Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer’s disease mice model DOI Creative Commons
Haining Liu, Mingming Jin,

Minxiu Ji

et al.

Aging, Journal Year: 2022, Volume and Issue: 14(7), P. 3070 - 3083

Published: April 1, 2022

Alzheimer's disease (AD) is the most common dementia in world. Increasing evidence has shown that exosomes from hypoxic pretreated adipose-derived stem cells (ADSCs) could be an effective cognitive function therapeutic AD-associated pathophysiology. However, their role and regulatory mechanism remain largely unknown. High-throughput sequencing was used to identify differentially expressed circRNAs ADSCs or hypoxia ADSC exosomes. Luciferase reporter assays RT-qPCR were investigate relationships between circ-Epc1, miR-770-3p, TREM2. APP/PS1 double transgenic AD model mice then study effects regarding circ-Epc1 BV2 show TREM2 how these interactions modulated phenotypic transformations inflammatory cytokine expressions microglia. The results showed had a good effect on improving functions by decreasing neuronal damage hippocampus. played important hypoxia-pretreated ability improve functions. miR-770-3p downstream targets of circ-Epc1. Overexpressing downregulating reversed M2 microglia during lipopolysaccharide treatment. In vivo experiments circ-Epc1-containing increased function, damage, shifting hippocampal M1 polarization stages. Taken together, data pretreatment improved cognition delivery microglial M1/M2 mouse model.

Language: Английский

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments DOI Creative Commons
Jun Guo, Xiuqing Huang, Lin Dou

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 16, 2022

Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue cell functions significant increases the risks of various aging-related diseases, including neurodegenerative cardiovascular metabolic musculoskeletal immune system diseases. Although development modern medicine has promoted human health greatly extended life expectancy, aging society, variety chronic diseases have gradually become most important causes disability death elderly individuals. Current research on focuses elucidating how endogenous exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss proteostasis, compromise autophagy, mitochondrial cellular senescence, stem exhaustion, altered intercellular communication, deregulated nutrient sensing) participate regulation aging. Furthermore, thorough pathogenesis to identify interventions that promote longevity caloric restriction, microbiota transplantation, nutritional intervention) clinical treatment methods for (depletion senescent cells, therapy, antioxidative anti-inflammatory treatments, hormone replacement therapy) could decrease incidence turn healthy longevity.

Language: Английский

Citations

773
MicroRNAs in Alzheimer’s Disease DOI Creative Commons
Mengli Wang, Lixia Qin, Beisha Tang

et al.

Frontiers in Genetics, Journal Year: 2019, Volume and Issue: 10

Published: March 1, 2019

Alzheimer's Disease (AD) is a progressive and devastating neurodegenerative disorder. It the leading cause of dementia in world's rapidly growing aging population. The characteristics AD are memory loss cognitive impairment, meaning patients cannot carry out their daily activities independently. increase cases poses heavy burdens on families, society economy. Despite frequent efforts being made to research etiology AD, causes remain unknown, no curative treatments available yet. pathological hallmarks amyloid plaques neurofibrillary tangles brain; microRNAs endogenous ~22 nucleotides non-coding RNAs that could regulate gene expression at post-transcriptional level by transcript degradation or translation repression. involved many biological processes diseases, particularly multifactorial providing an excellent tool with which mechanisms these diseases. disorder, accumulating evidence shows play critical role pathogenesis AD. In this review, we will highlight effect different throughout progression.

Language: Английский

Citations

285
Role of circular RNAs in brain development and CNS diseases DOI

Suresh L. Mehta,

Robert J. Dempsey, Raghu Vemuganti

et al.

Progress in Neurobiology, Journal Year: 2020, Volume and Issue: 186, P. 101746 - 101746

Published: Jan. 10, 2020

Language: Английский

Citations

239
Apoptosis and its therapeutic implications in neurodegenerative diseases DOI
Nour S. Erekat

Clinical Anatomy, Journal Year: 2021, Volume and Issue: 35(1), P. 65 - 78

Published: Sept. 24, 2021

Neurodegenerative disorders are characterized by progressive loss of particular populations neurons. Apoptosis has been implicated in the pathogenesis neurodegenerative diseases, including Parkinson disease, Alzheimer Huntington and amyotrophic lateral sclerosis. In this review, we focus on existing notions relevant to comprehending apoptotic death process, morphological features, mediators regulators cellular apoptosis. We also highlight evidence neuronal Additionally, present potential therapeutic agents that could modify pathway aforementioned diseases delay disease progression. Finally, review clinical trials were conducted evaluate use anti-apoptotic drugs treatment order essential need for early detection intervention humans.

