Nanomaterials,
Год журнала:
2023,
Номер
14(1), С. 67 - 67
Опубликована: Дек. 26, 2023
Liver-targeting
nanoparticles
have
emerged
as
a
promising
platform
for
the
induction
of
immune
tolerance
by
taking
advantage
liver’s
unique
tolerogenic
properties
and
nanoparticles’
physicochemical
flexibility.
Such
an
approach
provides
versatile
solution
to
treatment
diversity
immunologic
diseases.
In
this
review,
we
begin
assessing
design
parameters
integral
cell-specific
targeting
nanoplatforms
engineered
target
four
critical
immunogenic
hepatic
cells,
including
liver
sinusoidal
epithelial
cells
(LSECs),
Kupffer
(KCs),
stellate
(HSCs),
hepatocytes.
We
also
include
overview
multiple
therapeutic
strategies
in
which
are
being
studied
treat
many
allergies
autoimmune
disorders.
Finally,
explore
challenges
using
field
while
highlighting
future
avenues
expand
utility
liver-targeting
processes.
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
This
review
describes
the
formation
of
a
protein
corona
(or
its
absence)
on
different
classes
nanoparticles,
basic
principles,
and
consequences
for
nanomedicine.
For
this
purpose,
it
general
concepts
to
control
(guide/minimize)
interaction
between
artificial
nanoparticles
plasma
proteins
reduce
formation.
Thereafter,
methods
qualitative
or
quantitative
determination
are
presented,
as
well
properties
nanoparticle
surfaces,
which
relevant
prevention
formation).
Thereby
especially
role
grafting
density
hydrophilic
polymers
surface
is
discussed
prevent
corona.
In
context
also
potential
detergents
(surfactants)
temporary
modification
grafting-to
grafting-from
approaches
permanent
discussed.
The
concludes
by
highlighting
several
promising
avenues.
includes
(i)
use
without
active
targeting,
(ii)
synthetic
address
immune
system,
(iii)
recollection
with
defined
after
in
vivo
application
sample
blood
proteome
(iv)
further
Experimental Hematology and Oncology,
Год журнала:
2025,
Номер
14(1)
Опубликована: Янв. 31, 2025
Liposomes
and
lipid
nanoparticles
are
common
lipid-based
drug
delivery
systems
play
important
roles
in
cancer
treatment
vaccine
manufacture.
Although
significant
progress
has
been
made
with
these
nanocarriers
recent
years,
efficient
clinical
translation
of
active
targeted
liposomal
remains
extremely
challenging.
In
this
review,
we
focus
on
liposomes,
stimuli-responsive
strategy
combined
therapy
treatment.
We
also
summarize
advances
liposome
nanoparticle
applications
nucleic
acid
tumor
vaccination.
addition,
discuss
limitations
challenges
the
nanomaterials
make
recommendations
for
future
research
therapy.
ACS Nano,
Год журнала:
2023,
Номер
17(13), С. 12458 - 12470
Опубликована: Июнь 28, 2023
The
therapeutic
efficacy
and
adverse
impacts
of
nanoparticles
(NPs)
are
strongly
dependent
on
their
systemic
circulation
time.
corona
proteins
adsorbed
the
NPs
determine
plasma
half-lives,
hence,
it
is
crucial
to
identify
shortening
or
extending
In
this
work,
in
vivo
time
composition
superparamagnetic
iron
oxide
(SPIONs)
with
different
surface
charges/chemistries
were
analyzed
over
SPIONs
neutral
positive
charges
showed
longest
shortest
times,
respectively.
most
striking
observation
was
that
corona-coated
similar
opsonin/dysopsonin
content
implying
these
biomolecules
not
only
contributing
factors.
Long-circulating
adsorb
higher
concentrations
osteopontin,
lipoprotein
lipase,
coagulation
factor
VII,
matrix
Gla
protein,
secreted
phosphoprotein
24,
alpha-2-HS-glycoprotein,
apolipoprotein
C-I,
while
short-circulating
amounts
hemoglobin.
Therefore,
may
be
considered
determining
factors
governing
NP
Advanced Drug Delivery Reviews,
Год журнала:
2023,
Номер
199, С. 114965 - 114965
Опубликована: Июнь 13, 2023
The
delivery
of
cures
for
retinal
diseases
remains
problematic.
There
are
four
main
challenges:
passing
through
multiple
barriers
the
eye,
to
particular
cell
types,
capability
carry
different
forms
therapeutic
cargo
and
long-term
efficacy.
Lipid-based
nanoparticles
(LBNPs)
potent
overcome
these
challenges
due
their
unique
merits:
amphiphilic
nanoarchitectures
pass
biological
barriers,
vary
modifications
with
specific
affinity
target
flexible
capacity
large
mixed
types
cargos
slow-release
formulations
treatment.
