eXPRESS Polymer Letters,
Год журнала:
2023,
Номер
18(2), С. 160 - 192
Опубликована: Дек. 6, 2023
Polymer-based
hydrogels
are
hydrophilic
polymer
networks
with
a
remarkable
capacity
to
absorb
substantial
amounts
of
water
and
biological
fluids,
rendering
them
highly
attractive
for
drug
delivery
applications.The
COVID-19
pandemic
has
acted
as
catalyst
research
innovation
in
the
realm
polymer-based
delivery,
particular
emphasis
on
antiviral
therapeutics,
vaccines,
diagnostics,
precision
respiratory
system.The
distinctive
attributes
hydrogels,
such
their
biocompatibility,
customizable
release
profiles,
ease
functionalization,
establish
versatile
platforms
development
advanced
systems
combat
not
only
but
also
spectrum
other
infectious
diseases.This
study
is
dedicated
scruti-nizing
evaluating
characteristics
employed
treatment
diseases
associated
SARS-CoV-2
virus.Furthermore,
investigation
introduces
novel
classification
system
deployed
SARS-CoV-2-related
diseases.Additionally,
paper
provides
an
up-to-date
evaluation
latest
developed
utilized
dis-eases
linked
virus,
based
conducted
through
recent
months
2023.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(5), С. 5272 - 5286
Опубликована: Фев. 21, 2024
Superparamagnetic
nanoparticle-arrested
hydrogel
matrices
have
immense
significance
in
smart
soft
biomaterials.
Herein,
we
report
the
synthesis
of
superparamagnetic
nanoparticle-loaded
magneto-responsive
tough
elastomeric
hydrogels
for
dual-responsive
drug
delivery.
In
first
phase
work,
carried
out
room-temperature
amine-functionalized
iron
oxide
nanoparticles
(IONPs),
and
second
demonstrated
that
IONPs
could
act
as
a
toughening
agent
well
viscosity
modifier
poly(acrylic
acid-co-hydroxyethyl
methacrylate)
copolymer
hydrogels.
The
was
tested
by
Fourier
transformed
infrared
(FTIR)
spectroscopy,
X-ray
photoelectron
spectroscopy
(XPS),
continuous-wave-electron
paramagnetic
resonance
(CW-EPR).
Moreover,
affect
its
gelation
time
elasticity
significantly,
which
also
evaluated
from
rheological
behavior.
compressive
mechanical
strength
(∼120
kPa),
elasticity,
recovery
to
original
shape
(zero
permanent
set),
water
uptake,
thixotropic
behavior
under
dynamic
stress
hybrid
supported
robustness
swelled
state.
release
showed
dual
parameter
dependency
(IONPs
cross-linker)
responsiveness
against
both
pH
static
magnetic
field.
delayed
network
rupturing,
delivery
nature,
noncytotoxic
human
live
cells
promote
this
an
ideal
alternative
remotely
controlled
vehicle.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Апрель 10, 2024
Cancer
is
a
severe
disease
that
results
in
death
all
countries
of
the
world.
A
nano-based
drug
delivery
approach
best
alternative,
directly
targeting
cancer
tumor
cells
with
improved
cellular
uptake.
Different
types
nanoparticle-based
carriers
are
advanced
for
treatment
cancer,
and
to
increase
therapeutic
effectiveness
safety
therapy,
many
substances
have
been
looked
into
as
carriers.
Lipid-based
nanoparticles
(LBNPs)
significantly
attracted
interest
recently.
These
natural
biomolecules
alternate
other
polymers
frequently
recycled
medicine
due
their
amphipathic
properties.
Lipid
typically
provide
variety
benefits,
including
biocompatibility
biodegradability.
This
review
covers
different
classes
LBNPs,
characterization
synthesis
technologies.
discusses
most
significant
advancements
lipid
nanoparticle
technology
use
administration.
Moreover,
also
emphasized
applications
used
types.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(17)
Опубликована: Фев. 26, 2024
As
an
indispensable
part
of
the
human
sensory
system,
visual
acuity
may
be
impaired
and
even
develop
into
irreversible
blindness
due
to
various
ocular
pathologies.
Among
diseases,
fundus
neovascularization
diseases
(FNDs)
are
prominent
etiologies
impairment
worldwide.
Intravitreal
injection
anti-vascular
endothelial
growth
factor
drugs
remains
primary
therapy
but
is
hurdled
by
common
complications
incomplete
potency.
To
renovate
current
therapeutic
modalities,
nanomedicine
emerged
as
times
required,
which
endowed
with
advanced
capabilities,
able
fulfill
effective
drug
delivery
achieve
precise
release
control,
thus
further
improving
effect.
This
review
provides
a
comprehensive
summary
advances
in
for
FND
management
from
state-of-the-art
studies.
First,
modalities
FNDs
thoroughly
introduced,
focusing
on
key
challenges
delivery.
Second,
nanocarriers
comprehensively
reviewed
posterior
based
nanostructures:
polymer-based
nanocarriers,
lipid-based
inorganic
nanoparticles.
Thirdly,
characteristics
microenvironment,
their
pathological
changes
during
FNDs,
corresponding
strategies
constructing
smart
elaborated.
Furthermore,
prospects
discussed.
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(2), С. 9 - 9
Опубликована: Март 23, 2025
Antibiotic
resistance
poses
a
significant
global
health
challenge,
undermining
the
effectiveness
of
conventional
treatments
and
increasing
mortality
rates
worldwide.
