ACS Applied Polymer Materials, Год журнала: 2024, Номер 6(19), С. 12059 - 12070
Опубликована: Сен. 19, 2024
Язык: Английский
Nano TransMed, Год журнала: 2024, Номер 3, С. 100030 - 100030
Опубликована: Янв. 6, 2024
Delayed wound healing brings additional physical, mental, and financial burdens. Microneedles (MNs) are a novel dressing form can incorporate drug delivery systems. Quercetin is known for its remarkable antioxidant capacity may have distinctive effect on healing. We designed constructed gelatin methacryloyl (GelMa) MNs carrying (Q-MNs). In vitro, the physical properties, cell safety, migration, angiogenesis, collagen formation, oxidative stress levels, were performed to characterize Q-MNs. vivo, full-thickness skin models established evaluate re-epithelialization impact of control, MN, Q-MN groups. The Q-MNs mechanically strong enough penetrate sustained possessed good biocompatibility. Moreover, evidently facilitated both in vitro promoted formation neo-angiogenesis, reduction levels. could motivate with enhanced vascularization decreased thus providing feasible strategy
Язык: Английский
Процитировано
23
APL Materials, Год журнала: 2025, Номер 13(1)
Опубликована: Янв. 1, 2025
Wound healing is a complex, variable, and time-dynamic repair process. Wounds can be classified as acute wounds or chronic wounds, effective wound management still major challenge in clinical nursing settings. The microenvironment collectively regulated by internal biomolecules, external drugs, sanitation. Traditional dressings (powders, bandages, sponges, etc.) often have poor therapeutic effects during processes because they cannot respond to the dynamic changes over long-term. Stimulus-responsive biomaterials, which are activated various factors intrinsic influences, hold great promise for precise drug delivery controlled release. Various stimulus-responsive hydrogels been developed recent years, exhibiting range of “smart” properties, such interacting with wound, sensing conditions environmental changes, responding accordingly, thereby effectively promoting healing. This review discusses latest advancements used We introduce design scheme stimulus-response detail based on local biological/biochemical peculiarities (pH, reactive oxygen species glucose, enzymes, physical microenvironments (temperature, light, ultrasound, electric fields, etc.). Furthermore, we explore several promising tissue-engineered constructs (nanofibers, scaffolds, microneedles, microspheres). Finally, summarize basis active research challenges, current progress, development trends field.
Язык: Английский
Процитировано
3
Small, Год журнала: 2024, Номер 20(45)
Опубликована: Июль 28, 2024
Several natural Chinese herbal medicines have demonstrated considerable potential in facilitating wound healing, while the primary concern remains centered around optimizing formulation and structure to maximize their efficacy. To address this, a microneedles drug delivery system is proposed that harnesses gelatinized starch key ingredients-aloe vera berberine. After aged well-designed mold, starch-based are fabricated with suitable mechanical strength load components. The resulting hydrogel microneedles, enriched integrated berberine aloe, exhibit antibacterial, anti-inflammatory, fibroblast growth-promoting properties, thereby healing whole process. In vivo experimental results underscore notable achievements of early-stage antibacterial effects subsequent tissue reconstruction, contributing significantly overall These emphasize advantageous combination traditional medicine presenting novel strategy for repair opening new avenues application medicine.
Язык: Английский
Процитировано
11
International Journal of Pharmaceutics X, Год журнала: 2025, Номер 9, С. 100317 - 100317
Опубликована: Фев. 10, 2025
The conventional oral administration of pioglitazone for Type II diabetes management is frequently compromised by hepatic first-pass metabolism and associated systemic adverse effects, necessitating the development enhanced transdermal delivery approaches. This study developed a drug system combining conductive hydrogel microneedles iontophoresis to improve hydrochloride (PIO) its therapeutic efficacy in treatment type diabetes. microneedles, fabricated using poly(methyl vinyl ether-alt-maleic anhydride) as main matrix material, exhibited excellent conductivity, mechanical strength, high loading capacity. In vitro permeation experiments demonstrated that, when combined with at current intensity 0.5 mA, cumulative PIO reached 238.1 ± 27.14 μg/cm2 within 48 h, significantly higher than that microneedle group alone. diabetic rat model, microneedle-iontophoresis displayed better hypoglycemic effect group, blood glucose reduction 6.3 mmol/L on day 8, 5.1 positive control group. Pharmacokinetic analysis indicated Tmax, T1/2, mean residence time were longer those administration, indicating sustained-release characteristics. Skin irritation tests revealed caused only mild, transient skin irritation, complete recovery 24 h. conclusion, can effectively enhance delivery, bioavailability, while also exhibiting good safety potential clinical application value.
