Food Chemistry, Год журнала: 2025, Номер unknown, С. 144178 - 144178
Опубликована: Апрель 1, 2025
Язык: Английский
Cellular and Molecular Life Sciences, Год журнала: 2020, Номер 77(22), С. 4523 - 4551
Опубликована: Май 24, 2020
Organisms adapt to changing environments by adjusting their development, metabolism, and behavior improve chances of survival reproduction. To achieve such flexibility, organisms must be able sense respond changes in external environmental conditions internal state. Metabolic adaptation response altered nutrient availability is key maintaining energy homeostasis sustaining developmental growth. Furthermore, variables exert major influences on growth final adult body size animals. This plasticity depends adaptive responses state cues that are essential for processes. Genetic studies have shown the fruit fly Drosophila, similarly mammals, regulates its growth, environment through several hormones including insulin, peptides with glucagon-like function, steroid hormones. Here we review emerging evidence showing various sensed different organs that, via inter-organ communication, relay information neuroendocrine centers control insulin signaling. focuses endocrine regulation highlighting recent advances role system as a signaling hub integrates inputs drives responses.
Язык: Английский
Процитировано
131
Nature Communications, Год журнала: 2021, Номер 12(1)
Опубликована: Авг. 10, 2021
Abstract The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the secretion of glucagon and insulins mammals. Although glucagon-like insulin-like hormones have been found across animal phyla, incretin-like EEC-derived not yet characterised invertebrates. Here, we show that midgut-derived hormone, neuropeptide F (NPF), acts as sugar-responsive, hormone fruit fly, Drosophila melanogaster . Secreted NPF is received by receptor corpora cardiaca insulin-producing cells. NPF-NPFR signalling resulted suppression production enhancement peptide secretion, eventually promoting lipid anabolism. Similar to loss incretin function mammals, midgut led significant metabolic dysfunction, accompanied lipodystrophy, hyperphagia, hypoglycaemia. These results suggest regulate sugar-dependent metabolism through only mammals but also insects.
Язык: Английский
Процитировано
97
Cell and Tissue Research, Год журнала: 2020, Номер 382(2), С. 233 - 266
Опубликована: Авг. 22, 2020
Hormones regulate development, as well many vital processes in the daily life of an animal. Many these hormones are peptides that act at a higher hierarchical level animal with roles organizers globally orchestrate metabolism, physiology and behavior. Peptide can on multiple peripheral targets simultaneously convey basal states, such metabolic status sleep-awake or arousal across central neuronal circuits. Thereby, they coordinate responses to changing internal external environments. The activity neurosecretory cells is controlled either by (1) cell autonomous sensors, (2) other neurons relay signals from sensors tissues (3) feedback target cells. Thus, hormonal signaling axis commonly comprises several components. In mammals vertebrates, axes known, hypothalamic-pituitary-gonad hypothalamic-pituitary-thyroid reproduction respectively. It has been proposed basic organization evolutionarily old cellular homologs hypothalamic-pituitary system be found for instance insects. To obtain appreciation similarities between insect vertebrate axes, we review systems Drosophila. Our outlines major peptidergic pathways known Drosophila presents set schemes orchestrating systems. detailed larval adult displays only very those arthropods vertebrates.
Язык: Английский
Процитировано
89
Journal of Experimental Biology, Год журнала: 2020, Номер 223(7)
Опубликована: Апрель 1, 2020
ABSTRACT Octopamine (OA) and tyramine (TA) are closely related biogenic monoamines that act as signalling compounds in invertebrates, where they fulfil the roles played by adrenaline noradrenaline vertebrates. Just like noradrenaline, OA TA extremely pleiotropic substances regulate a wide variety of processes, including metabolic pathways. However, role metabolism has been largely neglected. The principal aim this Review is to discuss control processes invertebrate species. essential aspects energy homeostasis having substantial effects on both uptake expenditure. These two several different factors, such rate, physical activity, feeding rate or food choice have considerable influence effective intake all contributors consumption. Thereby, activity. should not be seen isolated actions these neuroactive but part comprehensive regulatory system allows organism switch from one physiological state another.
