Surface loading of nanoparticles on engineered or natural erythrocytes for prolonged circulation time: strategies and applications

Acta Pharmacologica Sinica, Год журнала: 2021, Номер 42(7), С. 1040 - 1054

Опубликована: Март 26, 2021

Язык: Английский

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Red Blood Cell Inspired Strategies for Drug Delivery: Emerging Concepts and New Advances

Pharmaceutical Research, Год журнала: 2022, Номер 39(11), С. 2673 - 2698

Опубликована: Июль 7, 2022

Язык: Английский

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Antimicrobial micro/nanorobotic materials design: From passive combat to active therapy

Materials Science and Engineering R Reports, Год журнала: 2022, Номер 152, С. 100712 - 100712

Опубликована: Дек. 19, 2022

Язык: Английский

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A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery

Exploration, Год журнала: 2023, Номер 4(2)

Опубликована: Дек. 10, 2023

Abstract The tumour‐targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome anticancer treatment. Major challenges lie in complexity diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcellular targets. Herein, an “all‐in‐one” red blood cell (RBC)‐derived microrobot can adapt five critical stages during systemic delivery, is, circulation, accumulation, release, extravasation, and penetration, is developed. microrobots behave like natural RBCs due almost identical surface properties, but be magnetically manipulated accumulate at regions interest such as tumours. Next, are “immolated” under laser irradiation release cargoes and, by generating heat, enhance extravasation through vascular barriers. As a coloaded agent, pirfenidone (PFD) inhibit formation extracellular matrix increase penetration depth solid tumour. It demonstrated this system effectively suppresses both primary metastatic tumours mouse models without evident side effects, may represent new class intelligent biomimicking robots for biomedical applications.

Язык: Английский

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From bench to bedside: Platelet biomimetic nanoparticles as a promising carriers for personalized drug delivery

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 128 - 144

Опубликована: Июль 14, 2024

Язык: Английский

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