Neural Plasticity,
Год журнала:
2021,
Номер
2021, С. 1 - 10
Опубликована: Дек. 6, 2021
The
blood-brain
barrier
(BBB)
is
a
semipermeable
and
extremely
selective
system
in
the
central
nervous
of
most
vertebrates,
that
separates
blood
from
brain's
extracellular
fluid.
It
plays
vital
role
regulating
transport
necessary
materials
for
brain
function,
furthermore,
protecting
it
foreign
substances
could
damage
it.
In
this
review,
we
searched
Google
Scholar,
Pubmed,
Web
Science,
Saudi
Digital
Library
various
cells
components
support
development
function
barrier,
as
well
different
pathways
to
molecules
between
brain.
We
also
discussed
aspects
lead
BBB
dysfunction
its
neuropathological
consequences,
with
identification
some
important
biomarkers
might
be
used
biomarker
predict
disturbances.
This
comprehensive
overview
will
pave
way
future
studies
focus
on
developing
more
specific
targeting
systems
material
delivery
approach
assists
combinatorial
therapy
or
nanotherapy
destroy
modify
pathological
conditions
such
tumors
stem
cell
carcinomas.
Advanced Materials,
Год журнала:
2023,
Номер
35(32)
Опубликована: Апрель 26, 2023
Major
challenges
in
biofabrication
revolve
around
capturing
the
complex,
hierarchical
composition
of
native
tissues.
However,
individual
3D
printing
techniques
have
limited
capacity
to
produce
composite
biomaterials
with
multi-scale
resolution.
Volumetric
bioprinting
recently
emerged
as
a
paradigm-shift
biofabrication.
This
ultrafast,
light-based
technique
sculpts
cell-laden
hydrogel
bioresins
into
structures
layerless
fashion,
providing
enhanced
design
freedom
over
conventional
bioprinting.
it
yields
prints
low
mechanical
stability,
since
soft,
cell-friendly
hydrogels
are
used.
Herein,
possibility
converge
volumetric
melt
electrowriting,
which
excels
at
patterning
microfibers,
is
shown
for
fabrication
tubular
hydrogel-based
composites
behavior.
Despite
including
non-transparent
electrowritten
scaffolds
process,
high-resolution
bioprinted
successfully
achieved.
Tensile,
burst,
and
bending
properties
printed
tubes
tuned
altering
mesh
design,
resulting
multi-material
constructs
customizable,
anisotropic
geometries
that
better
mimic
intricate
biological
structures.
As
proof-of-concept,
engineered
obtained
by
building
trilayered
vessels,
features
(valves,
branches,
fenestrations)
can
be
rapidly
using
this
hybrid
approach.
multi-technology
convergence
offers
new
toolbox
manufacturing
mechanically
tunable
living
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(2), С. 386 - 386
Опубликована: Янв. 9, 2025
The
blood-brain
barrier
(BBB)
is
a
crucial
structure
that
maintains
brain
homeostasis
by
regulating
the
entry
of
molecules
and
cells
from
bloodstream
into
central
nervous
system
(CNS).
Neurodegenerative
diseases
such
as
Alzheimer's
Parkinson's
disease,
well
ischemic
stroke,
compromise
integrity
BBB.
This
leads
to
increased
permeability
infiltration
harmful
substances,
thereby
accelerating
neurodegeneration.
In
this
review,
we
explore
mechanisms
underlying
BBB
disruption,
including
oxidative
stress,
neuroinflammation,
vascular
dysfunction,
loss
tight
junction
integrity,
in
patients
with
neurodegenerative
diseases.
We
discuss
how
breakdown
contributes
neurotoxicity,
abnormal
accumulation
pathological
proteins,
all
which
exacerbate
neuronal
damage
facilitate
disease
progression.
Furthermore,
potential
therapeutic
strategies
aimed
at
preserving
or
restoring
function,
anti-inflammatory
treatments,
antioxidant
therapies,
approaches
enhance
integrity.
