Journal of Neuroinflammation,
Год журнала:
2023,
Номер
20(1)
Опубликована: Июль 23, 2023
Abstract
Neuroinflammation
has
been
implicated
in
the
initiation
and
progression
of
several
central
nervous
system
(CNS)
disorders,
including
Alzheimer’s
disease,
Parkinson’s
amyotrophic
lateral
sclerosis,
multiple
ischemic
stroke,
traumatic
brain
injury,
spinal
cord
viral
encephalitis,
bacterial
encephalitis.
Microglia
astrocytes
are
essential
neural
development,
maintenance
synaptic
connections,
homeostasis
a
healthy
brain.
The
activation
microglia
is
defense
mechanism
against
damaged
tissues
harmful
pathogens.
However,
their
triggers
neuroinflammation,
which
can
exacerbate
or
induce
CNS
injury.
Non-coding
RNAs
(ncRNAs)
functional
RNA
molecules
that
lack
coding
capabilities
but
actively
regulate
mRNA
expression
function
through
various
mechanisms.
ncRNAs
highly
expressed
potential
mediators
neuroinflammation.
We
reviewed
recent
research
progress
on
role
miRNAs,
lncRNAs,
circRNAs
regulating
neuroinflammation
diseases.
Understanding
how
these
affect
will
provide
important
therapeutic
insights
for
preventing
managing
dysfunction.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 16, 2022
Aging
is
a
gradual
and
irreversible
pathophysiological
process.
It
presents
with
declines
in
tissue
cell
functions
significant
increases
the
risks
of
various
aging-related
diseases,
including
neurodegenerative
cardiovascular
metabolic
musculoskeletal
immune
system
diseases.
Although
development
modern
medicine
has
promoted
human
health
greatly
extended
life
expectancy,
aging
society,
variety
chronic
diseases
have
gradually
become
most
important
causes
disability
death
elderly
individuals.
Current
research
on
focuses
elucidating
how
endogenous
exogenous
stresses
(such
as
genomic
instability,
telomere
dysfunction,
epigenetic
alterations,
loss
proteostasis,
compromise
autophagy,
mitochondrial
cellular
senescence,
stem
exhaustion,
altered
intercellular
communication,
deregulated
nutrient
sensing)
participate
regulation
aging.
Furthermore,
thorough
pathogenesis
to
identify
interventions
that
promote
longevity
caloric
restriction,
microbiota
transplantation,
nutritional
intervention)
clinical
treatment
methods
for
(depletion
senescent
cells,
therapy,
antioxidative
anti-inflammatory
treatments,
hormone
replacement
therapy)
could
decrease
incidence
turn
healthy
longevity.
Frontiers in Genetics,
Год журнала:
2019,
Номер
10
Опубликована: Март 1, 2019
Alzheimer's
Disease
(AD)
is
a
progressive
and
devastating
neurodegenerative
disorder.
It
the
leading
cause
of
dementia
in
world's
rapidly
growing
aging
population.
The
characteristics
AD
are
memory
loss
cognitive
impairment,
meaning
patients
cannot
carry
out
their
daily
activities
independently.
increase
cases
poses
heavy
burdens
on
families,
society
economy.
Despite
frequent
efforts
being
made
to
research
etiology
AD,
causes
remain
unknown,
no
curative
treatments
available
yet.
pathological
hallmarks
amyloid
plaques
neurofibrillary
tangles
brain;
microRNAs
endogenous
~22
nucleotides
non-coding
RNAs
that
could
regulate
gene
expression
at
post-transcriptional
level
by
transcript
degradation
or
translation
repression.
involved
many
biological
processes
diseases,
particularly
multifactorial
providing
an
excellent
tool
with
which
mechanisms
these
diseases.
disorder,
accumulating
evidence
shows
play
critical
role
pathogenesis
AD.
In
this
review,
we
will
highlight
effect
different
throughout
progression.
Clinical Anatomy,
Год журнала:
2021,
Номер
35(1), С. 65 - 78
Опубликована: Сен. 24, 2021
Neurodegenerative
disorders
are
characterized
by
progressive
loss
of
particular
populations
neurons.
Apoptosis
has
been
implicated
in
the
pathogenesis
neurodegenerative
diseases,
including
Parkinson
disease,
Alzheimer
Huntington
and
amyotrophic
lateral
sclerosis.
In
this
review,
we
focus
on
existing
notions
relevant
to
comprehending
apoptotic
death
process,
morphological
features,
mediators
regulators
cellular
apoptosis.
We
also
highlight
evidence
neuronal
Additionally,
present
potential
therapeutic
agents
that
could
modify
pathway
aforementioned
diseases
delay
disease
progression.
Finally,
review
clinical
trials
were
conducted
evaluate
use
anti-apoptotic
drugs
treatment
order
essential
need
for
early
detection
intervention
humans.
