Regulation of cancer-associated fibroblasts for enhanced cancer immunotherapy using advanced functional nanomedicines: an updated review
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 4, 2025
The
tumor
microenvironment
(TME)
is
a
complex
and
dynamic
ecosystem
that
plays
critical
role
in
cancer
progression.
It
comprises
various
cell
types,
including
immune
cells,
stromal
cells.
Among
these,
cancer-associated
fibroblasts
(CAFs)
represent
heterogeneous
population
with
diverse
origins,
phenotypes,
functions.
Activated
CAFs
secrete
multiple
factors
promote
growth,
migration,
angiogenesis,
contribute
to
chemoresistance.
Additionally,
extracellular
matrix
(ECM)
components,
such
as
collagen,
which
form
physical
barrier
hinders
the
penetration
of
chemotherapeutic
immunotherapeutic
agents.
This
ECM
also
influences
infiltration,
impeding
their
ability
effectively
target
As
result,
modulating
activity
has
emerged
promising
strategy
enhance
efficacy
immunotherapy.
Nano-delivery
systems,
constructed
from
nanomaterials
high
targeting
specificity
biocompatibility,
offer
compelling
approach
deliver
therapeutic
agents
or
immunomodulatory
directly
CAFs.
modulation
can
alter
CAF
function,
reduce
tumor-promoting
effects,
thereby
improve
outcomes
review
provides
an
in-depth
exploration
functions,
interactions
within
TME,
particularly
context
suppression.
Furthermore,
it
discusses
potential
applications
functional
nanocarrifers
enhancing
effectiveness
immunotherapy,
highlighting
significant
progress
nanotechnology
this
area.
Язык: Английский
Chitosan-based hydrogels in cancer therapy: Drug and gene delivery, stimuli-responsive carriers, phototherapy and immunotherapy
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
282, С. 137047 - 137047
Опубликована: Ноя. 1, 2024
Язык: Английский
Mitochondrial DNA-activated cGAS-STING pathway in cancer: Mechanisms and therapeutic implications
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
1880(1), С. 189249 - 189249
Опубликована: Дек. 17, 2024
Язык: Английский
Role of reactive oxygen species in regulating epigenetic modifications
Cellular Signalling,
Год журнала:
2024,
Номер
125, С. 111502 - 111502
Опубликована: Ноя. 7, 2024
Язык: Английский
H2O2 self-supplying nanoparticles for chemodynamic and synergistic photodynamic therapy to augment cGAS/STING activation
Nanoscale,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Triple
negative
breast
cancer
(TNBC)
characterized
by
easy
metastasis
and
poor
prognosis
is
one
of
the
most
intractable
malignancies.
Язык: Английский
Nanodrug combining chemotherapy and ferroptosis mediated cGAS-STING activation for potent antitumor immunity
New Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Triple-negative
breast
cancer
(TNBC)
presents
a
significant
challenge
in
treatment
due
to
its
aggressive
and
immunosuppressive
tumor
microenvironment
(TME).
Язык: Английский
Polymer‐Conjugated SOD‐Pt⁰ Micelles Enhance ROS Cascade Scavenging to Alleviate Ischemia‐Reperfusion Injury During Kidney Transplantation
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
Abstract
Ischemia‐reperfusion
injury
(IRI)
during
kidney
transplantation
is
linked
to
oxidative
stress
induced
by
excessive
reactive
oxygen
species
(ROS),
which
causes
the
of
transplanted
kidney,
leading
further
intensified
organ
shortages.
Protein‐based
antioxidants
have
been
developed
for
ROS
scavenging
via
cascade
biocatalyst.
The
in
situ
growth
metal
nanozymes
on
proteins
effectively
decreases
steric
hindrance
between
active
sites,
improving
efficiency
biocatalysts.
However,
poor
stability
protein
process
preparation
and
intracellular
delivery
leads
low
therapeutic
effects.
In
this
study,
three
different
functional
polymers
are
conjugated
SOD
formation
micelles.
Surprisingly,
it
found
that
ultra‐acid
sensitive
polymer
efficiently
preserves
enzymatic
activity
SOD,
due
great
endo/lysosomal
escape
capacity.
Subsequently,
micelles
(SOE)
used
as
a
template
prepare
SOE‐Pt
0
(SOEP)
through
Pt
with
vicinal
sites.
minimally
impacts
owing
improved
stability.
system
exhibits
effective
scavenging,
significantly
reducing
damage
inflammation
caused
IRI.
research
offers
novel
approach
addressing
IRI
challenges
provides
promising
strategy
mitigate
Язык: Английский