Given
role
neurodegeneration,
maintaining
its
represents
promising
approach
slow
prevent
progression
Frontiers in Neuroendocrinology,
Год журнала:
2022,
Номер
65, С. 100989 - 100989
Опубликована: Март 8, 2022
Prevalence
of
mental
disorders,
including
major
depressive
disorder
(MDD),
bipolar
(BD)
and
schizophrenia
(SZ)
are
increasing
at
alarming
rates
in
our
societies.
Growing
evidence
points
toward
sex
differences
these
conditions,
high
treatment
resistance
support
the
need
to
consider
novel
biological
mechanisms
outside
neuronal
function
gain
mechanistic
insights
that
could
lead
innovative
therapies.
Blood-brain
barrier
alterations
have
been
reported
MDD,
BD
SZ.
Here,
we
provide
an
overview
sex-specific
immune,
endocrine,
vascular
transcriptional-mediated
changes
affect
neurovascular
integrity
possibly
contribute
pathogenesis
disorders.
We
also
identify
pitfalls
current
literature
highlight
promising
biomarkers.
Better
understanding
how
adaptations
can
health
status
is
essential
not
only
context
SZ
but
cardiovascular
diseases
stroke
which
associated
with
higher
prevalence
conditions.
European Journal of Nuclear Medicine and Molecular Imaging,
Год журнала:
2022,
Номер
50(4), С. 1051 - 1083
Опубликована: Ноя. 28, 2022
Abstract
The
blood–brain
barrier
(BBB)
is
the
interface
between
central
nervous
system
and
systemic
circulation.
It
tightly
regulates
what
enters
removed
from
brain
parenchyma
fundamental
in
maintaining
homeostasis.
Increasingly,
BBB
recognised
as
having
a
significant
role
numerous
neurological
disorders,
ranging
acute
disorders
(traumatic
injury,
stroke,
seizures)
to
chronic
neurodegeneration
(Alzheimer’s
disease,
vascular
dementia,
small
vessel
disease).
Numerous
approaches
have
been
developed
study
vitro,
vivo,
ex
vivo.
complex
multicellular
structure
effects
of
disease
are
difficult
recreate
accurately
functional
aspects
cannot
be
easily
studied
As
such,
value
vivo
methods
intact
overstated.
This
review
discusses
function
how
these
affected
diseases.
then
depth
several
established
novel
for
imaging
with
focus
on
MRI,
nuclear
imaging,
high-resolution
intravital
fluorescence
microscopy.
Cell Proliferation,
Год журнала:
2022,
Номер
55(4)
Опубликована: Фев. 21, 2022
The
purpose
of
this
study
was
to
investigate
the
treatment
effect
and
molecular
mechanism
tetrahedral
framework
nucleic
acids
(tFNAs),
novel
self-assembled
acid
nanomaterials,
in
diffuse
BMEC
injury
after
SAH.tFNAs
were
synthesized
from
four
ssDNAs.
effects
tFNAs
on
SAH-induced
explored
by
a
cytotoxicity
model
induced
hemin,
breakdown
product
hemoglobin,
vitro
mouse
SAH
via
internal
carotid
artery
puncture
vivo.
Cell
viability
assays,
wound
healing
transwell
tube
formation
assays
performed
explore
cellular
function
like
angiogenesis.In
demonstrated
that
could
alleviate
hemin-induced
injury,
promote
angiogenesis,
inhibit
apoptosis
hemin
model.
In
vivo
using
H&E
TEM
results
jointly
indicated
attenuate
damage
caused
situ,
showing
restored
number
BMECs
endothelium
layer
more
tight
intercellular
connectivity.
Histological
examination
animals
confirmed
study,
as
exhibited
against
cerebral
microvascular
bed.Our
suggests
potential
ameliorating
SAH,
which
laid
theoretical
foundation
for
further
use
these
nanomaterials
tissue
engineering
vascularization.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Янв. 3, 2024
Abstract
Early
diagnosis
and
pharmacological
treatment
of
central
nervous
system
(CNS)
diseases
has
been
a
long-standing
challenge
for
clinical
research
due
to
the
presence
blood–brain
barrier.
Specific
proteins
RNAs
in
brain-derived
extracellular
vesicles
(EVs)
usually
reflect
corresponding
state
brain
disease,
therefore,
EVs
can
be
used
as
diagnostic
biomarkers
CNS
diseases.
