The steroid hormone 20-hydroxyecdysone induces lipophagy via the brain-adipose tissue axis by promoting the adipokinetic hormone pathway

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108179 - 108179

Published: Jan. 1, 2025

Highlights:•The fat body undergoes lipophagy during insect metamorphosis.•The steroid hormone 20E upregulates Akh and Akhr expression.•The AKH pathway increases hemolymph glucose levels by promoting gluconeogenesis.•High promote FOXO acetylation nuclear localization to induce gene expression of lipophagy.AbstractLipophagy is a way degrade lipids; however, the molecular mechanisms are not fully understood. Using holometabolous lepidopteran Helicoverpa armigera, cotton bollworm, as model, we revealed that larval metamorphosis, essential for metamorphosis. The 20-hydroxyecdysone (20E) induced peptide adipokinetic (AKH, analog glucagon) receptor (AKHR). was highly expressed in brain various tissues. upregulated its EcR AKHR increased via gluconeogenesis promoted lipophagy. high level lipases autophagy genes. Thus, brain-adipose tissue axis pathway, which presented nutrients energy pupal adult development metamorphosis after feeding stops.

Language: Английский

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Metabolism and growth adaptation to environmental conditions in Drosophila

Cellular and Molecular Life Sciences, Journal Year: 2020, Volume and Issue: 77(22), P. 4523 - 4551

Published: May 24, 2020

Organisms adapt to changing environments by adjusting their development, metabolism, and behavior improve chances of survival reproduction. To achieve such flexibility, organisms must be able sense respond changes in external environmental conditions internal state. Metabolic adaptation response altered nutrient availability is key maintaining energy homeostasis sustaining developmental growth. Furthermore, variables exert major influences on growth final adult body size animals. This plasticity depends adaptive responses state cues that are essential for processes. Genetic studies have shown the fruit fly Drosophila, similarly mammals, regulates its growth, environment through several hormones including insulin, peptides with glucagon-like function, steroid hormones. Here we review emerging evidence showing various sensed different organs that, via inter-organ communication, relay information neuroendocrine centers control insulin signaling. focuses endocrine regulation highlighting recent advances role system as a signaling hub integrates inputs drives responses.

Language: Английский

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The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Aug. 10, 2021

Abstract The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the secretion of glucagon and insulins mammals. Although glucagon-like insulin-like hormones have been found across animal phyla, incretin-like EEC-derived not yet characterised invertebrates. Here, we show that midgut-derived hormone, neuropeptide F (NPF), acts as sugar-responsive, hormone fruit fly, Drosophila melanogaster . Secreted NPF is received by receptor corpora cardiaca insulin-producing cells. NPF-NPFR signalling resulted suppression production enhancement peptide secretion, eventually promoting lipid anabolism. Similar to loss incretin function mammals, midgut led significant metabolic dysfunction, accompanied lipodystrophy, hyperphagia, hypoglycaemia. These results suggest regulate sugar-dependent metabolism through only mammals but also insects.

Language: Английский

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Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions

Cell and Tissue Research, Journal Year: 2020, Volume and Issue: 382(2), P. 233 - 266

Published: Aug. 22, 2020

Hormones regulate development, as well many vital processes in the daily life of an animal. Many these hormones are peptides that act at a higher hierarchical level animal with roles organizers globally orchestrate metabolism, physiology and behavior. Peptide can on multiple peripheral targets simultaneously convey basal states, such metabolic status sleep-awake or arousal across central neuronal circuits. Thereby, they coordinate responses to changing internal external environments. The activity neurosecretory cells is controlled either by (1) cell autonomous sensors, (2) other neurons relay signals from sensors tissues (3) feedback target cells. Thus, hormonal signaling axis commonly comprises several components. In mammals vertebrates, axes known, hypothalamic-pituitary-gonad hypothalamic-pituitary-thyroid reproduction respectively. It has been proposed basic organization evolutionarily old cellular homologs hypothalamic-pituitary system be found for instance insects. To obtain appreciation similarities between insect vertebrate axes, we review systems Drosophila. Our outlines major peptidergic pathways known Drosophila presents set schemes orchestrating systems. detailed larval adult displays only very those arthropods vertebrates.

