Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 16, 2024
Red
blood
cells
(RBCs)
naturally
trap
some
bacterial
pathogens
in
the
circulation
and
kill
them
by
oxidative
stress.
Following
neutralization,
bacteria
are
presented
to
antigen-presenting
spleen
RBCs.
This
ability
of
RBCs
has
been
harnessed
develop
a
system
where
they
play
crucial
role
enhancing
immune
response,
offering
novel
approach
enhance
body’s
immunity.
In
this
work,
conjugate,
G-OVA,
was
formed
connecting
β-glucan
OVA
through
disulfide
bond.
Poly
(lactic-co-glycolic
acid)
(PLGA)
then
employed
encapsulate
yielding
G-OVA-PLGA.
Finally,
nanoparticles
were
adsorbed
onto
G-OVA-PLGA@RBC.
The
results
demonstrated
that
delivery
enhanced
antibody
response
antigens
both
vitro
vivo
.
objective
study
investigate
increased
activity
G-OVA-PLGA
facilitated
transportation
elucidate
its
underlying
mechanisms.
These
findings
anticipated
contribute
valuable
insights
for
development
efficient
safe
enhancers.
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Micromachines,
Год журнала:
2022,
Номер
13(12), С. 2091 - 2091
Опубликована: Ноя. 27, 2022
The
potential
use
of
nanomaterials
in
medicine
offers
opportunities
for
novel
therapeutic
approaches
to
treating
complex
disorders.
For
that
reason,
a
new
branch
science,
named
nanotoxicology,
which
aims
study
the
dangerous
effects
on
human
health
and
environment,
has
recently
emerged.
However,
toxicity
risk
associated
with
are
unclear
or
not
completely
understood.
development
an
adequate
experimental
strategy
assessing
may
include
rapid/express
method
will
reliably,
quickly,
cheaply
make
initial
assessment.
One
possibility
is
characterization
hemocompatibility
nanomaterials,
includes
their
hemolytic
activity
as
marker.
In
this
review,
we
consider
various
factors
affecting
draw
reader’s
attention
fact
formation
protein
corona
around
nanoparticle
can
significantly
change
its
interaction
red
cell.
This
leads
us
suggest
nanomaterial
buffer
does
reflect
situation
blood
plasma.
As
recommendation,
propose
studying
under
more
physiologically
relevant
conditions,
presence
plasma
proteins
medium
mechanical
stress.
Symmetry,
Год журнала:
2023,
Номер
15(2), С. 403 - 403
Опубликована: Фев. 3, 2023
Metal-organic
frameworks
(MOFs)
are
a
new
class
of
porous
crystalline
materials
composed
metal
and
organic
material.
MOFs
have
fascinating
properties,
such
as
fine
tunability,
large
specific
surface
area,
high
porosity.
widely
used
for
environmental
protection,
biosensors,
regenerative
medicine,
medical
engineering,
cell
therapy,
catalysts,
drug
delivery.
Recent
studies
reported
various
significant
properties
biomedical
applications,
detection
In
contrast,
limitations
low
stability
specificity
in
binding
to
the
target.
MOF-based
membranes
improve
conventional
by
increasing
area
developing
possibility
MOF-ligand
binding,
while
conjugated
dramatically
increase
active
functional
groups.
This
special
property
makes
them
attractive
biosensor
fabrication,
both
spreading
solubility
components
porosity
can
be
changed.
Asymmetric
structure
with
potential
field,
due
different
characteristics
on
its
two
surfaces,
adjusting
size
porosity,
transfer
rate
selectivity,
hydrophilicity
hydrophobicity.
MOF
assisted
asymmetric
provide
platform
field.
The
latest
version
materials/membranes
has
several
especially
delivery,
which
will
discussed
this
review,
along
their
advantages,
disadvantages,
challenges.
