PeerJ,
Год журнала:
2024,
Номер
12, С. e17886 - e17886
Опубликована: Авг. 21, 2024
Cancer
is
a
serious
public
health
problem
worldwide.
Traditional
treatments,
such
as
surgery,
radiotherapy,
chemotherapy,
and
immunotherapy,
do
not
always
yield
satisfactory
results;
therefore,
an
efficient
treatment
for
tumours
urgently
needed.
As
convenient
minimally
invasive
modality,
focused
ultrasound
(FUS)
has
been
used
only
diagnostic
tool
but
also
therapeutic
in
increasing
number
of
studies.
FUS
can
help
treat
malignant
by
inducing
apoptosis.
This
review
describes
the
three
apoptotic
pathways,
cell
clearance,
how
affects
these
pathways.
discusses
role
thermal
cavitation
effects
on
apoptosis,
including
caspase
activity,
mitochondrial
dysfunction,
Ca
2+
elease.
Finally,
this
article
reviews
various
aspects
combination
therapy,
sensitization
radiotherapy
gene
expression
upregulation,
introduction
gases,
to
provide
new
ideas
clinical
tumour
therapy.
ACS Nano,
Год журнала:
2024,
Номер
18(5), С. 3916 - 3968
Опубликована: Янв. 23, 2024
Dynamic
variations
in
the
concentration
and
abnormal
distribution
of
endogenous
biomarkers
are
strongly
associated
with
multiple
physiological
pathological
states.
Therefore,
it
is
crucial
to
design
imaging
systems
capable
real-time
detection
dynamic
changes
for
accurate
diagnosis
effective
treatment
diseases.
Recently,
ratiometric
has
emerged
as
a
widely
used
technique
sensing
due
its
advantage
circumventing
limitations
inherent
conventional
intensity-dependent
signal
readout
methods
while
also
providing
built-in
self-calibration
correction.
Here,
recent
progress
probes
their
applications
outlined.
Ratiometric
classified
according
mechanisms,
photoacoustic
imaging,
optical
including
photoluminescence
self-luminescence
magnetic
resonance
dual-modal
discussed.
The
such
pH,
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
glutathione
(GSH),
gas
molecules,
enzymes,
metal
ions,
hypoxia
discussed
detail.
Additionally,
this
Review
presents
an
overview
challenges
faced
field
along
future
research
directions.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101027 - 101027
Опубликована: Март 16, 2024
Multimodal
imaging,
which
combines
the
strengths
of
two
or
more
imaging
modalities
to
provide
complementary
anatomical
and
molecular
information,
has
emerged
as
a
robust
technology
for
enhancing
diagnostic
sensitivity
accuracy,
well
improving
treatment
monitoring.
Moreover,
application
multimodal
in
guiding
precision
tumor
can
prevent
under-
over-treatment,
thereby
maximizing
benefits
patients.
In
recent
years,
several
intriguing
magneto-optical
nanosystems
with
both
magnetic
optical
properties
have
been
developed,
leading
significant
breakthroughs
field
image-guided
therapy.
These
advancements
pave
way
precise
medicine.
This
review
summarizes
various
types
developed
recently
describes
their
applications
probes
agents
therapeutic
interventions.
Finally,
future
research
development
prospects
are
discussed
along
an
outlook
on
further
biomedical
field.
Biomimetic
nanoparticles
(BioM
NPs)
feature
functionalization
that
imitates
the
biological
surroundings,
endowing
them
with
structure
and
functioning.
BioM
NPs
could
be
covered
biologically
sourced
materials
contain
synthetic
antigen-presenting
cells
structures.
Whenever
used
in
cancer
diagnostics,
outperform
standard
medications
comparable
non-BioM
NPs,
particularly
regarding
circulation
time,
tissue
penetration,
delivery,
toxicity.
The
particles
achieved
extraordinary
results
by
using
cell
material
for
which
avoids
difficult
bottom-up
approaches
aim
to
emulate
such
intricate
diverse
components.
One
area
of
this
rapidly
developing
research
has
gotten
a
lot
interest
is
use
treatment
different
cancers.
However,
best
our
knowledge,
no
published
study
primarily
analysed
current
improvements
therapy,
taking
into
account
most
common
tumours
processes.
As
result,
purpose
present
review
address
gap
first.
discussion
will
next
go
numerous
recent
advances
therapy.
This
cover
mechanics
procedures
as
well
their
utilization
therapeutics.
paper
then
summarizes
existing
knowledge
investigates
limitations
promise
aims
provide
researchers
an
overview
technological
development
It
serves
guide
integrating
future
nanomedicine
applications.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 16, 2024
Abstract
Improving
cancer
therapy
by
targeting
the
adverse
tumor
microenvironment
(TME)
rather
than
cells
presents
a
novel
and
potentially
effective
strategy.
In
this
study,
we
introduced
Fe
x
Mo
y
S
nanoparticles
(NPs),
which
act
as
sequential
bioreactors
to
manipulate
TME.
NPs
were
synthesized
using
thermal
decomposition
modified
with
polyethylene
glycol
(PEG).
Their
morphology,
chemical
composition,
photothermal
properties
characterized.
The
capability
produce
ROS
deplete
GSH
was
evaluated.
Effects
on
CRC
cells,
including
cell
viability,
apoptosis,
glycolysis,
tested
through
various
in
vitro
assays.
I
n
vivo
efficacy
determined
CRC-bearing
mouse
models
patient-derived
xenograft
(PDX)
models.
impact
MAPK
signaling
pathway
metabolism
also
examined.
showed
efficient
catalytic
activity,
leading
increased
production
depletion,
inducing
ferroptosis,
suppressing
glycolysis
cells.
vivo,
significantly
inhibited
growth,
particularly
when
combined
NIR
light
therapy,
indicating
synergistic
effect
of
chemodynamic
therapy.
