Опубликована: Июль 4, 2024
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(31)
Опубликована: Июнь 18, 2024
Since two-dimensionalal (2D) materials have distinct chemical and physical properties, they are widely used in various sectors of modern technologies. In the domain diagnostic biodevices, particularly for point-of-care (PoC) biomedical diagnostics, 2D-based field-effect transistor biosensors (bio-FETs) demonstrate substantial potential. Here, this review article, operational mechanisms detection capabilities biosensing devices utilizing graphene, transition metal dichalcogenides (TMDCs), black phosphorus, other 2D addressed detail. The incorporation these into FET-based offers significant advantages, including low limits (LOD), real-time monitoring, label-free diagnosis, exceptional selectivity. also highlights diverse applications biosensors, ranging from conventional to wearable devices, underscoring versatility material-based FET devices. Additionally, provides a comprehensive assessment limitations challenges faced by along with insights future prospects advancements. Notably, detailed comparison is tabulated platforms their working mechanisms. Ultimately, aims stimulate further research innovation field while educating scientific community about latest advancements materials-based biosensors.
Язык: Английский
Процитировано
19
ACS Sensors, Год журнала: 2024, Номер 9(6), С. 2705 - 2727
Опубликована: Июнь 6, 2024
The ultrasensitive recognition of biomarkers plays a crucial role in the precise diagnosis diseases. Graphene-based field-effect transistors (GFET) are considered most promising devices among next generation biosensors. GFET biosensors possess distinct advantages, including label-free, ease integration and operation, ability to directly detect liquid environments. This review summarized recent advances for biomarker detection, with focus on interface functionalization. Various sensitivity-enhancing strategies have been overviewed biosensors, from perspective optimizing graphene synthesis transfer methods, refinement surface functionalization channel layer gate electrode, design biorecognition elements reduction nonspecific adsorption. Further, this extensively explores functionalized antibodies, aptamers, enzymes. It delves into employed detection various diseases (such as cancer, cardiovascular diseases, neurodegenerative disorders, infectious viruses, etc.) along their application integrated microfluidic systems. Finally, issues challenges modulation biosensing interfaces faced by detecting biomarkers.
Язык: Английский
Процитировано
15
Discover Nano, Год журнала: 2024, Номер 19(1)
Опубликована: Июнь 17, 2024
Abstract Graphene-based nanomaterials (graphene, graphene oxide, reduced quantum dots, graphene-based nanocomposites, etc.) are emerging as an extremely important class of primarily because their unique and advantageous physical, chemical, biological, optoelectronic aspects. These features have resulted in uses across diverse areas scientific research. Among all other applications, they found to be particularly useful designing highly sensitive biosensors. Numerous studies established efficacy sensing pathogens biomolecules allowing for the rapid diagnosis various diseases. Considering growing importance popularity materials biosensing this review aims provide readers with a summary recent progress concerned domain highlights challenges associated synthesis application these multifunctional materials.
Язык: Английский
Процитировано
8
Biosensors and Bioelectronics, Год журнала: 2024, Номер unknown, С. 117092 - 117092
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
8
Talanta, Год журнала: 2024, Номер 279, С. 126604 - 126604
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
5
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Май 14, 2025
Abstract In recent years, monoelemental 2D materials (Xenes) such as graphene, graphdiyne, silicene, phosphorene, and tellurene, have gained significant traction in biosensing applications. Owing to their ultra‐thin layered structure, exceptionally high specific surface area, unique electronic properties, excellent mechanical strength, flexibility, other distinctive features, Xenes are recognized for potential with low detection limits, speed, exceptional flexibility this review, the properties of Xenes, synthesis, theoretical experimental advances applications related biosensing, including DNA/RNA biosensors, protein small molecule cell, ion biosensors comprehensively summarized. Finally, challenges prospects emerging field discussed.
Язык: Английский
Процитировано
0
Nanoscale, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This paper provides a comprehensive review of the latest research advancements in overcoming Debye screening effect field-effect transistor (FET) sensors.
Язык: Английский
Процитировано
3
Talanta Open, Год журнала: 2024, Номер unknown, С. 100394 - 100394
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
3
Langmuir, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
The detection of carbohydrate antigen 19–9 (CA199), a critical biomarker for pancreatic, colorectal, and gastric cancers, is essential early diagnosis disease monitoring. Traditional antibody-based assays CA199 are limited by high costs, time-consuming procedures, susceptibility to nonspecific interference. This study presents an electrochemical biosensor based on multifunctional poly(EDOT-PyBA-co-EDOT-PEG) copolymer designed overcome these limitations. integrates pyridylboronic acid (PyBA) moieties specific recognition sialic residues poly(ethylene glycol) (PEG) chains antifouling properties within conductive PEDOT framework. By eliminating antibody dependency, the reduces enhances stability, simplifies diagnostic process. Surface characterization confirmed successful incorporation PyBA PEG units, while impedance spectroscopy enabled sensitive with limit 0.05 U·mL–1 linear response range from 40 U·mL–1. Recovery tests in spiked human serum samples demonstrated excellent accuracy (97–109% recovery), validating biosensor's reliability complex biological matrices. rationally provides both sensitivity specificity maintaining resistance biofouling samples. work establishes scalable, cost-effective platform glycoprotein detection, advancing field clinical diagnostics cancer
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 5, 2025
We designed, developed, and clinically tested two rapid antigen-based immunosensors for SARS-CoV-2 detection, enabling diagnosis viral load quantification under USD $2. In a first clinical study, screen-printed disposable carbon-based (SPC) sensor was assessed on prospectively recruited adult participants classified into three study groups: healthy donors (n = 46); SARS-CoV-2-infected symptomatic patients 58); co-habitants of without prior testing 38). Nasopharyngeal aspirates (NA), oropharyngeal swabs (OS), saliva (SA) samples were obtained from all participants. Performance measured in terms sensitivity specificity against reference diagnostic RT-qPCR kit analytical (limit LoD) using recombinant material lab tests. A second performed the same design, albeit with laser-induced graphene (LIG) electrodes, nasopharyngeal (NS) 224 patient at different stages pandemic, which 110 negative 114 positive via RT-qPCR. find OS most informative sample, when compared to NA SA. The SPC-based sensors had 93.8% 61.5% samples, while LIG-based NS lower 68.93%, significantly higher 86.17%. believe values SPC driven by results affected low (75.5%) high LoD (> 20,000 copies/mL) used, due reduced set effective antigen-binding sites caused non-covalent LIG-mAb ligands used. immunosensor's spike protein phosphate-buffered saline (PBS) both types near 1 fg/mL showed no cross-reactivity structural proteins Epstein-Barr Influenza. metrics time-to-result (5 < 12 min) provide proof-of-principle applicability as low-cost, technology determining infections. Changing working electrode LIG, instead SPC, improved even presence pathogen variants. Discordant between our immunosensor versions tests are attributed not only limited antibody effectiveness former but also quality probes used height pandemic.
Язык: Английский
Процитировано
0