Metal-Organic
Frameworks
(MOFs)
are
versatile
materials
with
tailorable
structures,
high
surface
areas,
and
controlled
pore
sizes,
making
them
ideal
for
gas
storage,
separation,
catalysis,
notably
wastewater
treatment
by
removing
pollutants
like
antibiotics
heavy
metals.
Functionalization
enhances
their
applications
in
energy
conversion
environmental
remediation.
Despite
challenges
stability
cost,
ongoing
innovation
MOFs
contributes
to
the
circular
economy
aligns
Sustainable
Development
Goals.
Arteriosclerosis Thrombosis and Vascular Biology,
Год журнала:
2023,
Номер
43(5), С. 628 - 636
Опубликована: Март 16, 2023
Recent
studies
have
demonstrated
a
novel
function
of
red
blood
cells
(RBCs)
beyond
their
classical
role
as
gas
transporters,
that
is,
RBCs
undergo
functional
alterations
in
cardiovascular
and
metabolic
disease,
RBC
dysfunction
is
associated
with
hypertension
the
development
injury
type
2
diabetes,
heart
failure,
preeclampsia,
familial
hypercholesterolemia/dyslipidemia,
COVID-19.
The
underlying
mechanisms
include
decreased
nitric
oxide
bioavailability,
increased
arginase
activity,
reactive
oxygen
species
formation.
Of
interest,
contain
diverse
abundant
micro
(mi)RNAs.
miRNA
expression
pattern
reflects
whole
blood,
serum,
plasma.
levels
been
found
to
be
altered
various
diseases,
which
contributes
complications.
Evidence
has
shown
RBC-derived
miRNAs
interact
system
via
extracellular
vesicles
argonaute
RISC
catalytic
component
carriers.
Alteration
RBC-to-vascular
communication
may
serve
potential
disease
mechanism
for
vascular
present
review
summarizes
released
mediators
injury.
We
further
focus
on
possible
by
regulate
function.
A
better
understanding
will
increase
insights
into
targets
treatment
Theranostics,
Год журнала:
2023,
Номер
14(1), С. 220 - 248
Опубликована: Ноя. 15, 2023
Red
blood
cells
(RBCs)
are
the
most
abundant
cell
type
in
blood,
and
play
a
critical
role
oxygen
transport.With
development
of
nanobiotechnology
synthetic
biology,
scientists
have
found
multiple
ways
to
take
advantage
characteristics
RBCs,
such
as
their
long
circulation
time,
construct
universal
develop
drug
delivery
systems,
transform
therapies
for
cancer
other
diseases.This
article
reviews
component
aging
mystery
methods
applied
application
prospects
engineering
modification
RBCs
used
cytopharmaceuticals
immunotherapy.Finally,
we
summarize
some
perspectives
on
biological
features
provide
further
insights
into
translational
medicine.
Advanced Materials,
Год журнала:
2023,
Номер
36(14)
Опубликована: Дек. 30, 2023
Natural
materials
are
anisotropic.
Delivery
systems
occurring
in
nature,
such
as
viruses,
blood
cells,
pollen,
and
many
others,
do
have
anisotropy,
while
delivery
made
artificially
mostly
isotropic.
There
is
apparent
complexity
engineering
anisotropic
particles
or
capsules
with
micron
submicron
sizes.
Nevertheless,
some
promising
examples
of
how
to
fabricate
shapes
having
chemical
and/or
physical
properties
developed.
Anisotropy
particles,
once
they
face
biological
systems,
influences
their
behavior.
Internalization
by
the
flow
bloodstream,
biodistribution
over
organs
tissues,
directed
release,
toxicity
regardless
same
chemistry
all
reported
be
factors
anisotropy
systems.
Here,
current
methods
reviewed
introduce
capsules,
including
loading
various
therapeutic
cargo,
variable
primarily
magnetic
properties,
controlling
directional
motion,
making
Janus
particles.
The
advantages
combining
different
one
entity
for
common
problems
limitations
fabrication
under
discussion.