Molecular Therapy,
Год журнала:
2023,
Номер
31(6), С. 1550 - 1561
Опубликована: Фев. 14, 2023
Investigation
of
lncRNA
functions
in
the
CNS
is
a
rapidly
expanding
field
that
holds
exciting
potential
for
new
advances
understanding
brain
cell
physiology
and
improving
disease
diagnosis
therapy.
This
review
summarizes
important
evidence
regarding
roles
lncRNAs
cellular
molecular
processes,
highlighting
few
have
been
studied
as
biomarkers
disorders
involving
neurodegeneration,
neurodevelopment,
more.
Our
current
fine-tuning
influence
variety
human
diseases
represent
type
molecule
can
be
easily
targeted
with
high
specificity.
However,
direct
involvement
pathologies
has
shown
only
reduced
number
cases.
Given
tissues
exhibit
large
enrichment
diversity
ncRNAs,
future
research
will
key
to
elucidating
known
still
unidentified
CNS,
these
noncodings
serve
diagnostic
even
targets
treatment
conditions.
Translational Neurodegeneration,
Год журнала:
2024,
Номер
13(1)
Опубликована: Янв. 23, 2024
Abstract
Ageing
is
a
crucial
risk
factor
for
Alzheimer’s
disease
(AD)
and
characterised
by
systemic
changes
in
both
intracellular
extracellular
microenvironments
that
affect
the
entire
body
instead
of
single
organ.
Understanding
specific
mechanisms
underlying
role
ageing
development
can
facilitate
treatment
ageing-related
diseases,
such
as
AD.
Signs
brain
have
been
observed
AD
patients
animal
models.
Alleviating
pathological
caused
dramatically
ameliorate
amyloid
beta-
tau-induced
neuropathological
memory
impairments,
indicating
plays
pathophysiological
process
In
this
review,
we
summarize
impact
several
age-related
factors
on
propose
preventing
promising
strategy
improving
cognitive
health.
Acta Neuropathologica,
Год журнала:
2018,
Номер
136(4), С. 537 - 555
Опубликована: Июль 7, 2018
MicroRNAs
(miRNA)
regulate
fundamental
biological
processes,
including
neuronal
plasticity,
stress
response,
and
survival.
Here,
we
describe
a
neuroprotective
function
of
miR-132,
the
miRNA
most
significantly
downregulated
in
neurons
Alzheimer's
disease.
We
demonstrate
that
miR-132
protects
primary
mouse
human
wild-type
more
vulnerable
Tau-mutant
against
amyloid
β-peptide
(Aβ)
glutamate
excitotoxicity.
It
lowers
levels
total,
phosphorylated,
acetylated,
cleaved
forms
Tau
implicated
tauopathies,
promotes
neurite
elongation
branching,
reduces
death.
Similarly,
attenuates
PHF-Tau
pathology
neurodegeneration,
enhances
long-term
potentiation
P301S
transgenic
mice.
The
effects
are
mediated
by
direct
regulation
modifiers
acetyltransferase
EP300,
kinase
GSK3β,
RNA-binding
protein
Rbfox1,
proteases
Calpain
2
Caspases
3/7.
These
data
suggest
as
master
regulator
health
indicate
supplementation
could
be
therapeutic
benefit
for
treatment
Tau-associated
neurodegenerative
disorders.
Nucleic Acids Research,
Год журнала:
2020,
Номер
49(D1), С. D160 - D164
Опубликована: Авг. 14, 2020
Many
studies
have
indicated
that
non-coding
RNA
(ncRNA)
dysfunction
is
closely
related
to
numerous
diseases.
Recently,
accumulated
ncRNA-disease
associations
made
databases
insufficient
meet
the
demands
of
biomedical
research.
The
constant
updating
resources
has
become
essential.
Here,
we
updated
mammal
repository
(MNDR,
http://www.rna-society.org/mndr/)
version
3.0,
containing
more
than
one
million
entries,
four-fold
increment
in
data
compared
previous
version.
Experimental
and
predicted
circRNA-disease
been
integrated,
increasing
number
categories
ncRNAs
five,
mammalian
species
11.
Moreover,
drug
annotations
associations,
as
well
ncRNA
subcellular
localizations
interactions,
were
added.
In
addition,
three
(miRNA/lncRNA/circRNA)
prediction
tools
provided,
website
was
also
optimized,
making
it
practical
user-friendly.
summary,
MNDR
v3.0
will
be
a
valuable
resource
for
investigation
disease
mechanisms
clinical
treatment
strategies.
Yonsei Medical Journal,
Год журнала:
2019,
Номер
60(7), С. 640 - 640
Опубликована: Янв. 1, 2019
Alzheimer's
disease
(AD)
is
the
most
common
neurodegenerative
disease,
with
a
rising
prevalence
worldwide.
Long
noncoding
RNAs
(lncRNAs)
have
been
found
to
play
important
roles
in
development
and
treatment
of
AD.
However,
exact
role
lncRNA
nuclear
enriched
abundant
transcript
1
(NEAT1)
neuronal
damage
AD
largely
unknown.
