Advanced Materials Technologies,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 2, 2024
Abstract
Over
the
past
decade,
significant
advancements
in
micro‐nano
robots
have
enabled
non‐invasive
operations
hazardous,
confined
environments,
particularly
targeting
persistent
bacterial
biofilms
hard‐to‐reach
areas.
However,
many
of
these
are
limited
by
poor
magnetic
properties,
hindering
their
effectiveness
against
biofilms.
This
study
proposes
a
novel
strategy
using
swarm
with
strong
effects
(Hercules
swarm)
combined
near‐infrared
(NIR)
light
for
effective
biofilm
eradication.
Carbonyl
iron
particles
coated
polydopamine
(CI@PDA),
averaging
≈3
µm
diameter,
demonstrate
clustering
and
magneto‐force
under
rotating
field
due
to
large
saturation.
enables
Hercules
achieve
rapid
delivery
(100
mm
s
−1
),
efficient
cargo
transport
(carrying
twice
its
own
weight),
catheter
clearance
(1
min
).
The
controllable
motion
high
photothermal
activity
enable
precise
eradication
without
toxic
agents.
aggregation
into
chains
rotation
explored
improved
particle
dynamic
model.
Simulations
also
reveal
enhanced
fluid
convection
mechanical
pressure
around
chain.
Due
easy
operation,
straightforward
controllability,
environmental
compatibility,
emerges
as
promising
treatment
modality
eliminating
entrenched
within
intricate,
narrow,
convoluted
medical
implants
or
industrial
conduits.
ACS Nano,
Год журнала:
2023,
Номер
17(16), С. 15962 - 15977
Опубликована: Авг. 3, 2023
Treatment
of
diabetic
foot
ulcers
(DFU)
needs
to
reduce
inflammation,
relieve
hypoxia,
lower
blood
glucose,
promote
angiogenesis,
and
eliminate
pathogenic
bacteria,
but
the
therapeutic
efficacy
is
greatly
limited
by
diversity
synergy
drug
functions
as
well
DFU
microenvironment
itself.
Herein,
an
ultrasound-augmented
multienzyme-like
nanozyme
hydrogel
spray
was
developed
using
hyaluronic
acid
encapsulated
l-arginine
ultrasmall
gold
nanoparticles
Cu1.6O
coloaded
phosphorus
doped
graphitic
carbon
nitride
nanosheets
(ACPCAH).
This
possesses
five
types
enzyme-like
activities,
including
superoxide
dismutase
(SOD)-,
catalase
(CAT)-,
glucose
oxidase
(GOx)-,
peroxidase
(POD)-,
nitric
oxide
synthase
(NOS)-like
activities.
The
kinetics
reaction
mechanism
sonodynamic/sonothermal
synergistic
enhancement
SOD-CAT-GOx-POD/NOS
cascade
ACPCAH
are
fully
investigated.
Both
in
vitro
vivo
tests
demonstrate
that
this
can
be
activated
thus
accelerating
wound
healing
effectively.
study
highlights
a
competitive
approach
based
on
nanozymes
for
development
all-in-one
therapies.
Biomaterials Science,
Год журнала:
2023,
Номер
11(9), С. 3051 - 3076
Опубликована: Янв. 1, 2023
This
review
offers
systematic
considerations
of
material
design
principles
and
fabrication
techniques
for
biomimetic
skin
tissue
engineering
scaffolds.
Advanced Materials,
Год журнала:
2023,
Номер
36(17)
Опубликована: Июль 20, 2023
Abstract
The
discovery
of
antibiotics
has
saved
millions
lives,
but
the
emergence
antibiotic‐resistant
bacteria
become
another
problem
in
modern
medicine.
To
avoid
or
reduce
overuse
antibacterial
treatments,
stimuli‐responsive
materials,
pathogen‐targeting
nanoparticles,
immunogenic
nano‐toxoids,
and
biomimetic
materials
are
being
developed
to
make
sterilization
better
smarter
than
conventional
therapies.
common
goal
smart
(SAMs)
is
increase
antibiotic
efficacy
function
via
an
mechanism
different
from
that
order
biological
properties
while
reducing
risk
drug
resistance.
research
development
SAMs
increasingly
interdisciplinary
because
new
designs
require
knowledge
fields
input/collaboration
scientists
fields.
A
good
understanding
energy
conversion
physiological
characteristics
cells
bacteria,
bactericidal
structures
components
nature
expected
promote
SAMs.
In
this
review,
importance
multidisciplinary
insights
for
emphasized,
latest
advances
categorized
discussed
according
pertinent
disciplines
including
science,
physiology,
biomimicry.
Abstract
Antibiotic
resistance
is
a
major
challenge
in
the
clinical
treatment
of
bacterial
infectious
diseases.
