Soft Matter, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Thiol–ene photoclick chemistry produces chemically crosslinked coacervates with pH and salt tolerance that can encapsulate protect functional biologics.
Язык: Английский
Soft Matter, Год журнала: 2025, Номер 21(10), С. 1781 - 1812
Опубликована: Янв. 1, 2025
Peptide-mediated liquid–liquid phase separation (LLPS) underpins the formation of dynamic biomolecular condensates, regulated by diverse molecular interactions, and highlights potential applications in drug delivery synthetic biology.
Язык: Английский
Процитировано
4
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Coacervates have garnered significant attention as potential drug carriers. However, the instability resulting from their intrinsic membrane-free nature restricts application of coacervates in delivery. Herein, engineering poly(ethylene glycol) nanoparticles (PEG NPs) is reported using composed PEG and polyphenols templates, where subsequently cross-linked based on different chemistries (e.g., thiol-disulfide exchange, click chemistry, Schiff base reaction). The assembly strategy avoids template removal process resultant NPs exhibit excellent stability physiological environment compared to coacervates. presence enables loading various cargos including metal ions (i.e., Ru, Gd, Mn, Fe) molecules doxorubicin), which demonstrates promise magnetic resonance imaging combinational tumor therapy. This work provides a promising promote development coacervate-derived delivery system for biomedical applications.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 1, 2024
Orally administered nanocarriers play an important role in improving druggability, promoting intestinal absorption, and enhancing therapeutic applications for the treatment of local systemic diseases. However, delivering efficiency cell response mucosa to orally is affected by physiological environment barriers gastrointestinal tract, physicochemical properties nanocarriers, their bidirectional interactions. Goblet cells secrete form extracellular mucus, which hinders movement nanoparticles. Meanwhile, epithelial may absorb NPs, allowing transcytosis or degradation. Conversely, nanoparticle-induced toxicity occur as a biological nanoparticle exposure. Additionally, immune functions secretions such mucin, peptide, cytokines also be altered. In this review, we discuss interactions between nanoparticles focusing on enterocytes goblet cells, M according essential crosstalk with cells. Furthermore, recent advances how physiochemical influence interplay, delivery, fate mucosa. Understanding different from perspective interaction provides support development, rational design, potency maximation, application advanced oral nanocarrier delivery systems.
Язык: Английский
Процитировано
3
Phytotherapy Research, Год журнала: 2024, Номер 38(9), С. 4592 - 4613
Опубликована: Июль 30, 2024
Abstract Magnoflorine (Mag), a natural alkaloid component originating from the Ranunculaceae Juss . Family, has various of pharmacological activities. This study aimed to investigate therapeutic effects and potential mechanism Mag on dextran sulfate sodium (DSS)‐induced ulcerative colitis (UC) based comprehensive approaches. Therapeutic 3% DSS‐induced UC mice were analyzed. UHPLC‐Q‐TOF/MS was performed metabolites signaling pathway UC. Furthermore, predicted mRNA protein levels JAK2/STAT3 in colon tissue verified assessed by qRT‐PCR Western Blotting, respectively. presented down‐regulation serum biochemical indices, alleviating histological damage tissue. Serum untargeted metabolomics analysis showed that is mainly associated with regulation six biomarkers 11 pathways, which may be responsible for efficacy The “component–metabolites–targets” interactive network indicated exerts its anti‐UC effect regulating PTGS1 PTGS2, thereby arachidonic acid. Moreover, results could substantially decrease relative expression level Hub genes. In addition, it found inhibit pathway. present highlighted role ameliorated injury inhibiting These suggest an effective agent treatment
Язык: Английский
Процитировано
2
Analytical Chemistry, Год журнала: 2024, Номер 96(47), С. 18852 - 18858
Опубликована: Ноя. 15, 2024
Ulcerative colitis (UC) is an inflammatory disease that leads to the overexpression of peroxynitrite (ONOO
Язык: Английский
Процитировано
2
Soft Matter, Год журнала: 2024, Номер unknown
Опубликована: Дек. 6, 2024
Coacervation emerges as a cutting-edge approach to enhance drug delivery, vaccines, and other therapeutics offer potential improvements in their efficacy. Figure created BioRender. Mirlohi, K. (2024) https://BioRender.com/c81q692.
Язык: Английский
Процитировано
2
Biomacromolecules, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 6, 2024
This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These achieved high drug entrapment efficiencies (80–90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking sonication. The stable, negative zeta potentials (−20 to −30 mV) particle sizes between 100 200 nm. Fourier-transform infrared analysis confirmed successful methacrylation GelMA nanogels. Sustained BOSU release at pH 5.0 was observed, resembling tumor environments, compared slower normal (7.4). Cytotoxicity tests showed 70–80% cell survival reduction HCT116 cells higher doses, GelMA-BOSU notably reduced migration. Antiangiogenic effects a chick chorioallantoic membrane model, highlighting potential these targeted delivery therapy.
Язык: Английский
Процитировано
1
Soft Matter, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Thiol–ene photoclick chemistry produces chemically crosslinked coacervates with pH and salt tolerance that can encapsulate protect functional biologics.
Язык: Английский
Процитировано
0