Factors
such
as
overuse
misuse
antibiotics
in
healthcare
agriculture,
along
with
poor
infection
control
practices,
have
accelerated
emergence
resistant
bacterial
strains.
The
stagnation
development
new
antibiotics,
compounded
by
economic
biological
challenges,
has
necessitated
alternative
approaches
to
combat
infections.
Nanotechnology
provides
promising
solution
using
nanoparticles
(NPs),
which
bacteria
through
mechanisms
like
membrane
disruption
reactive
oxygen
species
(ROS)
generation.
Metal-based
silver
zinc
oxide
possess
intrinsic
antimicrobial
properties,
while
polymer-
carbon-based
enhance
drug
delivery
biofilm
penetration.
Unlike
operate
multi-mechanistic
pathways,
reducing
likelihood
improving
treatment
efficacy.
This
review
aims
provide
an
updated,
in-depth
look
at
recent
advances
nanoparticle
research
targeting
antibiotic
resistance,
discussing
different
types
nanoparticles,
action,
current
challenges
opportunities.
By
exploring
evolving
role
nanotechnology
addressing
this
crisis,
intends
highlight
potential
for
transform
landscape
infections
inspire
further
into
these
innovative
solutions.
Abstract
Lipid
nanoparticles
(LNPs)
have
emerged
as
a
transformative
platform
for
the
targeted
delivery
of
therapeutic
agents,
revolutionizing
treatment
paradigms
across
spectrum
diseases.
Since
inception
liposomes
in
1960s,
lipid‐based
nanotechnology
has
evolved
to
address
limitations
such
poor
bioavailability,
off‐target
effects,
and
instability,
thereby
enhancing
efficacy
safety
drug
administration.
This
review
highlights
latest
advancements
LNPs
technology,
focusing
on
their
application
cancer
therapy,
gene
infectious
disease
management,
glaucoma,
other
clinical
areas.
Recent
studies
underscore
potential
deliver
messenger
RNA
(mRNA)
small
interfering
(siRNA)
precise
genetic
intervention,
exemplified
by
breakthroughs
interference
CRISPR‐Cas9
genome
editing.
Additionally,
been
successfully
employed
ameliorate
conditions,
demonstrating
versatility
addressing
both
acute
chronic
disorders.
However,
challenges
persist
concerning
large‐scale
manufacturing,
long‐term
stability,
comprehensive
evaluations.
Future
research
must
focus
optimizing
formulations,
exploring
synergistic
combinations
with
existing
therapies,
expanding
scope
treatable
The
integration
into
personalized
medicine
exploration
applications
diseases
represent
promising
avenues
further
investigation.
are
poised
play
an
increasingly
central
role
development
next‐generation
therapeutics.
Lipid-based
Nanoparticles
(LBNPs)
have
emerged
as
a
transformative
approach
in
cancer
treatment,
offering
innovative
drug
delivery
solutions
that
enhance
therapeutic
efficacy
while
minimizing
adverse
effects.
By
exploring
the
characterization,
classification,
synthesis,
targeting
strategies,
and
advantages
of
LBNPs,
this
study
highlights
how
LBNPs
been
used
to
overcome
limitations
traditional
chemotherapy
improve
patient
outcomes.
As
nanotechnology
revolutionizes
therapy,
emergence
promising
strategy
for
targeted
has
led
optimism
regarding
future
treatment.
This
review
extensively
assesses
structure,
categories,
production
methods,
benefits,
recent
advancements
treating
cancer.
It
also
current
challenges
possible
directions.
is
aimed
at
providing
comprehensive
understanding
LBNPs’
potential
therapy.
Liposomes,
nanostructured
lipid
carriers,
solid
nanoparticles,
lipid-polymer
hybrid
nanoparticles
are
all
types
each
with
unique
features
interest
These
particles
can
be
synthesized
through
various
procedures,
such
bulk
nanoprecipitation,
solvent-based
emulsification,
or
microfluidics.
Passive
systems,
active
responsive
platforms
direct
tumors.
Consequently,
provide
an
improved
release
pattern
minimizes
side
effects
enhancing
efficacy.
With
combination
offer
hopeful
Continued
research
expected
outcomes
overall
quality
life
care.
Abstract
mRNA
therapeutics
have
significantly
evolved
within
the
life
sciences,
particularly
in
applications
such
as
vaccines,
tumor
immunotherapy,
protein
replacement,
gene
editing,
and
monoclonal
antibody
therapy.
To
fully
realize
potential
of
drugs
mitigate
adverse
effects,
substantial
vector
materials
been
developed
for
delivery
these
pharmaceutical
agents.
Lipid
nanoparticles
(LNPs)
represent
most
clinically
advanced
carriers,
recognized
by
U.S.
Food
Drug
Administration
approved
vaccines
numerous
clinical
trials.
Diverse
therapeutic
necessitate
tailored
design
LNPs.
Herein,
we
outline
principles
LNP
delivery,
focusing
specifically
on
their
effectiveness,
targeting
capabilities,
safety
profiles,
nanoparticle
stability.
Additionally,
present
latest
advancements
mRNA‐LNP
technology.
This
review
aims
to
elucidate
benefits
systems
therapeutics,
providing
insights
into
breakthroughs
innovative
ideas
further
enhancing
advantages.
These
summaries
are
dedicated
promoting
broader
LNP‐mRNA
drugs,
aiming
advance
treatment
serious
diseases
an
effective
safe
manner.
