Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Designing drugs to intelligently respond different ratio of biological electron donors/receptors in cancer cells and normal is a promising strategy achieve highly effective less toxic chemotherapy. Herein by employing metal center active the selenium‐containing electrophilic drug Ru(phtpy‐NO 2 )(phenSe)Cl ( RuSe ) with strongly polarization characteristics are synthesized which can efficiently shuttle electrons from donors convert oxidative stress. The rate transfer at selenium 1.81 times higher cell environments compared environments. This results being 14.98 more lethal than cells. Experimental demonstrate that transport process carried out via radicals intermediate positively correlated properties atoms. transports bioactive generate large number superoxide anions leading DNA damage decrease mitochondrial membrane potential further activates p53 signaling pathway amplifies cell‐killing effect after transporting electrons. work provides new avenue for design efficient chemotherapeutic agents.

Language: Английский

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Versatile Nanomaterials That Interfere with Ferroptosis in the Tumor Microenvironment

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2461 - 2473

Published: Feb. 1, 2025

Ferroptosis is a type of iron-dependent programmed cell death characterized by depletion glutathione. Although generally less harmful to normal cells, in tumor the high demand for iron ions provides conditions conducive ferroptosis. In this review, we provide an overview recent progress research on regulation ferroptosis summarizing and assessing current state, trends, applications nanomaterials cells. Given advantages terms targeting, safety, improved drug efficacy, reduced side effects, these materials are considered have potential therapeutic value modulating cells via different mechanisms. respect, describe methods modifying interfering with glutathione activity lipid peroxidation. The development that can be applied induce or inhibit anticipated new options treatment diverse range diseases.

Language: Английский

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Applications and Prospects of Micro/nanoelectrodes in Single-cell Imaging and Electrochemical Detection

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118161 - 118161

Published: Jan. 1, 2025

Language: Английский

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Glutathione: A Naturally-occurring Tripeptide for Functional Metal Nanomaterials

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Glutathione's role in synthesizing functional metal nanomaterials with unique optical properties and nanobiomedical applications.

Language: Английский

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Tumor Microenvironment-Responsive Lipid Peroxidation Amplifier: Harnessing Ferroptosis Resistance to Devastate the Ferroptosis Defense System

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Amplification of lipid peroxidation with tumor specificity represents a new avenue to boost ferroptosis-mediated anticancer therapeutics but remains challenging. Herein, we proposed metal-phenolic-network (MPN)-coated nanohybrid as microenvironment-responsive amplifier, consisting reactive oxygen species generator MPN, glutathione (GSH) scavenger GSH-P, and peroxidase 4 (GPX4) mRNA gene silencing sequence. The protective MPN shell this amplifier can be specifically disintegrated by acidic adenosine triphosphate (ATP)-rich microenvironments induce oxidative stress through the dual disruption redox homeostasis (Fenton-catalytic accumulation GSH depletion). Furthermore, stress-induced upregulation ferroptosis resistance-related apurinic/apyrimidinic endonuclease 1 (APE1) is further ingeniously employed an amplification element prompt release (AP) site-embedded GPX4 sequence which downregulate level. Based on tandem depletion substrate GPX4, defense system GPX4/GSH heavily devastated enable for effectively improving efficiency. We expect strategy expanded other important regulatory proteins provide mechanism study therapy.

Language: Английский

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Homogeneous electrochemiluminescence sensor based on novel Ru-MOF nanosheets for highly sensitive and efficient detection of glutathione without immobilization

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(5)

Published: April 12, 2025

Language: Английский

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Intelligent responsive nanogels: New Horizons in cancer therapy

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125050 - 125050

Published: Dec. 5, 2024

Language: Английский

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A CuS/Ag/Pt@ICG/DOX nanoplatform with cascaded nanozyme catalysis for tumor microenvironment remodeling and synergistic photodynamic/photothermal/chemodynamic therapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114743 - 114743

Published: April 1, 2025

Language: Английский

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Application of zeolitic imidazolate frameworks-8 in drug delivery and disease therapy: A review

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113835 - 113835

Published: Dec. 1, 2024

Language: Английский

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Atomic-level design of biomimetic iron–sulfur clusters for biocatalysis

Nanoscale, Journal Year: 2024, Volume and Issue: 16(40), P. 18644 - 18665

Published: Jan. 1, 2024

Schematic representation of the structural regulation strategy and progress Fe–S clusters.

Language: Английский

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