Polymer‐Conjugated SOD‐Pt⁰ Micelles Enhance ROS Cascade Scavenging to Alleviate Ischemia‐Reperfusion Injury During Kidney Transplantation DOI
Shengzhou Li, Fei Duan,

Zhiwen Qiu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Abstract Ischemia‐reperfusion injury (IRI) during kidney transplantation is linked to oxidative stress induced by excessive reactive oxygen species (ROS), which causes the of transplanted kidney, leading further intensified organ shortages. Protein‐based antioxidants have been developed for ROS scavenging via cascade biocatalyst. The in situ growth metal nanozymes on proteins effectively decreases steric hindrance between active sites, improving efficiency biocatalysts. However, poor stability protein process preparation and intracellular delivery leads low therapeutic effects. In this study, three different functional polymers are conjugated SOD formation micelles. Surprisingly, it found that ultra‐acid sensitive polymer efficiently preserves enzymatic activity SOD, due great endo/lysosomal escape capacity. Subsequently, micelles (SOE) used as a template prepare SOE‐Pt 0 (SOEP) through Pt with vicinal sites. minimally impacts owing improved stability. system exhibits effective scavenging, significantly reducing damage inflammation caused IRI. research offers novel approach addressing IRI challenges provides promising strategy mitigate

Language: Английский

Regulation of cancer-associated fibroblasts for enhanced cancer immunotherapy using advanced functional nanomedicines: an updated review DOI Creative Commons
Tingting Liao, Xiaoxiao Chen,

Fengkai Qiu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

The tumor microenvironment (TME) is a complex and dynamic ecosystem that plays critical role in cancer progression. It comprises various cell types, including immune cells, stromal cells. Among these, cancer-associated fibroblasts (CAFs) represent heterogeneous population with diverse origins, phenotypes, functions. Activated CAFs secrete multiple factors promote growth, migration, angiogenesis, contribute to chemoresistance. Additionally, extracellular matrix (ECM) components, such as collagen, which form physical barrier hinders the penetration of chemotherapeutic immunotherapeutic agents. This ECM also influences infiltration, impeding their ability effectively target As result, modulating activity has emerged promising strategy enhance efficacy immunotherapy. Nano-delivery systems, constructed from nanomaterials high targeting specificity biocompatibility, offer compelling approach deliver therapeutic agents or immunomodulatory directly CAFs. modulation can alter CAF function, reduce tumor-promoting effects, thereby improve outcomes review provides an in-depth exploration functions, interactions within TME, particularly context suppression. Furthermore, it discusses potential applications functional nanocarrifers enhancing effectiveness immunotherapy, highlighting significant progress nanotechnology this area.

Language: Английский

Citations

3
Chitosan-based hydrogels in cancer therapy: Drug and gene delivery, stimuli-responsive carriers, phototherapy and immunotherapy DOI

Hailin Zhu,

Haowei Sun, Jingyuan Dai

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137047 - 137047

Published: Nov. 1, 2024

Language: Английский

Citations

5
Mitochondrial DNA-activated cGAS-STING pathway in cancer: Mechanisms and therapeutic implications DOI

Lintao Xia,

Xiuli Yan, Hui Zhang

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1880(1), P. 189249 - 189249

Published: Dec. 17, 2024

Language: Английский

Citations

5
Role of reactive oxygen species in regulating epigenetic modifications DOI
Yutong Chen, Yingqiang Shen

Cellular Signalling, Journal Year: 2024, Volume and Issue: 125, P. 111502 - 111502

Published: Nov. 7, 2024

Language: Английский

Citations

4
H2O2 self-supplying nanoparticles for chemodynamic and synergistic photodynamic therapy to augment cGAS/STING activation DOI
Ai-Hong Zhang,

Wei‐Chuang Kong,

Xiaolei Zhang

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Triple negative breast cancer (TNBC) characterized by easy metastasis and poor prognosis is one of the most intractable malignancies.

Language: Английский

Citations

0
Nanodrug combining chemotherapy and ferroptosis mediated cGAS-STING activation for potent antitumor immunity DOI
Shengtao Li,

Chenchen Li,

Xing‐Hu Wu

et al.

New Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Triple-negative breast cancer (TNBC) presents a significant challenge in treatment due to its aggressive and immunosuppressive tumor microenvironment (TME).

Language: Английский

Citations

0
Polymer‐Conjugated SOD‐Pt⁰ Micelles Enhance ROS Cascade Scavenging to Alleviate Ischemia‐Reperfusion Injury During Kidney Transplantation DOI
Shengzhou Li, Fei Duan,

Zhiwen Qiu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Abstract Ischemia‐reperfusion injury (IRI) during kidney transplantation is linked to oxidative stress induced by excessive reactive oxygen species (ROS), which causes the of transplanted kidney, leading further intensified organ shortages. Protein‐based antioxidants have been developed for ROS scavenging via cascade biocatalyst. The in situ growth metal nanozymes on proteins effectively decreases steric hindrance between active sites, improving efficiency biocatalysts. However, poor stability protein process preparation and intracellular delivery leads low therapeutic effects. In this study, three different functional polymers are conjugated SOD formation micelles. Surprisingly, it found that ultra‐acid sensitive polymer efficiently preserves enzymatic activity SOD, due great endo/lysosomal escape capacity. Subsequently, micelles (SOE) used as a template prepare SOE‐Pt 0 (SOEP) through Pt with vicinal sites. minimally impacts owing improved stability. system exhibits effective scavenging, significantly reducing damage inflammation caused IRI. research offers novel approach addressing IRI challenges provides promising strategy mitigate

Language: Английский

Citations

0