Metal-organic
frameworks
(MOFs)
have
attracted
significant
attention
for
their
versatility
in
therapeutic
and
diagnostic
roles,
yet
potential
impact
on
pulmonary
toxicity
remains
largely
unexplored.
There
is
an
urgent
necessity
to
comprehensively
investigate
biological
impacts.
Herein,
we
examined
the
cytotoxicity,
oxidative
stress,
injury
after
UIO-66,
ZIF-8,
MOF-199
stimulation,
with
a
focus
lung
cells
tissue.
Crucially,
our
mechanistic
investigations
definitively
elucidated
that
of
primarily
driven
by
excessive
generation
superoxide
anion
(O2-•).
This
superoxide-driven
ROS
cascade
subsequently
underlies
observed
cellular
damage,
including
calcium
dysregulation
apoptosis,
instigates
inflammatory
response
leading
tissue
injury.
Conversely,
UIO-66
ZIF-8
generated
minimal
level.
study
provides
crucial
insights
into
safety
MOFs
stresses
need
careful
design
optimize
both
functionality
biocompatibility
safe
biomedical
use.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(28), С. 11463 - 11471
Опубликована: Июль 4, 2024
In
this
work,
we
reported
a
cholesterol
oxidase
(Chox)-loaded
platinum
(Pt)
nanozyme
with
the
collaborative
cascade
nanoreactor
for
construction
of
nanozyme-enzyme-linked
immunosorbent
assay
(N-ELSA)
models
to
realize
high-throughput
rapid
evaluation
cancer
markers.
Considering
high
specific
surface
area
and
manipulable
sites,
ZIF-8
was
used
as
substrate
natural
enzyme
loading.
The
constructed
ZIF-8-Pt
platform
exhibited
efficient
enzyme-like
catalytic
efficiency
standard
corrected
activity
60.59
U
mg
ACS Applied Energy Materials,
Год журнала:
2024,
Номер
7(8), С. 3061 - 3070
Опубликована: Апрель 10, 2024
Developing
highly
efficient
electrocatalysts
toward
oxygen
reduction
reaction
is
significant
for
Zn–air
battery
(ZAB),
which
still
arduous.
In
this
work,
based
on
a
metal
vacancy
strategy,
we
synthesized
an
atomically
dispersed
Zn,
Fe
dual-atom
catalyst
N-doped
carbon
(Zn,
Fe/NC)
by
pyrolyzing
the
ZIF-8,
postadsorbing
Fe3+,
and
second
pyrolysis
steps.
Due
to
introduction
of
atoms,
obtained
Fe/NC-800
displays
outstanding
performance
in
alkaline
electrolyte
(half-wave
potential:
0.881
V),
approaches
closely
that
commercial
Pt/C
(0.903
V).
Theoretical
calculations
indicate
excellent
activity
Zn
can
be
attributed
integration
atoms
effectively
optimizes
rate-limiting
step.
also
presents
robust
durability
strong
methanol
tolerance.
Moreover,
ZAB
assembled
with
delivers
charge–discharge
cycling
life
(550
h)
at
10
mA
cm–2
without
noticeable
decay.
Furthermore,
even
show
glorious
flexible
adaptability
when
employed
as
cathode
ZAB.
Molecules,
Год журнала:
2024,
Номер
29(11), С. 2643 - 2643
Опубликована: Июнь 4, 2024
Oridonin
(Ori)
is
a
naturally
existing
diterpenoid
substance
that
mainly
exists
in
the
Chinese
medicinal
plant
Rabdosia
rubescens.
It
was
previously
found
to
possess
intriguing
biological
properties;
however,
quick
clearance
from
plasma
and
limited
solubility
water
restricts
its
use
as
drug.
Several
metal–organic
frameworks
(MOFs),
having
big
surfaces
large
pores,
have
recently
been
considered
promising
drug
transporters.
The
zeolitic
imidazolate
framework-8
(ZIF-8),
form
of
MOF
consisting
2-methylimidazole
with
zinc
ions,
structurally
stable
under
physiologically
neutral
conditions,
while
it
can
degrade
at
low
pH
values
such
tumor
cells.
Herein,
nanosized
delivery
system,
Ori@ZIF-8,
successfully
designed
for
encapsulating
transporting
oridonin
site.
loading
prepared
Ori@ZIF-8
26.78%,
particles’
mean
size
240.5
nm.
In
vitro,
release
exhibited
acid
sensitivity,
slow
conditions
rapid
weakly
acidic
conditions.
According
vitro
anti-tumor
experiments,
produced
higher
cytotoxicity
than
free
Ori
induced
apoptosis
A549
cancer
conclusion,
could
be
potential
pH-responsive
carrier
accurately
more
oridonins
