Graphene Quantum Dot Sensitized Heterojunctions Induce Tumor‐Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced Cancer Immunotherapy DOI Creative Commons
Lang Yan, Liang Chang, Yijun Tian

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Cuproptosis that utilizes copper ionophore to induce programmed cell death holds promise for enhancing the effectiveness of conventional anticancer therapies and triggering efficient adaptive immune responses. However, non-tumor-specific release Cu ions can cuproptosis cause irreversible damage normal tissues. To maximize therapeutic effects tumor-specific cuproptosis, this work reports first time regulation degradation behaviors Cu-based nanomaterials using graphene quantum dots (GQDs) as a protection layer. The deposition GQDs not only avoids

Language: Английский

Copper‐Based Composites Nanoparticles Improve Triple‐Negative Breast Cancer Treatment with Induction of Apoptosis‐Cuproptosis and Immune Activation DOI
Ning Wang, Yichao Liu,

Dezhou Peng

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: July 12, 2024

The synergistic effect of apoptosis and cuproptosis, along with the activation immune system, presents a promising approach to enhance efficacy against triple-negative breast cancer (TNBC). Here, two prodrugs are synthesized: reactive oxygen species (ROS)-responsive prodrug PEG-TK-DOX glutathione (GSH)-responsive PEG-DTPA-SS-CPT. These self-assembled chelated Cu2+ prepare nanoparticle PCD@Cu that simultaneously loaded doxorubicin (DOX), camptothecin (CPT), Cu2+. elevated levels ROS GSH in TNBC cells disrupted structure, leading release Cu+, DOX, CPT depletion GSH. DOX triggered immunogenic cell death (ICD) cells. Simultaneously, downregulated expression copper transporting ATPase 2 (ATP7B), causing significant accumulation ions This further induced aggregation lipoylated dihydrolipoamide S-acetyltransferase (DLAT) downregulation iron-sulfur (Fe-S) cluster proteins, ultimately cuproptosis ICD TNBC. In vitro vivo experiments confirmed activated demonstrating strong anti-tumor capabilities. Moreover, exhibited an excellent biosafety profile. Overall, this study provides strategy for effective therapy.

Language: Английский

Citations

18
Composite bioreactor for synergistic Modulation of tumor microenvironment and endogenous Regulation of ROS generation to enhance chemodynamic therapy for lung cancer DOI

Longhao Lv,

Yong Liu, Chengsong Cao

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 683, P. 918 - 929

Published: Jan. 4, 2025

Language: Английский

Citations

1
Carbon dot decorated covalent organic framework for mild NIR-II photothermal and heterojunction amplified sonodynamic and chemodynamic therapy DOI
Yanqun Pan,

Lingling Fang,

S.H. Gu

et al.

Carbon, Journal Year: 2025, Volume and Issue: unknown, P. 119987 - 119987

Published: Jan. 1, 2025

Language: Английский

Citations

1
Defect Engineering of Biodegradable Sulfide Nanocage Sonozyme Systems Enables Robust Immunotherapy Against Metastatic Cancers DOI
Jinming Cai,

Qianwen Shen,

Yue Wu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Abstract It is important but challenging to innovate inorganic sonosensitizers with controlled biodegradability and enhanced sonodynamic chemodynamic activities harness remodel the immunosuppressive tumor microenvironment (TME) for awakening robust immune responses against metastatic cancers. Herein rational design defect engineering strategy of a pH‐responsive biodegradable sonozyme system in sulfide nanocages augmented cancer immunotherapy reported. A series highly defective Co 9 S 8‐x elevated sulfur‐vacancy (V ) levels are fabricated systematically explore V ‐dependent properties by regulating weight ratio sulfur cobalt source. The bandgap substantially reduced from 2.06 1.54 eV, atomic 2+ 3+ increased 1.53 1.97. Therefore, sonodynamic, chemodynamic, antitumor dramatically system. slow degradation slightly acid TME size targeting infiltration, while exerting slight influence on performance. As result, satisfactory therapeutic effects eradication primary, distant, tumors can be achieved. This work highlights potential strategies combating

