Placenta, Год журнала: 2023, Номер 142, С. 119 - 127
Опубликована: Сен. 6, 2023
Язык: Английский
Ageing Research Reviews, Год журнала: 2023, Номер 86, С. 101879 - 101879
Опубликована: Фев. 8, 2023
Uterine aging is an important factor that impacts fertility, reproductive health, and uterus-related diseases; however, it remains poorly explored. Functionally, these disturbances have been associated with abnormal hormonal response in the endometrium decreased endometrial receptivity. Based on emerging evidence, alterations are mediated via senescence of stem cells impaired decidualization stromal cells. Multiple molecular activities may participate uterine aging, including oxidative stress, inflammation, fibrosis, DNA damage response, cellular senescence. Over past decade, several protective strategies targeting biological processes afforded promising results, cell therapy, anti-aging drugs, herbal medicines. However, currently available evidence fragmented scattered. Here, we summarize most recent findings regarding functional structural potential mechanisms, discuss interventions against aging. Thereby, hope to provide a comprehensive understanding pathophysiological underlying mechanisms as well improve fecundity outcomes females advanced age.
Язык: Английский
Процитировано
39
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 22, 2025
Abstract An inflammatory response is related to different mediators generated by immune and endometrial cells. The links between lipopolysaccharide (LPS), cytokines, leukotrienes (LTs) in stromal cells remain unclear. This study aimed examine the influence of LPS, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-4 IL-10 on 5-lipooxygenase (5-LO), LTA4 hydrolase (LTAH) LTC4 synthase (LTCS) mRNA protein abundances, LTB4 cysteinyl (cys)-LTs release including LTC4, cultured pig cells, as well cell viability. 24-hour exposure TNF-α, up-regulated 5-LO abundances. LPS increased LTAH abundance, while IL-1β augmented TNF-α LTCS In addition, abundance was enhanced IL-4, IL-1β. Cells responded with release. stimulated Cys-LTs IL-4. All studied cytokines summary, IL-1β, are potential LTs immunomodulatory agents These functional interactions could be one mechanisms responsible for local orchestrating events inflamed healthy endometrium.
Язык: Английский
Процитировано
1
Advances in experimental medicine and biology, Год журнала: 2021, Номер unknown, С. 1 - 24
Опубликована: Ноя. 22, 2021
Язык: Английский
Процитировано
52
Molecules, Год журнала: 2022, Номер 27(18), С. 5943 - 5943
Опубликована: Сен. 13, 2022
Micro-RNAs (miRNAs) are short non-coding single-stranded RNAs that modulate the expression of various target genes after transcription. The and distribution kinds miRNAs have been characterized in human placenta during different gestational stages. identified recognized as key mediators regulation placental development maintenance pregnancy. Aberrant is associated with compromised pregnancies humans, dysregulation those contributes to occurrence related diseases pregnancy, such pre-eclampsia (PE), fetal growth restriction (FGR), diabetes mellitus (GDM), recurrent miscarriage, preterm birth (PTB) small-for-gestational-age (SGA). Thus, having a better understanding functions pregnancy thereby developing novel drugs targeting could be potentially promising method prevention treatment relevant future. Here, we summarize current knowledge pattern function diseases.
Язык: Английский
Процитировано
24
Current Opinion in Obstetrics & Gynecology, Год журнала: 2022, Номер 34(3), С. 107 - 113
Опубликована: Май 30, 2022
To succinctly review the basic mechanisms of implantation and luteal phase endometrial differentiation, etiologies impaired function receptivity, current methods that exist to evaluate treat receptivity.Human embryo requires bidirectional communication between blastocyst a receptive endometrium. Etiologies receptivity are varied. Some these include delayed maturation, structural abnormalities, inflammation, progesterone resistance. Current ultrasonography, hysteroscopy, biopsy. Treatments limited, but operative treatment endometriosis, personalized timing transfer.Although some well understood, options remain limited. Future efforts should be directed towards developing interventions targeted known mediators receptivity.
Язык: Английский
Процитировано
23
Reproduction Fertility and Development, Год журнала: 2023, Номер 36(2), С. 93 - 111
Опубликована: Окт. 9, 2023
Mammals differ regarding their placentae, but in all species placental trophoblasts interact intimately with the uterine endometrium to mediate transfer of nutrients from mother embryo/fetus through closely juxtaposed microcirculatory systems uterus and placenta. Placentation ruminants is intermediate between non-invasive type, as observed epitheliochorial placenta pigs, invasive haemochorial placentae mice humans. In ruminants, trophoblast cells invade endometrial tissue, invasion believed be limited luminal epithelium (LE). LE there are varying degrees syncytialisation among species, being more extensive sheep than cows. The hallmarks placentation include: (1) an extended period which conceptuses (embryos associated membranes) elongate must supported by secretions (histotroph) uterus; (2) a cascade involving array adhesion molecules that includes integrin-mediated attachment conceptus for implantation; (3) developing early placenta, process currently understanding; (4) development placentomes define cotyledonary cows sheep, provide haemotrophic support fetal development.
Язык: Английский
Процитировано
12
Biology of Reproduction, Год журнала: 2024, Номер 111(1), С. 174 - 185
Опубликована: Март 19, 2024
Abstract Interferon-gamma (IFNG) is a pro-inflammatory cytokine secreted by the porcine conceptus (embryo and extra-embryonic membranes) during peri-implantation period of pregnancy. IFNG modifies endometrial inflammatory immune response required for implantation survival conceptus. It not known how from trophectoderm transported across luminal epithelium (LE). In present study, immunofluorescence analyses detected immunoreactive protein in both LE on Day 15 pregnancy, while our previous research localized mRNA only to trophectoderm. Using minced explants disrupt barrier posed intact LE, treatment with recombinant induced expression genes that were when was infused into uterine lumen vivo McLendon et al. (Biology Reproduction. 2020;103(5):1018–1029). We hypothesized pregnancy extracellular vesicles (EVs) serve as intercellular signaling vehicles transport conceptus-derived stromal compartment uterus. Western blotting presence EVs isolated fluid pregnant gilts, but nonpregnant gilts. Real-time PCR demonstrated increased IFNG-stimulated EV-treated EV-mediated confirmed whole sections cultured These results suggest are involved enable paracrine communication between cells within stroma.
Язык: Английский
Процитировано
4
Advances in experimental medicine and biology, Год журнала: 2021, Номер unknown, С. 335 - 343
Опубликована: Ноя. 22, 2021
Язык: Английский
Процитировано
21
Domestic Animal Endocrinology, Год журнала: 2025, Номер 91, С. 106917 - 106917
Опубликована: Янв. 16, 2025
Язык: Английский
Процитировано
0
Theriogenology, Год журнала: 2025, Номер 237, С. 22 - 32
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0