Herein,
we
constructed
multifunctional
DNA
nanoplatform
as
versatile
carrier
for
bacteria‐specific
delivery
antibiotic
ciprofloxacin
(CIP)
and
classic
nanoantibiotic
silver
nanoparticles
(AgNP).
In
our
rational
design,
CIP
was
efficiently
loaded
self‐assembly
double‐bundle
tetrahedron
through
intercalation
with
duplex,
single‐strand
DNA‐modified
AgNP
embedded
cavity
hybridization.
With
site‐specific
assembly
targeting
aptamer
well‐defined
tetrahedron,
dual‐antibiotic
system
exhibited
excellent
combined
bactericidal
properties.
enhanced
accumulation
breaking
out
membrane
bacteria,
effectively
inhibited
biofilm
formation
promoted
healing
infected
wounds
vivo.
This
DNA‐based
provides
promising
strategy
antibiotic‐resistant
infections.
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 11, 2023
Oral
biofilms,
which
are
also
known
as
dental
plaque,
the
culprit
of
a
wide
range
oral
diseases
and
systemic
diseases,
thus
contributing
to
serious
health
risks.
The
manner
how
achieve
good
control
biofilms
has
been
an
increasing
public
concern.
Novel
antimicrobial
biomaterials
with
highly
controllable
fabrication
functionalization
have
proven
be
promising
candidates.
However,
previous
reviews
generally
emphasized
physicochemical
properties,
action
mode,
application
effectiveness
those
biomaterials,
whereas
insufficient
attention
given
design
rationales
tailored
different
infection
types
scenarios.
To
offer
guidance
for
better
diversification
anti-oral-biofilm
this
review
details
up-to-date
in
three
aspects:
core
strategies
combating
biofilm,
well
advanced
antibiofilm
capacity
multiple
functions
based
on
improvement
or
combination
abovementioned
strategies.
Thereafter,
insights
existing
challenges
future
biomaterial-assisted
biofilm
treatments
proposed,
hoping
provide
theoretical
basis
reference
subsequent
biomaterials.
Cyborg and Bionic Systems,
Год журнала:
2024,
Номер
5
Опубликована: Янв. 1, 2024
In
the
realm
of
precise
medicine,
advancement
manufacturing
technologies
is
vital
for
enhancing
capabilities
medical
devices
such
as
nano/microrobots,
wearable/implantable
biosensors,
and
organ-on-chip
systems,
which
serve
to
accurately
acquire
analyze
patients’
physiopathological
information
perform
patient-specific
therapy.
Electrospinning
holds
great
promise
in
engineering
materials
components
advanced
devices,
due
demonstrated
ability
advance
development
nanomaterial
science.
Nevertheless,
challenges
limited
composition
variety,
uncontrollable
fiber
orientation,
difficulties
incorporating
fragile
molecules
cells,
low
production
effectiveness
hindered
its
further
application.
To
overcome
these
challenges,
electrospinning
techniques
have
been
explored
manufacture
functional
composites,
orchestrated
structures,
living
constructs,
scale-up
fabrication.
This
review
delves
into
recent
advances
underscores
their
potential
revolutionizing
field
upon
introducing
fundamental
conventional
techniques,
well
discussing
current
future
perspectives.
Micro/nanorobots
(MNRs)
are
envisioned
to
provide
revolutionary
changes
therapies
for
infectious
diseases
as
they
can
deliver
various
antibacterial
agents
or
energies
many
hard-to-reach
infection
sites.
However,
existing
MNRs
face
substantial
challenges
in
addressing
complex
infections
that
progress
from
superficial
deep
tissues.
Here,
we
develop
swarming
magnetic
Fe
3
O
4
@polydopamine-tannic
acid
nanorobots
(Fe
@PDA-TA
NRs)
capable
of
performing
targeted
bacteria
elimination
complicated
bacterial
by
integrating
photothermal
and
chemical
strategies.
The
nanoparticles
(NPs),
serving
building
blocks
the
nanorobots,
fabricated
situ
polymerization
dopamine
followed
TA
adhesion.
When
driven
alternating
fields,
NPs
assemble
into
large
energetic
microswarms
continuously
flowing
forward
with
tunable
velocity.
Thus,
NRs
be
navigated
achieve
rapid
broad
coverage
a
area
distance
rapidly
eradicate
residing
there
upon
exposure
near-infrared
(NIR)
light
due
their
efficient
conversion.
Additionally,
concentrate
at
sites
traversing
through
confined,
narrow,
tortuous
passages,
exerting
sustained
action
surface
TA-induced
easy
cell
adhesion
subsequent
membrane
destruction.
Therefore,
show
great
potential
superficial-to-deep
infections.
This
study
may
inspire
development
future
therapeutic
microsystems
multifunction
synergies,
task
flexibility,
high
efficiency.