Biosafety
assessments
revealed
no
significant
toxicity
treated
mice.
RNA
sequencing
suggested
that
immune
processes
within
present
promising
multifaceted
approach
for
treatment,
effectively
while
maintaining
biosafety.
exhibit
potential
clinical
translation,
offering
new
avenue
Abstract
Nanomaterials
have
aroused
great
interests
in
drug
delivery
due
to
their
nanoscale
structure,
facile
modifiability,
and
multifunctional
physicochemical
properties.
Currently,
stimuli‐responsive
nanomaterials
that
can
respond
endogenous
or
exogenous
stimulus
display
strong
potentials
biomedical
applications.
In
comparison
with
conventional
nanomaterials,
improve
therapeutic
efficiency
reduce
the
toxicity
of
drugs
toward
normal
tissues
through
specific
targeting
on‐demand
release
at
pathological
sites.
this
review,
we
summarize
responsive
mechanism
a
variety
stimulus,
including
pH,
redox,
enzymes
within
microenvironment,
as
well
such
thermal
effect,
magnetic
field,
light,
ultrasound.
After
that,
applications
(e.g.,
delivery,
imaging,
theranostics)
diverse
array
common
diseases,
cardiovascular
cancer,
neurological
disorders,
inflammation,
bacterial
infection,
are
presented
discussed.
Finally,
remaining
challenges
outlooks
future
research
directions
for
also
We
hope
review
provide
valuable
guidance
developing
accelerate
diseases
diagnosis
treatment.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(40)
Опубликована: Авг. 6, 2024
Abstract
Tumor‐specific
microRNA
(miRNA)
imaging
strategies
are
critical
for
investigating
mechanisms
associated
with
cancer
progression;
however,
nonspecific
signal
leakage
and
false‐positive
signaling
limit
their
selectivity
efficiency.
In
this
paper,
an
endogenously
activated
self‐reinforced
DNA
lipid
nanodevice
(LND)
spatial‐specific
high‐contrast
of
miRNAs
in
living
cells
animals
is
presented.
The
LND
functionalized
on
cholesterol‐based
micelles
(CLMs)
containing
smart
response
self‐fueling
components
that
display
redox‐activatable
autocatalytic
miRNA
probing
activities,
respectively.
LNDs
initially
silenced
selectively
using
glutathione,
endogenous
microenvironmental
factor
overexpressed
tumor
cells,
to
prevent
leakage.
Subsequently,
circuit
used
tumor‐specific
imaging.
It
demonstrated
robust
CLM
nanoparticles
can
be
easily
assembled
from
a
cholesterol‐conjugated
G‐rich
sequence
by
stirring
buffered
solution,
enabling
the
enter
naturally.
addition,
vitro
vivo
data
illustrate
enhanced
biostability
surface
realized
minimizing
signals,
making
system
ideal
mice.
This
technique
has
great
potential
precise
biomedical
clinical
diagnosis.
Abstract
Current
radiotherapy
(RT)
lacks
the
ability
to
accurately
discriminate
between
tumor
and
healthy
tissues,
resulting
in
significant
radiation‐induced
damage
for
patients.
Therefore,
there
is
an
urgent
need
precise
RT
techniques
that
can
optimize
control
while
minimizing
adverse
effects
on
surrounding
tissues.
In
this
study,
we
developed
a
nanodrug
(AuNR@Peptide)
composed
of
furin‐responsive
RVRR
peptide‐conjugated
AuNRs,
which
integrates
activatable
probe
radiosensitizer
into
single
system
accurate
localization,
enabling
image‐guided
precision
RT.
Upon
reaching
site
after
intravenous
administration,
proteolytic
cleavage
substrates
AuNR@Peptide
by
biomarker
triggers
aggregation
gold
nanorods
(AuNRs)
larger
aggregates,
leading
activation
near‐infrared
(NIR)‐II
photoacoustic
(PA)
signals
precisely
localize
enhance
retention
preventing
migration
backflow
AuNRs.
This
significantly
amplifies
radiosensitivity
efficiency.
The
peak
time
point
at
NIR‐II
PA
signal
was
observed
injection
serves
as
reference
initiating
RT,
demonstrating
substantial
improvement
through
investigations
related
radiosensitization
mechanisms.
integration
imaging
therapy
study
offers
promising
therapeutic
modality
tumors.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(2), С. 41 - 41
Опубликована: Янв. 24, 2025
Nanoparticle-based
X-ray
radiosensitization
strategies
have
garnered
significant
attention
in
recent
years.
However,
the
underlying
mechanisms
of
remain
incompletely
understood.
In
this
work,
we
explore
influence
K-edge
effect
absorption
nanomaterials
on
sensitization.
Due
to
alignment
thulium
(Tm)
with
Bremsstrahlung
peak
energy
spectrum
medical
accelerators,
following
four
different
rare-earth
varying
Tm
percentages
were
designed:
NaTmF4,
NaTm0.6Lu0.4F4,
NaTm0.4Lu0.6F4,
and
NaLuF4.
We
evaluated
ability
generate
secondary
electrons
reactive
oxygen
species
(ROS)
these
nanoparticles.
The
radiosensitizing
was
through
clonogenic
assays.
Our
results
showed
that
affected
electron
generation
but
did
not
significantly
change
ROS
production.
Nonetheless,
NaTmF4
induced
marginally
more
DNA
damage
U87
cells
than
other
cell
types.
also
exhibited
superior
efficacy
against
tumor
cells.
This
shows
play
pivotal
roles
radiosensitization,
which
might
be
crucial
improving
cancer
treatment
enhanced
radiation
therapy
outcomes.