We
have
reviewed
latest
research
on
applications
LBNPs
treating
categorized
them
by
payloads.
Furthermore,
we
identified
technical
discussed
possible
future
development
expand
potential
in
diseases.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 6, 2024
Abstract
Protein
corona,
a
layer
of
biomolecules
primarily
comprising
proteins,
forms
dynamically
on
nanoparticles
in
biological
fluids
and
is
crucial
for
predicting
nanomedicine
safety
efficacy.
The
protein
composition
the
corona
typically
analyzed
using
liquid
chromatography-mass
spectrometry
(LC-MS/MS).
Our
recent
study,
involving
identical
samples
by
17
proteomics
facilities,
highlighted
significant
data
variability,
with
only
1.8%
proteins
consistently
identified
across
these
centers.
Here,
we
implement
an
aggregated
database
search
unifying
parameters
such
as
variable
modifications,
enzyme
specificity,
number
allowed
missed
cleavages
stringent
1%
false
discovery
rate
at
peptide
levels.
Such
uniform
dramatically
harmonizes
data,
increasing
reproducibility
percentage
consistency-identified
unique
distinct
cores.
Specifically,
out
717
quantified
253
(35.3%)
are
shared
among
top
5
facilities
(and
16.2%
11
facilities).
Furthermore,
note
that
reduction
alkylation
important
steps
sample
processing
expected,
omitting
reduces
total
peptides
around
20%.
These
findings
underscore
need
standardized
procedures
analysis,
which
vital
advancing
clinical
applications
nanoscale
biotechnologies.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(13), С. 5646 - 5669
Опубликована: Март 22, 2024
Nanodelivery
vehicles
(NDVs)
are
engineered
nanomaterials
(ENMs)
that,
within
the
agricultural
sector,
have
been
investigated
for
their
ability
to
improve
uptake
and
translocation
of
agrochemicals,
control
release,
or
target
specific
tissues
subcellular
compartments.
Both
inorganic
organic
NDVs
studied
agrochemical
delivery
in
literature,
but
research
on
latter
has
slower
develop
than
literature
former.
Since
two
classes
exhibit
significant
differences
surface
chemistry,
physical
deformability,
even
colloidal
stability,
trends
that
apply
may
not
hold
NDVs,
vice
versa.
We
here
review
current
uptake,
translocation,
biotransformation,
cellular
internalization
plants
following
foliar
root
administration.
A
background
plant
physiology
is
provided
as
a
leveling
ground
researchers
field.
Trends
examined
function
NDV
properties
compared
those
reported
nanomaterials.
Methods
assessing
fate
transport
(a
major
bottleneck
field)
discussed.
end
by
identifying
knowledge
gaps
must
be
understood
order
rationally
design
precision
nanodelivery.
DNA
nanotechnology
has
emerged
as
a
powerful
approach
to
engineering
biophysical
tools,
therapeutics,
and
diagnostics
because
it
enables
the
construction
of
designer
nanoscale
structures
with
high
programmability.
Based
on
base
pairing
rules,
nanostructure
size,
shape,
surface
functionality,
structural
reconfiguration
can
be
programmed
degree
spatial,
temporal,
energetic
precision
that
is
difficult
achieve
other
methods.
However,
properties
structure
constructs
are
greatly
altered
in
vivo
due
spontaneous
protein
adsorption
from
biofluids.
These
adsorbed
proteins,
referred
corona,
remain
challenging
control
or
predict,
subsequently,
their
functionality
fate
engineer.
To
address
these
challenges,
we
prepared
library
diverse
nanostructures
investigated
relationship
between
design
features
composition
corona.
We
identified
characteristics
important
for
developed
machine-learning
model
predicts
which
proteins
will
enriched
based
structures'
properties.
Our
work
help
understand
program
function
biomedical
applications.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Neuronanomedicine
harnesses
nanoparticle
technology
for
the
treatment
of
neurological
disorders.
An
unavoidable
consequence
delivery
to
biological
systems
is
formation
a
protein
corona
on
surface.
Despite
well-established
influence
behavior
and
fate,
as
well
FDA
approval
neuro-targeted
nanotherapeutics,
effect
physiologically
relevant
nanoparticle-brain
cell
interactions
insufficiently
explored.
Indeed,
less
than
1%
studies
have
investigated
coronas
formed
in
cerebrospinal
fluid
(CSF),
surrounding
brain.
Herein,
we
utilize
two
clinically
polymeric
nanoparticles
(PLGA
PLGA-PEG)
evaluate
serum
CSF
coronas.
LC-MS
analysis
revealed
distinct
compositions,
with
selective
enrichment/depletion
profiles.
Enhanced
association
precoated
particles
brain
cells
demonstrates
importance
selecting
fluids
more
accurately
study
subsequent
nanoparticle-cell
interactions,
paving
way
improved
engineering
vivo
applications.
