituted, ω 1 <165°) generate nanoprecipitation low polydisperse nanospheres controllable size at different acetone/water mixtures, those a quasi‐static behavior presence an extended, almost planar ortho‐ substituted, >165°), aggregate into mixture spherical oval nanostructures whose is not controlled. Photostability studies show that poly(phenylacetylene) particles are more stable light irradiation than when dissolved macromolecularly. Moreover, photostability particle its screw sense excess. This fact, in combination encapsulation ability these particles, allows creation stimuli‐responsive nanocarriers, cargo can be delivered irradiation.
Язык: Английский
Процитировано
5
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер unknown
Опубликована: Ноя. 30, 2023
Increasing the security by multilevel authentication mechanism was most significant challenge in recent years for development of anticounterfeiting inks based on photoluminescent nanomaterials. For this purpose, greatest strategy is use multicomponent organic materials and a combination Förster resonance energy transfer (FRET) with intelligent behavior photochromic compounds like spiropyran. Here, hydroxyl-functionalized polymer nanoparticles were synthesized emulsion copolymerization methyl methacrylate (MMA) 2-hydroxyethyl (HEMA) different compositions (0-30 wt % HEMA). Results illustrated that size changed from 64 to 204 nm, morphology evolution spherical Janus shape observed increasing concentration HEMA. Photoluminescent red, green, blue (RGB) fluorescence emissions prepared modification containing 15 HEMA spiropyran, fluorescein, coumarin, respectively. To develop dual-color multicolor display static dynamic emission, RGB latex samples mixed together ratios printed cellulosic paper. emission developed can be photoswitched between statuses, including white blue, green red/orange, purple pink, utilizing FRET phenomenon, photochromism, both phenomena. Samples spiropyran displayed color changes orange, pink depending composition. Hence, used printing tags also painting some hand-drawn artworks, which obtained results indicating high printability, maximum intensity, resolution, fast responsivity upon UV-light irradiations 254 nm (for mode) 365 mode). In addition, under irradiation change observed, resulting inks. Actually, are efficient candidates developing new category chameleon-like high-security have tunable optical properties complex mechanisms.
Язык: Английский
Процитировано
11
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 303 - 359
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Precision medicine and engineering., Год журнала: 2025, Номер unknown, С. 100019 - 100019
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0