Language: Английский

Citations

5
In situ construction of heterojunctions to regulate the biodegradation behavior of copper carriers for tumor-specific cuproptosis-enhanced sono-immunotherapy DOI Creative Commons
X. P. Cao,

Lingwei Mao,

Yijun Tian

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 25, 2025

Cuproptosis, a novel approach utilizing copper carriers to trigger programmed cell death, exhibits promise for enhancing traditional therapies and activating robust adaptive immune responses. However, the uncontrolled release of Cu ions risks triggering cuproptosis in healthy tissues, potentially causing irreversible damage. To address this, we report on use Cu-MOF (copper metal-organic framework) protective layer regulate biodegradation copper-based nanomaterials. In situ formation Cu2O nanocubes not only stabilizes material under physiological conditions but also enhances its sonodynamic therapy (SDT) capabilities by establishing Z-Scheme heterojunction. Upon SDT activation, targeted ion at tumor site triggers cascade reactions, generating reactive oxygen species (ROS) via Fenton-like processes depleting glutathione (GSH). This ROS surge, combined with effective cuproptosis, modulates immunosuppressive microenvironment, inducing immunogenic death eliminate primary tumors inhibit metastasis. study offers new paradigm controlled integration SDT, chemodynamic (CDT), immunotherapy, achieving precise tumor-targeted treatment nanomaterial degradation.

Language: Английский

Citations

0
Tumor Microenvironment Activated Cu Crosslinked Near‐Infrared Sonosensitizers for Visualized Cuproptosis‐Enhanced Sonodynamic Cancer Immunotherapy DOI Creative Commons
Jinyan Hu, Lang Yan, Zhi Cao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Abstract Reactive oxygen species (ROS)‐mediated sonodynamic therapy (SDT) holds increasing potential in treating deep‐seated tumor owing to the high tissue‐penetration depth. However, inevitable accumulation of sonosensitizers normal tissues not only make it difficult realize situ SDT, but also induces effects tissues. Herein, this work reports passivation and selective activation strategies for near‐infrared (NIR) imaging performances an intelligent antitumor theranostic platform termed Cu‐IR783 nanoparticles (NPs). Owing ruptured coordination bond between IR783 with Cu ions by responding microenvironment (TME), occurred achieve visualized in‐situ SDT. The tumor‐specific released realized cascade amplification ROS generation through + ‐mediated Fenton‐like reaction, triggered cuproptosis ‐induced DLAT oligomerization mitochondrial dysfunction. More importantly, immunosuppressive TME can be reversed greatly enhanced levels high‐efficiency cuproptosis, ultimately inducing immunogenic cell death that promotes robust systemic immune responses eradication primary tumors suppression distant tumors. This provides a distinct paradigm integration CDT, controlled manner therapy.

Language: Английский

Citations

1
Tumor microenvironment activated MXene-protected Cu2O heterojunctions induce tumor-specific cuproptosis for enhanced sono-immunotherapy DOI

Panfeng Wang,

Lijun Ren, Yifan Tang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156753 - 156753

Published: Oct. 1, 2024

Language: Английский

Citations

1
Progress in application of nanomedicines for enhancing cancer sono-immunotherapy DOI Creative Commons

Hongxin Zhao,

Fangxue Du,

Xiang Xi

et al.

Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 111, P. 107105 - 107105

Published: Oct. 15, 2024

Language: Английский

Citations

0
Graphene Quantum Dot Sensitized Heterojunctions Induce Tumor‐Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced Cancer Immunotherapy DOI Creative Commons
Lang Yan, Liang Chang, Yijun Tian

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Cuproptosis that utilizes copper ionophore to induce programmed cell death holds promise for enhancing the effectiveness of conventional anticancer therapies and triggering efficient adaptive immune responses. However, non-tumor-specific release Cu ions can cuproptosis cause irreversible damage normal tissues. To maximize therapeutic effects tumor-specific cuproptosis, this work reports first time regulation degradation behaviors Cu-based nanomaterials using graphene quantum dots (GQDs) as a protection layer. The deposition GQDs not only avoids

Language: Английский

Citations

0