In
addition,
engineered
fused
target
cells
delivery
cargo,
demonstrating
great
potential
nanocarrier
platform.
We
review
progress
markers
drug
carriers
neurological
The
main
areas
include
visual
imaging,
biomarker
loading
therapy
different
types
It
is
hoped
that
increased
knowledge
will
facilitate
their
translation
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Дек. 16, 2022
In
the
past
two
years,
world
has
faced
pandemic
caused
by
severe
acute
respiratory
syndrome
2
coronavirus
(SARS-CoV-2),
which
August
of
2022
infected
around
619
million
people
and
death
6.55
individuals
globally.
Although
SARS-CoV-2
mainly
affects
tract
level,
there
are
several
reports,
indicating
that
other
organs
such
as
heart,
kidney,
pancreas,
brain
can
also
be
damaged.
A
characteristic
observed
in
blood
serum
samples
patients
suffering
COVID-19
disease
moderate
stages,
is
a
significant
increase
proinflammatory
cytokines
interferon-α
(IFN-α),
interleukin-1β
(IL-1β),
interleukin-2
(IL-2),
interleukin-6
(IL-6)
interleukin-18
(IL-18),
well
presence
autoantibodies
against
interferon-λ
(IFN-λ),
C-C
motif
chemokine
ligand
26
(CCL26),
CXC
12
(CXCL12),
family
with
sequence
similarity
19
(chemokine
(C-C
motif)-like)
member
A4
(FAM19A4),
1
(CCL1).
Interestingly,
it
been
described
chronic
cytokinemia
related
to
alterations
blood-brain
barrier
(BBB)
permeability
induction
neurotoxicity.
Furthermore,
generation
processes
neurogenesis,
neuronal
repair,
chemotaxis
optimal
microglia
function.
These
observations
support
notion
who
survived
present
neurological
sequelae
neuropsychiatric
disorders.
The
goal
this
review
explore
relationship
between
inflammatory
humoral
immune
markers
major
damage
manifested
post-COVID-19
patients.
Molecules,
Год журнала:
2023,
Номер
28(5), С. 2336 - 2336
Опубликована: Март 3, 2023
Alzheimer's
disease
(AD)
is
to
blame
for
about
60%
of
dementia
cases
worldwide.
The
blood-brain
barrier
(BBB)
prevents
many
medications
AD
from
having
clinical
therapeutic
effects
that
can
be
used
treat
the
affected
area.
Many
researchers
have
turned
their
attention
cell
membrane
biomimetic
nanoparticles
(NPs)
solve
this
situation.
Among
them,
NPs
extend
half-life
drugs
in
body
as
"core"
wrapped
drug,
and
acts
"shell"
functionalize
NPs,
which
further
improve
delivery
efficiency
nano-drug
systems.
Researchers
are
learning
circumvent
BBB's
restriction,
prevent
harm
body's
immune
system,
period
spend
circulation,
good
biocompatibility
cytotoxicity,
increases
efficacy
drug
release.
This
review
summarized
detailed
production
process
features
core
introduced
extraction
methods
fusion
NPs.
In
addition,
targeting
peptides
modifying
target
BBB
demonstrate
broad
prospects
systems
were
summarized.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6147 - 6147
Опубликована: Март 24, 2023
Accumulating
evidence
indicates
that
chronic
exposure
to
a
low
level
of
pesticides
found
in
diet
affects
the
human
gut-microbiota-blood-brain
barrier
(BBB)
axis.
This
axis
describes
physiological
and
bidirectional
connection
between
microbiota,
intestinal
(IB),
BBB.
Preclinical
observations
reported
gut
microbial
alteration
induced
by
pesticides,
also
known
as
dysbiosis,
condition
associated
not
only
with
gastrointestinal
disorders
but
diseases
affecting
other
distal
organs,
such
However,
interplay
IB,
BBB
is
still
fully
explored.
In
this
review,
we
first
consider
similarities/differences
these
two
barriers
different
pathways
link
microbiota
better
understand
dialogue
bacteria
brain.
We
then
discuss
effects
oral
pesticide
on
gut-microbiota-BBB
raise
awareness
danger
exposure,
especially
during
perinatal
period
(pregnant
women
offspring).
