Membrane-Cloaked Nanodrug for Homologous Targeting and Treatment of Therapeutic Stress Escaped Cancer Stem Cells DOI
Weixiao Yan, Z. Li, Liang‐I Kang

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(22), С. 25900 - 25910

Опубликована: Ноя. 8, 2024

Cancer stem cells (CSCs) often exhibit high expression of the p38/MAPK signaling pathway during therapy, leading to therapeutic stress-induced cellular escape (TSCE) and presenting a significant barrier cancer treatment. Therefore, blocking stress CSCs or simultaneously targeting stress-escaping (TSCSCs) has become crucial strategy in therapy. However, lack specific markers for identifying TSCSCs greatly limited development effective treatments. cell membranes selective binding internalization by similar cells. Herein, we report nanoparticle with Fe3O4@SiO2 as core, which serves carrier load p38 inhibitor is subsequently coated homologous membranes. reported CSC membrane-coated nanoparticles that effectively targeted while minimizing off-target effects, inhibited TSCE tumor growth introducing thermotherapy. The application this nanomaterial holds promise overcoming current treatment challenges providing strategies Fluorescence colocalization vivo imaging demonstrate targets homogeneously effects. Transwell QPCR analyses show inhibits motility BCSCs preventing microtubule reorganization, thereby limiting their from TSCE. Additionally, inhibitor, was significantly through suppressing pathway.

Язык: Английский

Mannose-Modified Multifunctional Iron-Based Nanozyme for Hepatocellular Carcinoma Treatment by Remodeling the Tumor Microenvironment DOI
Qi Liu, Ziwei Liang, Jiapu Wang

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114548 - 114548

Опубликована: Фев. 3, 2025

Язык: Английский

Процитировано

2
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

и другие.

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2485 - 2529

Опубликована: Июнь 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Язык: Английский

Процитировано

9
Therapeutic Approaches with Iron Oxide Nanoparticles to Induce Ferroptosis and Overcome Radioresistance in Cancers DOI Creative Commons
Derek B. Sant’Angelo, Géraldine Descamps, Valentin Lecomte

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 325 - 325

Опубликована: Фев. 26, 2025

The emergence of nanotechnology in medicine, particularly using iron oxide nanoparticles (IONPs), may impact cancer treatment strategies. IONPs exhibit unique properties, such as superparamagnetism, biocompatibility, and ease surface modification, making them ideal candidates for imaging, therapeutic interventions. Their application targeted drug delivery, especially with traditional chemotherapeutic agents like cisplatin, has shown potential overcoming limitations low bioavailability systemic toxicity chemotherapies. Moreover, IONPs, by releasing ions, can induce ferroptosis, a form iron-dependent cell death, which offers promising pathway to reverse radio- chemoresistance therapy. In particular, demonstrate significant radiosensitisers, enhancing the effects radiotherapy promoting reactive oxygen species (ROS) generation, lipid peroxidation, modulating tumour microenvironment stimulate antitumour immune responses. This review explores multifunctional roles radiosensitisation through ferroptosis induction, highlighting their promise advancing head neck cancers. Additional research is crucial fully addressing clinical settings, offering novel approach personalised treatment.

Язык: Английский

Процитировано

1
Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets DOI Creative Commons
Guangpeng Gao, Xindi Zhang

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Язык: Английский

Процитировано

0
Nanozyme as tumor energy homeostasis disruptor mediated ferroptosis for high-efficiency radiotherapy DOI
Xingchen Li, Yuxuan Zhang,

Annan Liu

и другие.

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 688, С. 44 - 58

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

0
Clonogenic assay and computational modeling using real cell images to study physical enhancement and cellular sensitization induced by metal nanoparticles under MV and kV X-ray irradiation DOI Creative Commons

Rodrigo Hernández Millares,

Chaewon Bae,

Seokjin Kim

и другие.

Nanoscale, Год журнала: 2024, Номер 16(14), С. 7110 - 7122

Опубликована: Янв. 1, 2024

A study on the radiophysical dose enhancement and intrinsic biological sensitization by gold iron nanoparticles in A549 cancer cells.

Язык: Английский

Процитировано

2
Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects DOI Creative Commons

Yuanchun Chen,

Shijie Shangguan,

Zhongyu Lin

и другие.

BMEMat, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Abstract X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical tumor treatment through radiotherapy. Despite their widespread use, optimizing X‐ray efficacy remains critical challenge due to issues such as resistance damage surrounding health tissues. Recent advancements nanotechnology have introduced new opportunities challenges cancer diagnosis treatment. This review summarizes the latest progress nanomaterials for X‐ray‐triggered therapy, highlighting various advantages targeted delivery, reduced side effects, enhanced therapeutic efficacy. We examine how nanomaterials, including metals, metal oxides, sulfides, fluorides, rare earth cluster compounds, metal‐organic frameworks, nanohybrids, enhance effectiveness treatments. Furthermore, we address current future prospects efficient aiming provide comprehensive overview researchers clinicians field.

Язык: Английский

Процитировано

2
Inorganic Nanomedicine—Mediated Ferroptosis: A Synergistic Approach to Combined Cancer Therapies and Immunotherapy DOI Open Access
Adityanarayan Mohapatra, Ayeskanta Mohanty, In‐Kyu Park

и другие.

Cancers, Год журнала: 2024, Номер 16(18), С. 3210 - 3210

Опубликована: Сен. 20, 2024

Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has generated substantial interest in cancer therapy. Various methods have been developed to induce ferroptosis tumor cells, including approved drugs, experimental compounds, and nanomedicine formulations. Unlike apoptosis, presents unique molecular cellular features, representing promising approach for cancers resistant conventional treatments. Recent research indicates strong link between the immune microenvironment, suggesting potential trigger robust antitumor responses. Multiple metabolic pathways control ferroptosis, iron, lipid, redox metabolism. Thus, understanding interaction metabolism is crucial developing effective anticancer therapies. This review provides an in-depth discussion on combining inorganic nanoparticles with therapies such as phototherapy, chemotherapy, radiotherapy, immunotherapy, role these combination Furthermore, this paper explores future treatment using nanomedicine, focusing how can enhance cells boost immunity. The goal advance ferroptosis-based from laboratory clinical applications.

Язык: Английский

Процитировано

1
Membrane-Cloaked Nanodrug for Homologous Targeting and Treatment of Therapeutic Stress Escaped Cancer Stem Cells DOI
Weixiao Yan, Z. Li, Liang‐I Kang

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(22), С. 25900 - 25910

Опубликована: Ноя. 8, 2024

Cancer stem cells (CSCs) often exhibit high expression of the p38/MAPK signaling pathway during therapy, leading to therapeutic stress-induced cellular escape (TSCE) and presenting a significant barrier cancer treatment. Therefore, blocking stress CSCs or simultaneously targeting stress-escaping (TSCSCs) has become crucial strategy in therapy. However, lack specific markers for identifying TSCSCs greatly limited development effective treatments. cell membranes selective binding internalization by similar cells. Herein, we report nanoparticle with Fe3O4@SiO2 as core, which serves carrier load p38 inhibitor is subsequently coated homologous membranes. reported CSC membrane-coated nanoparticles that effectively targeted while minimizing off-target effects, inhibited TSCE tumor growth introducing thermotherapy. The application this nanomaterial holds promise overcoming current treatment challenges providing strategies Fluorescence colocalization vivo imaging demonstrate targets homogeneously effects. Transwell QPCR analyses show inhibits motility BCSCs preventing microtubule reorganization, thereby limiting their from TSCE. Additionally, inhibitor, was significantly through suppressing pathway.

Язык: Английский

Процитировано

0