Aberrant hepatic lipid metabolism associated with gut microbiota dysbiosis triggers hepatotoxicity of novel PFOS alternatives in adult zebrafish

Environment International, Год журнала: 2022, Номер 166, С. 107351 - 107351

Опубликована: Июнь 15, 2022

Perfluorooctane sulfonate (PFOS) has been reported to induce hepatotoxicity in wildlife and humans. Novel PFOS alternatives have widely used following restrictions on PFOS, but little is known about their potential toxicity. Here, the first comprehensive investigation chronic underlying molecular mechanisms of 6:2Cl-PFESA (F-53B), sodium p-perfluorous nonenoxybenzene (OBS) was carried out adult zebrafish through a histopathological examination, biochemical measurement, multi-omics analysis. its caused changes liver histopathology function indices order F-53B > OBS, which consistent with concentration liver. In silico modeling transcriptional profiles suggested that aberrant hepatic lipid metabolism induced by initiated action peroxisome proliferator-activated receptor γ (PPARγ), triggered downstream genes transcription led an imbalance between synthesis expenditure. Gut microbiome analysis provided another novel mechanistic perspective abundance Legionella, Ralstonia, Brevundimonas, Alphaproteobacteria, Plesiomonas, Hyphomicrobium might link alterations PPAR pathway based significant correlation. This study provides insight into highlights need for concern environmental exposure risks.

Язык: Английский

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Effects of lipid levels on growth performance and glucose and lipid metabolism of adult Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diets

Aquaculture Reports, Год журнала: 2025, Номер 40, С. 102639 - 102639

Опубликована: Янв. 18, 2025

Язык: Английский

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Evaluation of growth, nutrient utilization, and metabolic function in rohu, Labeo rohita (Hamilton), fed diets incorporated with fermented Saraca asoca leaf meal

Fish Physiology and Biochemistry, Год журнала: 2025, Номер 51(1)

Опубликована: Янв. 6, 2025

Язык: Английский

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Ameliorative potential of Populus alba leaf powder against hexaflumuron exposure in Nile tilapia: immune-antioxidant, biochemical, histological, and transcriptomic analysis

Fish Physiology and Biochemistry, Год журнала: 2025, Номер 51(2)

Опубликована: Март 14, 2025

Язык: Английский

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Nutrition and Metabolism: Foundations for Animal Growth, Development, Reproduction, and Health

Advances in experimental medicine and biology, Год журнала: 2021, Номер unknown, С. 1 - 24

Опубликована: Ноя. 22, 2021

Язык: Английский

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Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet

Fish & Shellfish Immunology, Год журнала: 2022, Номер 130, С. 550 - 559

Опубликована: Сен. 27, 2022

Язык: Английский

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High Starch in Diet Leads to Disruption of Hepatic Glycogen Metabolism and Liver Fibrosis in Largemouth Bass (Micropterus salmoides), Which is Mediated by the PI3K/Akt Signaling Pathway

Frontiers in Physiology, Год журнала: 2022, Номер 13

Опубликована: Май 23, 2022

Due to its special flavour and cheapness, starch is a source of nutrition for humans most animals, some whom even prefer consume large amounts starchy foods. However, the use by carnivorous fish limited excessive intake can lead liver damage, but mechanism damage not clear. Therefore, in this study, two isonitrogenous isolipid semi-pure diets, Z diet (0% starch) G (22% starch), were formulated, respectively. The largemouth bass ( M . salmoides ) cultured fiberglass tanks randomly divided into groups fed diets 45 days. Blood collected on day 30 enzymology, histopathology, ultramicropathology, flow cytometry, transcriptomics investigate high mechanism. results showed that affect growth performance bass. caused whitening an increase hepatopancreas index (HSI), aspartate aminotransferase (AST), alanine (ALT) serum. Histopathological observations led severe vacuolisation, congestion, moderate necrotizing hepatitis liver. significant postprandial blood glucose insulin serum bass, promoting synthesis accumulation hepatic glycogen liver, leading loss hepatocyte organelles inducing fibrosis. Meanwhile, induced production oxidative stress promoted apoptosis necrosis hepatocytes. Transcriptome analysis revealed there 10,927 2,656 unique genes groups, KEGG enrichment 19 pathways significantly enriched, including those related metabolism cell survival. Network mapping based differential expressing emergence regulatory network dominated PI3K/Akt signaling pathway. This indicated signalling pathway plays very important role process, regulating injury starch. Our provide reference starch, could be potential therapeutic target

Язык: Английский

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Characteristics of the Digestive Tract of Dogs and Cats

Advances in experimental medicine and biology, Год журнала: 2024, Номер unknown, С. 15 - 38

Опубликована: Янв. 1, 2024

Язык: Английский

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Recent Advances in the Nutrition and Metabolism of Dogs and Cats

Advances in experimental medicine and biology, Год журнала: 2024, Номер unknown, С. 1 - 14

Опубликована: Янв. 1, 2024

Язык: Английский

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High Starch Induces Hematological Variations, Metabolic Changes, Oxidative Stress, Inflammatory Responses, and Histopathological Lesions in Largemouth Bass (Micropterus salmoides)

Metabolites, Год журнала: 2024, Номер 14(4), С. 236 - 236

Опубликована: Апрель 19, 2024

This study evaluated effects of high starch (20%) on hematological variations, glucose and lipid metabolism, antioxidant ability, inflammatory responses, histopathological lesions in largemouth bass. Results showed hepatic crude triacylglycerol (TAG) contents were notably increased fish fed starch. High could increase counts neutrophils, lymphocytes, monocytes, eosinophils, basophils serum TAG, TBA, BUN, LEP (

Язык: Английский

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