Language: Английский

Citations

121
Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities DOI Creative Commons
Tara Srinivas, Carolina Mathias, Cristina Oliveira-Mateos

et al.

Molecular Therapy, Journal Year: 2023, Volume and Issue: 31(6), P. 1550 - 1561

Published: Feb. 14, 2023

Investigation of lncRNA functions in the CNS is a rapidly expanding field that holds exciting potential for new advances understanding brain cell physiology and improving disease diagnosis therapy. This review summarizes important evidence regarding roles lncRNAs cellular molecular processes, highlighting few have been studied as biomarkers disorders involving neurodegeneration, neurodevelopment, more. Our current fine-tuning influence variety human diseases represent type molecule can be easily targeted with high specificity. However, direct involvement pathologies has shown only reduced number cases. Given tissues exhibit large enrichment diversity ncRNAs, future research will key to elucidating known still unidentified CNS, these noncodings serve diagnostic even targets treatment conditions.

Language: Английский

Citations

56
The role of microRNAs in the pathophysiology of human central nervous system: A focus on neurodegenerative diseases DOI
Delsuz Rezaee,

Fatemeh Saadatpour,

Nayyereh Akbari

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102090 - 102090

Published: Oct. 11, 2023

Language: Английский

Citations

46
The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing DOI Creative Commons
Yuqing Liu, Yejun Tan, Zheyu Zhang

et al.

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 23, 2024

Abstract Ageing is a crucial risk factor for Alzheimer’s disease (AD) and characterised by systemic changes in both intracellular extracellular microenvironments that affect the entire body instead of single organ. Understanding specific mechanisms underlying role ageing development can facilitate treatment ageing-related diseases, such as AD. Signs brain have been observed AD patients animal models. Alleviating pathological caused dramatically ameliorate amyloid beta- tau-induced neuropathological memory impairments, indicating plays pathophysiological process In this review, we summarize impact several age-related factors on propose preventing promising strategy improving cognitive health.

Language: Английский

Citations

36
Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway DOI Open Access

Nesrine Ebrahim,

Hajer A. Al Saihati,

Zahraa Alali

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116836 - 116836

Published: June 7, 2024

Alzheimer's disease (AD) is a devastating neurological condition characterized by cognitive decline, motor coordination impairment, and amyloid plaque accumulation.The underlying molecular mechanisms involve oxidative stress, inflammation, neuronal degeneration.This study aimed to investigate the therapeutic

Language: Английский

Citations

20
MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways DOI Creative Commons
Rachid El Fatimy, Shaomin Li, Zhicheng Chen

et al.

Acta Neuropathologica, Journal Year: 2018, Volume and Issue: 136(4), P. 537 - 555

Published: July 7, 2018

MicroRNAs (miRNA) regulate fundamental biological processes, including neuronal plasticity, stress response, and survival. Here, we describe a neuroprotective function of miR-132, the miRNA most significantly downregulated in neurons Alzheimer's disease. We demonstrate that miR-132 protects primary mouse human wild-type more vulnerable Tau-mutant against amyloid β-peptide (Aβ) glutamate excitotoxicity. It lowers levels total, phosphorylated, acetylated, cleaved forms Tau implicated tauopathies, promotes neurite elongation branching, reduces death. Similarly, attenuates PHF-Tau pathology neurodegeneration, enhances long-term potentiation P301S transgenic mice. The effects are mediated by direct regulation modifiers acetyltransferase EP300, kinase GSK3β, RNA-binding protein Rbfox1, proteases Calpain 2 Caspases 3/7. These data suggest as master regulator health indicate supplementation could be therapeutic benefit for treatment Tau-associated neurodegenerative disorders.

Language: Английский

Citations

138
MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation DOI Creative Commons
Lin Ning, Tianyu Cui, Boyang Zheng

et al.

Nucleic Acids Research, Journal Year: 2020, Volume and Issue: 49(D1), P. D160 - D164

Published: Aug. 14, 2020

Many studies have indicated that non-coding RNA (ncRNA) dysfunction is closely related to numerous diseases. Recently, accumulated ncRNA-disease associations made databases insufficient meet the demands of biomedical research. The constant updating resources has become essential. Here, we updated mammal repository (MNDR, http://www.rna-society.org/mndr/) version 3.0, containing more than one million entries, four-fold increment in data compared previous version. Experimental and predicted circRNA-disease been integrated, increasing number categories ncRNAs five, mammalian species 11. Moreover, drug annotations associations, as well ncRNA subcellular localizations interactions, were added. In addition, three (miRNA/lncRNA/circRNA) prediction tools provided, website was also optimized, making it practical user-friendly. summary, MNDR v3.0 will be a valuable resource for investigation disease mechanisms clinical treatment strategies.

Language: Английский

Citations

122