Membrane-Cloaked Nanodrug for Homologous Targeting and Treatment of Therapeutic Stress Escaped Cancer Stem Cells DOI
Weixiao Yan, Z. Li, Liang‐I Kang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25900 - 25910

Published: Nov. 8, 2024

Cancer stem cells (CSCs) often exhibit high expression of the p38/MAPK signaling pathway during therapy, leading to therapeutic stress-induced cellular escape (TSCE) and presenting a significant barrier cancer treatment. Therefore, blocking stress CSCs or simultaneously targeting stress-escaping (TSCSCs) has become crucial strategy in therapy. However, lack specific markers for identifying TSCSCs greatly limited development effective treatments. cell membranes selective binding internalization by similar cells. Herein, we report nanoparticle with Fe3O4@SiO2 as core, which serves carrier load p38 inhibitor is subsequently coated homologous membranes. reported CSC membrane-coated nanoparticles that effectively targeted while minimizing off-target effects, inhibited TSCE tumor growth introducing thermotherapy. The application this nanomaterial holds promise overcoming current treatment challenges providing strategies Fluorescence colocalization vivo imaging demonstrate targets homogeneously effects. Transwell QPCR analyses show inhibits motility BCSCs preventing microtubule reorganization, thereby limiting their from TSCE. Additionally, inhibitor, was significantly through suppressing pathway.

Language: Английский

Mannose-Modified Multifunctional Iron-Based Nanozyme for Hepatocellular Carcinoma Treatment by Remodeling the Tumor Microenvironment DOI
Qi Liu, Ziwei Liang, Jiapu Wang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114548 - 114548

Published: Feb. 3, 2025

Language: Английский

Citations

2
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

Citations

9
Therapeutic Approaches with Iron Oxide Nanoparticles to Induce Ferroptosis and Overcome Radioresistance in Cancers DOI Creative Commons
Derek B. Sant’Angelo, Géraldine Descamps, Valentin Lecomte

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 325 - 325

Published: Feb. 26, 2025

The emergence of nanotechnology in medicine, particularly using iron oxide nanoparticles (IONPs), may impact cancer treatment strategies. IONPs exhibit unique properties, such as superparamagnetism, biocompatibility, and ease surface modification, making them ideal candidates for imaging, therapeutic interventions. Their application targeted drug delivery, especially with traditional chemotherapeutic agents like cisplatin, has shown potential overcoming limitations low bioavailability systemic toxicity chemotherapies. Moreover, IONPs, by releasing ions, can induce ferroptosis, a form iron-dependent cell death, which offers promising pathway to reverse radio- chemoresistance therapy. In particular, demonstrate significant radiosensitisers, enhancing the effects radiotherapy promoting reactive oxygen species (ROS) generation, lipid peroxidation, modulating tumour microenvironment stimulate antitumour immune responses. This review explores multifunctional roles radiosensitisation through ferroptosis induction, highlighting their promise advancing head neck cancers. Additional research is crucial fully addressing clinical settings, offering novel approach personalised treatment.

Language: Английский

Citations

1
Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets DOI Creative Commons
Guangpeng Gao, Xindi Zhang

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Language: Английский

Citations

0
Nanozyme as tumor energy homeostasis disruptor mediated ferroptosis for high-efficiency radiotherapy DOI
Xingchen Li, Yuxuan Zhang,

Annan Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 688, P. 44 - 58

Published: Feb. 19, 2025

Language: Английский

Citations

0
Clonogenic assay and computational modeling using real cell images to study physical enhancement and cellular sensitization induced by metal nanoparticles under MV and kV X-ray irradiation DOI Creative Commons

Rodrigo Hernández Millares,

Chaewon Bae,

Seokjin Kim

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(14), P. 7110 - 7122

Published: Jan. 1, 2024

A study on the radiophysical dose enhancement and intrinsic biological sensitization by gold iron nanoparticles in A549 cancer cells.

Language: Английский

Citations

2
Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects DOI Creative Commons

Yuanchun Chen,

Shijie Shangguan,

Zhongyu Lin

et al.

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical tumor treatment through radiotherapy. Despite their widespread use, optimizing X‐ray efficacy remains critical challenge due to issues such as resistance damage surrounding health tissues. Recent advancements nanotechnology have introduced new opportunities challenges cancer diagnosis treatment. This review summarizes the latest progress nanomaterials for X‐ray‐triggered therapy, highlighting various advantages targeted delivery, reduced side effects, enhanced therapeutic efficacy. We examine how nanomaterials, including metals, metal oxides, sulfides, fluorides, rare earth cluster compounds, metal‐organic frameworks, nanohybrids, enhance effectiveness treatments. Furthermore, we address current future prospects efficient aiming provide comprehensive overview researchers clinicians field.

Language: Английский

Citations

2
Inorganic Nanomedicine—Mediated Ferroptosis: A Synergistic Approach to Combined Cancer Therapies and Immunotherapy DOI Open Access
Adityanarayan Mohapatra, Ayeskanta Mohanty, In‐Kyu Park

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3210 - 3210

Published: Sept. 20, 2024

Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has generated substantial interest in cancer therapy. Various methods have been developed to induce ferroptosis tumor cells, including approved drugs, experimental compounds, and nanomedicine formulations. Unlike apoptosis, presents unique molecular cellular features, representing promising approach for cancers resistant conventional treatments. Recent research indicates strong link between the immune microenvironment, suggesting potential trigger robust antitumor responses. Multiple metabolic pathways control ferroptosis, iron, lipid, redox metabolism. Thus, understanding interaction metabolism is crucial developing effective anticancer therapies. This review provides an in-depth discussion on combining inorganic nanoparticles with therapies such as phototherapy, chemotherapy, radiotherapy, immunotherapy, role these combination Furthermore, this paper explores future treatment using nanomedicine, focusing how can enhance cells boost immunity. The goal advance ferroptosis-based from laboratory clinical applications.

Language: Английский

Citations

1
Membrane-Cloaked Nanodrug for Homologous Targeting and Treatment of Therapeutic Stress Escaped Cancer Stem Cells DOI
Weixiao Yan, Z. Li, Liang‐I Kang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25900 - 25910

Published: Nov. 8, 2024

Cancer stem cells (CSCs) often exhibit high expression of the p38/MAPK signaling pathway during therapy, leading to therapeutic stress-induced cellular escape (TSCE) and presenting a significant barrier cancer treatment. Therefore, blocking stress CSCs or simultaneously targeting stress-escaping (TSCSCs) has become crucial strategy in therapy. However, lack specific markers for identifying TSCSCs greatly limited development effective treatments. cell membranes selective binding internalization by similar cells. Herein, we report nanoparticle with Fe3O4@SiO2 as core, which serves carrier load p38 inhibitor is subsequently coated homologous membranes. reported CSC membrane-coated nanoparticles that effectively targeted while minimizing off-target effects, inhibited TSCE tumor growth introducing thermotherapy. The application this nanomaterial holds promise overcoming current treatment challenges providing strategies Fluorescence colocalization vivo imaging demonstrate targets homogeneously effects. Transwell QPCR analyses show inhibits motility BCSCs preventing microtubule reorganization, thereby limiting their from TSCE. Additionally, inhibitor, was significantly through suppressing pathway.

Language: Английский

Citations

0