Язык: Английский
Процитировано
81
Cell Metabolism, Год журнала: 2021, Номер 33(7), С. 1279 - 1292
Опубликована: Июнь 16, 2021
Язык: Английский
Процитировано
68
Frontiers in Physiology, Год журнала: 2021, Номер 12
Опубликована: Июнь 29, 2021
The insulin-like peptide (ILP) and growth factor (IGF) signalling pathways play a crucial role in the regulation of metabolism, development, fecundity, stress resistance, lifespan. ILPs are encoded by multigene families that expressed nervous non-nervous organs, including midgut, salivary glands, fat body, tissue- stage-specific manner. Thus, more multidirectional complex control insect metabolism can occur. not only factors regulate metabolism. interact many cross-talk interactions different factors, for example, hormones (peptide nonpeptide), neurotransmitters factors. These observed at levels, three appear to be most prominent/significant: (1) coinfluence other on same target cells, (2) influence synthesis/secretion regulating (3) activity cells producing/secreting various For brain insulin-producing co-express sulfakinins (SKs), which cholecystokinin-like peptides, another key regulator express receptors tachykinin-related next involved It was also shown Drosophila melanogaster directly indirectly AKH. This review presents an overview regulatory peptides how these with players its regulation.
Язык: Английский
Процитировано
67
Neuron, Год журнала: 2022, Номер 110(6), С. 1036 - 1050.e7
Опубликована: Янв. 19, 2022
The nervous and endocrine systems coordinately monitor regulate nutrient availability to maintain energy homeostasis. Sensory detection of food regulates internal in a manner that anticipates intake, but sensory pathways promote anticipatory physiological changes remain unclear. Here, we identify serotonergic (5-HT) neurons as critical mediators transform gustatory by into the activation insulin-producing cells enteric Drosophila. One class 5-HT responds sugars, excites cells, limits consumption, suggesting they anticipate increased levels prevent overconsumption. A second bitter compounds activates gastric motility, likely stimulate digestion increase circulating nutrients upon rejection. These studies demonstrate relay acute divergent for longer-term stabilization nutrients.
Язык: Английский
Процитировано
43
Molecular and Cellular Endocrinology, Год журнала: 2024, Номер 584, С. 112165 - 112165
Опубликована: Янв. 23, 2024
Язык: Английский
Процитировано
10
Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 108179 - 108179
Опубликована: Янв. 1, 2025
Highlights:•The fat body undergoes lipophagy during insect metamorphosis.•The steroid hormone 20E upregulates Akh and Akhr expression.•The AKH pathway increases hemolymph glucose levels by promoting gluconeogenesis.•High promote FOXO acetylation nuclear localization to induce gene expression of lipophagy.AbstractLipophagy is a way degrade lipids; however, the molecular mechanisms are not fully understood. Using holometabolous lepidopteran Helicoverpa armigera, cotton bollworm, as model, we revealed that larval metamorphosis, essential for metamorphosis. The 20-hydroxyecdysone (20E) induced peptide adipokinetic (AKH, analog glucagon) receptor (AKHR). was highly expressed in brain various tissues. upregulated its EcR AKHR increased via gluconeogenesis promoted lipophagy. high level lipases autophagy genes. Thus, brain-adipose tissue axis pathway, which presented nutrients energy pupal adult development metamorphosis after feeding stops.
Язык: Английский
Процитировано
2
Scientific Reports, Год журнала: 2018, Номер 8(1)
Опубликована: Янв. 26, 2018
Abstract In response to adverse environmental conditions many organisms from nematodes mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense growth reproduction. Dormancy regulation has been studied in C. elegans several insects, but how neurosensory mechanisms act relay cues endocrine system order induce remains unclear. Here we examine this fundamental question by genetically manipulating aminergic neurotransmitter signaling Drosophila melanogaster . We find both serotonin dopamine adult ovarian dormancy, while downregulation their respective pathways cells tissues (insulin producing cells, fat body, corpus allatum ) reduces dormancy. contrast, octopamine antagonizes Our findings our understanding cope with unfavorable environments illuminate some relevant pathways.
Язык: Английский
Процитировано
66