Язык: Английский
Процитировано
1
Gels, Год журнала: 2025, Номер 11(3), С. 206 - 206
Опубликована: Март 15, 2025
Hydrogel microneedles (HMNs) have emerged as a transformative platform for minimally invasive drug delivery and biosensing, offering enhanced bioavailability, controlled release, real-time biomarker detection. By leveraging swelling hydrogels, nanomaterial integration, stimuli-responsive properties, HMNs provide precision medicine capabilities across diverse therapeutic diagnostic applications. However, challenges remain in mechanical stability, hydrogel-based MNs must balance flexibility with sufficient strength skin penetration. Drug retention release require optimization to prevent premature diffusion ensure sustained effects. Additionally, biosensing accuracy is influenced by variability interstitial fluid extraction signal transduction. Clinical translation hindered regulatory hurdles, scalability concerns, the need extensive safety validation human trials. This review critically examines key materials, fabrication techniques, functional testing frameworks of while addressing these limitations. Furthermore, we explore future research directions smart wearable MNs, AI-assisted hybrid drug–device platforms optimize transdermal medicine. Overcoming barriers will drive clinical adoption HMNs, paving way next-generation patient-centered therapeutics diagnostics.
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(10), С. 12202 - 12216
Опубликована: Фев. 28, 2024
As for wound drug delivery, microneedles (MNs) have attracted wide attention. However, while effective at increasing the depth of traditional MNs often limited loads and difficulty penetrating scabs on wounds. Herein, we develop a delivery system combining MgO@polydopamine (MgO@PDA) nanoparticle-loaded photothermal MN patches chitosan (CS) gel to inhibit formation deliver sufficient drugs into deep tissue. When inserted wound, can keep bed moist weakly acidic accelerate closure. The released MgO@PDA nanoparticles from both tips backing layer, which immensely increase load, continuously release Mg2+ in moist, bed, promoting tissue migration microvessels. show excellent antibacterial activity under near-infrared irradiation synergized with CS gel, PDA coating also overcome adverse effects oxidative stress. Through vitro vivo experiments, showed remarkable antibacterial, antioxidant, anti-inflammatory, pro-angiogenic effects, indicating its potential treatment infectious
Язык: Английский
Процитировано
7
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 4771 - 4790
Опубликована: Июль 10, 2024
Microneedles are a novel drug delivery system that offers advantages such as safety, painlessness, minimally invasive administration, simplicity of use, and controllable delivery. As type polymer microneedle with three-dimensional network structure, hydrogel microneedles (HMNs) possess excellent biocompatibility biodegradability encapsulate various therapeutic drugs while maintaining activity, thus attracting significant attention. Recently, they have been widely employed to promote wound healing demonstrated favorable effects. Although there reviews about HMNs, few them focus on management. Herein, we present comprehensive overview the design preparation methods particular emphasis their application status in healing, including acute infected diabetic scarless healing. Finally, examine limitations HMNs management provide suggestions for future research directions.
Язык: Английский
Процитировано
5
Small Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 21, 2024
Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug while complemented with noninvasiveness patient compliance. Currently, the topical application of antimicrobials restricts drugs to critical areas wound bed, largely due barriers posed by necrotic tissue, scab formation, bacterial biofilms, which severely diminish bioavailability therapeutics. MNs enabled efficient targeted overcome many chronic challenges. Over past decade, significant progress has been made develop unique properties tailored for vaccines, anticancer, antimicrobials. As ongoing research continues refine MN design, material properties, formulations, potential revolutionizing efficacy, experience, therapeutic outcomes remains at forefront scientific research. In this review, insights are provided into latest progress, current developments, diverse applications delivery. Herein, translational is highlighted perspective on challenges associated clinical translation provided. Furthermore, review aids in identifying gaps empowering contributing future implementation cutting‐edge systems effectively tackle resistance.
Язык: Английский
Процитировано
5
Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 791 - 791
Опубликована: Июнь 16, 2024
This manuscript explores the transformative potential of swellable microneedles (MNs) in drug delivery and diagnostics, addressing critical needs medical treatment monitoring. Innovations hydrogel-integrated MN arrays facilitate controlled release, thereby expanding options for chronic diseases conditions that require precise dosage control. The review covers challenges, such as scalability, patient compliance, manufacturing processes, well achievements advanced manufacturing, biocompatibility, versatile applications. Nonetheless, limitations physiological responsiveness long-term stability remain, necessitating further research material innovation integration with digital technologies. Future directions focus on biomedical applications, advancements, regulatory considerations widespread clinical adoption.
Язык: Английский
Процитировано
4
ACS Nano, Год журнала: 2024, Номер 18(35), С. 23876 - 23893
Опубликована: Авг. 23, 2024
Fully integrated theranostic devices are highly esteemed in clinical applications, offering immense potential real-time disease monitoring and personalized care. Microneedles (MNs), as innovative wearable devices, boast important advantages biosensing therapy, thus holding significant promise the advancement of diagnostic therapeutic platforms. Encouragingly, advancements electrochemical sensing technology, micronano fabrication, biocompatible materials propelling momentum for MNs-based closed-loop systems, enhancing detection capabilities, biocompatibility, cost-effectiveness. Moreover, notable progress integrating MN chips with other biochips signifies a frontier growth. Successful trials target molecule drug delivery domains herald excellent translational prospects aforementioned platform. Finally, we delineate both challenges opportunities development including continuous monitoring, intelligent control algorithms, safety, regulatory considerations.
Язык: Английский
Процитировано
4