Navigating the Complex Intersection of Substance Use and Psychiatric Disorders: A Comprehensive Review

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(4), С. 999 - 999

Опубликована: Фев. 9, 2024

The co-occurrence of substance use disorders (SUDs) and psychiatric conditions, often referred to as comorbidity or concurrent disorders, presents intricate challenges in both diagnosis treatment. This comprehensive narrative review aims synthesize critically evaluate the existing evidence surrounding management individuals with comorbid SUDs disorders. Comorbidity these domains carries profound implications for clinical practice, research, policymaking, emphasizing need a holistic understanding dynamics that arise when conditions coexist. explores recent research findings, evidence-based guidelines, emerging trends within field, offering valuable insights clinicians, researchers, policymakers seeking navigate complex terrain

Язык: Английский

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Artificial intelligence significantly facilitates development in the mental health of college students: a bibliometric analysis

Frontiers in Psychology, Год журнала: 2024, Номер 15

Опубликована: Март 7, 2024

Objective College students are currently grappling with severe mental health challenges, and research on artificial intelligence (AI) related to college health, as a crucial catalyst for promoting psychological well-being, is rapidly advancing. Employing bibliometric methods, this study aim analyze discuss the AI in student health. Methods Publications pertaining were retrieved from Web of Science core database. The distribution publications analyzed gage predominant productivity. Data countries, authors, journal, keywords using VOSViewer, exploring collaboration patterns, disciplinary composition, hotspots trends. Results Spanning 2003 2023, encompassed 1722 publications, revealing notable insights: (1) gradual rise annual reaching its zenith 2022; (2) Journal Affective Disorders Psychiatry Research emerged most productive influential sources field, significant contributions China, United States, their affiliated higher education institutions; (3) primary issues depression anxiety, machine learning having widest range applications; (4) an imperative enhanced international interdisciplinary collaboration; (5) factors influencing applications. Conclusion This provides succinct yet comprehensive overview facilitating nuanced understanding prospective applications Professionals can leverage discern advantages, risks, potential impacts critical field.

Язык: Английский

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Critical review of self‐diagnosis of mental health conditions using artificial intelligence

International Journal of Mental Health Nursing, Год журнала: 2024, Номер 33(2), С. 344 - 358

Опубликована: Фев. 12, 2024

Abstract The advent of artificial intelligence (AI) has revolutionised various aspects our lives, including mental health nursing. AI‐driven tools and applications have provided a convenient accessible means for individuals to assess their well‐being within the confines homes. Nonetheless, widespread trend self‐diagnosing conditions through AI poses considerable risks. This review article examines perils associated with relying on self‐diagnosis in health, highlighting constraints possible adverse outcomes that can arise from such practices. It delves into ethical, psychological, social implications, underscoring vital role professionals, psychologists, psychiatrists, nursing specialists, providing professional assistance guidance. aims highlight importance seeking guidance addressing concerns, especially era self‐diagnosis.

Язык: Английский

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Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 172, С. 116267 - 116267

Опубликована: Фев. 16, 2024

Schizophrenia (SCZ) is a psychotic mental disorder characterized by cognitive, behavioral, and social impairments. However, current pharmacological treatment regimens are subpar in terms of effectiveness. This study aimed to investigate the function Radix Bupleuri aqueous extract SCZ mouse models. The model was established MK-801 injection feeding or combined antibiotics. significantly improved aberrant behaviors neuronal damage mice, upregulated SYP PSD-95 expression BDNF levels hippocampal homogenates, down-regulated DA 5-HT levels, suppressed microglial activation mice. Moreover, integrity intestinal tract barrier. 16 S rRNA sequencing feces showed that modulated composition gut flora. Lactobacillus abundance decreased mice reversed administration which exhibited significant negative correlation with IL-6, IL-1β, DA, 5-HT, positive tissues. Parabacteroides Alloprevotella increased It administration, BDNF. In conclusion, attenuates inflammatory response tissues modulates neurotransmitter exerting its neuroprotective effect SCZ. Meanwhile, alteration flora may be involved this process, expected an underlying therapeutic option treating

Язык: Английский

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New diagnosis in psychiatry: beyond heuristics

Psychological Medicine, Год журнала: 2025, Номер 55

Опубликована: Янв. 1, 2025

Abstract Background Diagnosis in psychiatry faces familiar challenges. Validity and utility remain elusive, confusion regarding the fluid arbitrary border between mental health illness is increasing. The mainstream strategy has been conservative iterative, retaining current nosology until something better emerges. However, this led to stagnation. New conceptual frameworks are urgently required catalyze a genuine paradigm shift. Methods We outline candidate strategies that could pave way for such These include Research Domain Criteria (RDoC), Hierarchical Taxonomy of Psychopathology (HiTOP), Clinical Staging, which all promote blend dimensional categorical approaches. Results alternative still heuristic transdiagnostic models provide varying levels clinical research utility. RDoC was intended framework reorient beyond constraints DSM. HiTOP began as derived from statistical methods now pursuing Staging aims both expand scope refine diagnosis by inclusion dimension timing. None yet fit purpose. Yet they relatively complementary, it may be possible them operate an ecosystem. Time will tell whether have capacity singly or jointly deliver Conclusions Several developed separately synergistically build infrastructure enable new define structure, development, mechanisms disorders, guide treatment meet needs patients, policymakers, society.