Language: Английский

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The control of metabolic traits by octopamine and tyramine in invertebrates

Journal of Experimental Biology, Journal Year: 2020, Volume and Issue: 223(7)

Published: April 1, 2020

ABSTRACT Octopamine (OA) and tyramine (TA) are closely related biogenic monoamines that act as signalling compounds in invertebrates, where they fulfil the roles played by adrenaline noradrenaline vertebrates. Just like noradrenaline, OA TA extremely pleiotropic substances regulate a wide variety of processes, including metabolic pathways. However, role metabolism has been largely neglected. The principal aim this Review is to discuss control processes invertebrate species. essential aspects energy homeostasis having substantial effects on both uptake expenditure. These two several different factors, such rate, physical activity, feeding rate or food choice have considerable influence effective intake all contributors consumption. Thereby, activity. should not be seen isolated actions these neuroactive but part comprehensive regulatory system allows organism switch from one physiological state another.

Language: Английский

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Insulin-Like Peptides and Cross-Talk With Other Factors in the Regulation of Insect Metabolism

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: June 29, 2021

The insulin-like peptide (ILP) and growth factor (IGF) signalling pathways play a crucial role in the regulation of metabolism, development, fecundity, stress resistance, lifespan. ILPs are encoded by multigene families that expressed nervous non-nervous organs, including midgut, salivary glands, fat body, tissue- stage-specific manner. Thus, more multidirectional complex control insect metabolism can occur. not only factors regulate metabolism. interact many cross-talk interactions different factors, for example, hormones (peptide nonpeptide), neurotransmitters factors. These observed at levels, three appear to be most prominent/significant: (1) coinfluence other on same target cells, (2) influence synthesis/secretion regulating (3) activity cells producing/secreting various For brain insulin-producing co-express sulfakinins (SKs), which cholecystokinin-like peptides, another key regulator express receptors tachykinin-related next involved It was also shown Drosophila melanogaster directly indirectly AKH. This review presents an overview regulatory peptides how these with players its regulation.

Language: Английский

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Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(7), P. 1279 - 1292

Published: June 16, 2021

Language: Английский

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Serotonergic neurons translate taste detection into internal nutrient regulation

Neuron, Journal Year: 2022, Volume and Issue: 110(6), P. 1036 - 1050.e7

Published: Jan. 19, 2022

The nervous and endocrine systems coordinately monitor regulate nutrient availability to maintain energy homeostasis. Sensory detection of food regulates internal in a manner that anticipates intake, but sensory pathways promote anticipatory physiological changes remain unclear. Here, we identify serotonergic (5-HT) neurons as critical mediators transform gustatory by into the activation insulin-producing cells enteric Drosophila. One class 5-HT responds sugars, excites cells, limits consumption, suggesting they anticipate increased levels prevent overconsumption. A second bitter compounds activates gastric motility, likely stimulate digestion increase circulating nutrients upon rejection. These studies demonstrate relay acute divergent for longer-term stabilization nutrients.

Language: Английский

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Leptin- and cytokine-like unpaired signaling in Drosophila

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 584, P. 112165 - 112165

Published: Jan. 23, 2024

Language: Английский

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Aminergic Signaling Controls Ovarian Dormancy in Drosophila

Scientific Reports, Journal Year: 2018, Volume and Issue: 8(1)

Published: Jan. 26, 2018

Abstract In response to adverse environmental conditions many organisms from nematodes mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense growth reproduction. Dormancy regulation has been studied in C. elegans several insects, but how neurosensory mechanisms act relay cues endocrine system order induce remains unclear. Here we examine this fundamental question by genetically manipulating aminergic neurotransmitter signaling Drosophila melanogaster . We find both serotonin dopamine adult ovarian dormancy, while downregulation their respective pathways cells tissues (insulin producing cells, fat body, corpus allatum ) reduces dormancy. contrast, octopamine antagonizes Our findings our understanding cope with unfavorable environments illuminate some relevant pathways.

Language: Английский

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