Язык: Английский

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Research Domain Criteria in NIMH Grants Characterized Using Large Language Models

JAMA Network Open, Год журнала: 2025, Номер 8(2), С. e2459371 - e2459371

Опубликована: Фев. 12, 2025

Importance Over the past decade, leadership of National Institute Mental Health (NIMH) has emphasized importance a transdiagnostic approach to psychiatric investigation using Research Domain Criteria (RDoC) mapping more closely neurobiology. Objective To investigate whether research support from NIMH for individual RDoC domains and changed over time had differential impact in terms publication, citations, or patent filings. Design, Setting, Participants In this longitudinal cohort study, all R01, R21, R03 studies funded by between January 2003 December 2023 were identified via Institutes RePORTER database. Their abstracts characterized (negative valence, positive cognition, social, arousal, sensorimotor) large language model. Main Outcomes Measures Primary outcomes publications, citation estimated at 5 years index year funding, patents, examined regression models adjusted other grant characteristics. Results Among 8897 R03, R21 projects, reflecting $17.7 billion investment, 3141 (35.3%) reflected negative valence; 1344 (15.1%), 2781 (31.3%), cognition; 1607 (18.1%), social; 343 (3.9%), arousal; 571 (6.4%), sensorimotor domains. A total 1793 (20.2%) incorporated perspective. Positive social associated with fewer publications (difference, −1.13 [95% CI, −2.11 −0.15] −2.23 −3.15 −1.30], respectively) lesser −0.47 −0.75 −0.18] −1.19 −1.46 −0.91], years. Social (adjusted odds ratio [AOR], 0.11; 95% 0.04-0.23) cognitive (AOR, 0.66; 0.48-0.89) proposals 0.37; 0.21-0.60) lower likelihood filing. Conclusions Relevance study grants different differed substantially their scientific generation. The findings suggest that represent promising characterizing scale, which may be useful guiding resource allocation maximize return on investment.

Язык: Английский

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Data sharing in child and adolescent psychiatry research: Key challenges (and some potential solutions)

Open Research Europe, Год журнала: 2025, Номер 5, С. 93 - 93

Опубликована: Март 31, 2025

Background The field of biomedical research is entering a new era, in which public data sharing increasingly the norm. There are many advantages embracing initiatives, including tackling replication crisis through enhanced transparency and publication null findings, facilitating global collaborations to accelerate progress, enhancing cost-effectiveness by reducing duplication efforts, making scientific advances more accessible public. However, there also several crucial ethical logistical challenges that must be addressed maximise benefits minimise risks. potential, recognised, risks unregulated (e.g., reidentification, misuse, lack representativeness due variability who agrees share data) have been exemplified high profile breaches directly clash with efforts make robust, accessible, global. Methods/Results Here, we narratively outline current for from perspective child adolescent psychiatry, one area where they may particularly acute. For example, early often requires caregivers consent on behalf minor – increasing responsibility researchers consider how science today evolve into future (when those individuals no longer minors). We use our consortium Autism Innovative Medicines Study - 2 Trials (AIMS-2-TRIALS; https://www.aims-2-trials.eu/) illustrate points raised this piece. Conclusions propose some potential solutions begin address sharing, focusing key priorities, shared control curation between researcher participant communities equity access groups tools resources needed conduct responsible sustainable sharing.

Язык: Английский

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Systems‐based approaches to mental disorders are the only game in town

World Psychiatry, Год журнала: 2022, Номер 21(3), С. 420 - 422

Опубликована: Сен. 8, 2022

Язык: Английский

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Anxious, Depressed, and Suicidal: Crisis Narratives in University Student Mental Health and the Need for a Balanced Approach to Student Wellness

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(6), С. 4859 - 4859

Опубликована: Март 9, 2023

There is growing global awareness of the poor mental health university students, as well need to improve students’ access services and expand range available evidence-based interventions. However, a crisis narrative emerging, particularly in wake COVID-19 pandemic, that runs risk positioning all students potential patients formal psychiatric Our aim this commentary critically present evidence supports increased attention student health, while also raising concern may itself have unintended harmful consequences. We highlight some dangers overtly medicalizing thus pathologizing experiences everyday distress, inadequacies diagnostic categories, limitations focusing narrowly on psychotherapeutic interventions, short-sightedness downplaying key social determinants distress. argue for an integrative balanced public approach draws rigor epidemiology advances been made identify interventions simultaneously being mindful shortcomings working within paradigm labels

Язык: Английский

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The Involvement of Service Users and People With Lived Experience in Mental Health Care Innovation Through Design: Systematic Review

JMIR Mental Health, Год журнала: 2023, Номер 10, С. e46590 - e46590

Опубликована: Июнь 17, 2023

Mental health care faces challenges that not only necessitate innovation but also require the involvement of service users and people with lived experience in developing evaluating mental services. As development digital interventions is becoming more prevalent, design approaches are increasingly finding their way into health. There evidence these can successfully integrate user However, there no clear overview studies conducted lessons learned concerning experience.In this systematic review, we aimed to provide an services through synthesize advantages care.The following 5 databases were searched for relevant abstracts: PsycINFO, PubMed, Web Science, Scopus, Embase. In addition, 2 journal archives, Design Health The Journal Design, searched. To categorize results, collected reported added value from included articles a thematic synthesis which themes developed retrieved data. discussed, revised, checked until saturation was achieved.We categorized 33 papers. Most involved users, primarily adults, used various approaches. or evaluate interventions. Service different roles never as decision makers. Studies co-design exhibited highest levels involvement. Various values reported, including tailoring testing interventions, improving engagement collaboration, gathering needs stakeholders, empowering participants resourceful actors. maintaining participants' continued participation throughout study, managing iterative nature design, providing safe space, balancing insights medical science, navigating processes environments.This review provides involve innovation. have innovation, offering having manageable challenges. Future using should partners makers report on collaboration manner.

Язык: Английский

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