Human Genetics, Год журнала: 2024, Номер 143(2), С. 107 - 124
Опубликована: Янв. 26, 2024
Язык: Английский
Epigenetics, Год журнала: 2019, Номер 14(12), С. 1164 - 1176
Опубликована: Июль 6, 2019
Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly related to the genesis cancer. Unlike genetic mutations, ability reprogram landscape in cancer epigenome one most promising target therapies both treatment and reversibility drug resistance. Epigenetic alterations development progression may be basis for individual variation response. Thus, this review focuses on emerging area pharmaco(epi)genomics, specifically highlighting reprogramming during tumorigenesis how markers are targeted as a therapy (epidrugs) clinical implications treatment.
Язык: Английский
Процитировано
283
Frontiers in Medicine, Год журнала: 2020, Номер 7
Опубликована: Ноя. 30, 2020
Long non-coding RNAs (lncRNAs) are major components of cellular transcripts that arising as important players in various biological pathways. They have received extensive attention recent years, regarded to be involved both developmental processes and diseases. Due their specific expression functional diversity a variety cancers, lncRNAs promising applications cancer diagnosis, prognosis therapy. Studies shown with high specificity accuracy the potential become biomarkers cancers. LncRNAs can noninvasively extracted from body fluids, tissues cells, used independent or auxiliary improve diagnosis prognosis. Currently, most well-recognized lncRNA is PCA3, which has been approved for use prostate cancer. Moreover, underlying mechanisms were explored therapeutic targets, investigated clinical trials several In this review, we presented compilation publications, patents, addressing could considered hopes providing promised implications future
Язык: Английский
Процитировано
209
Frontiers in Cell and Developmental Biology, Год журнала: 2020, Номер 8
Опубликована: Фев. 28, 2020
Pseudogenes, abundant in the human genome, are traditionally considered as non-functional "junk genes." However, recent studies have revealed that pseudogenes act key regulators at DNA, RNA or protein level diverse disorders (including cancer), among which pseudogene-derived long non-coding (lncRNA) transcripts extensively investigated and has been reported to be frequently dysregulated various types of cancer. Growing evidence demonstrates lncRNAs play important roles cancer initiation progression by serving competing endogenous RNAs (ceRNAs) through competitively binding shared microRNAs (miRNAs), thus affecting both their cognate genes unrelated genes. Herein, we retrospect those current findings about expression, functions potential ceRNA mechanisms cancer, may provide us with some crucial clues developing targets for therapy future.
Язык: Английский
Процитировано
136
Frontiers in Genetics, Год журнала: 2019, Номер 10
Опубликована: Авг. 9, 2019
In the past decade, hundreds of long noncoding RNAs (lncRNAs) have been identified as significant players in diverse types cancer; however, functions and mechanisms most lncRNAs cancer remain unclear. Several computational methods developed to detect associations between lncRNAs, yet those approaches limitations both sensitivity specificity. With goal improving prediction accuracy for lncRNA with cancer, we upgraded our previously cancer-related classifier, CRlncRC, generate CRlncRC2. CRlncRC2 is an eXtreme Gradient Boosting (XGBoost) machine learning framework, including Synthetic Minority Over-sampling Technique (SMOTE)-based over-sampling, along Laplacian Score-based feature selection. Ten-fold cross-validation showed that AUC value identification much higher than reported by CRlncRC others. Compared number features used dropped from 85 51. Finally, 439 candidates using To evaluate predictions, first consulted non-coding RNA database Lnc2Cancer v2.0 relevant literature supporting information, then conducted statistical analysis somatic mutations, distance genes, differential expression tumor tissues, various data sets. The results approach was highly reliable identifying candidates. Notably, highest ranked candidate, AC074117.1, has not previously; integrated multi-omics analyses demonstrate it target multiple miRNAs interacts adjacent protein-coding suggesting may act a competing endogenous RNA, which warrants further investigation. conclusion, effective accurate method potential contribute functional annotation guide therapy.
Язык: Английский
Процитировано
127
Toxicology and Applied Pharmacology, Год журнала: 2018, Номер 359, С. 55 - 61
Опубликована: Сен. 20, 2018
Язык: Английский
Процитировано
119
Current Pharmaceutical Design, Год журнала: 2019, Номер 25(33), С. 3563 - 3577
Опубликована: Авг. 31, 2019
Long noncoding RNAs (lncRNAs) constitute large portions of the mammalian transcriptome which appeared as a fundamental player, regulating various cellular mechanisms. LncRNAs do not encode proteins, have mRNA-like transcripts and frequently processed similar to mRNAs. Many investigations determined that lncRNAs interact with DNA, RNA molecules or proteins play significant regulatory function in several biological processes, such genomic imprinting, epigenetic regulation, cell cycle apoptosis, differentiation. can modulate gene expression on three levels: chromatin remodeling, transcription, post-transcriptional processing. The majority identified seem be transcribed by polymerase II. Recent evidence has illustrated dysregulation lead many human diseases, particular, cancer. aberrant malignancies contributes proliferation differentiation process. Consequently, useful diagnosis, treatment, prognosis, been characterized potential cancer markers well. In this review, we highlighted role molecular mechanisms their correlation some cancers.
Язык: Английский
Процитировано
112
Pathology - Research and Practice, Год журнала: 2018, Номер 214(6), С. 801 - 805
Опубликована: Апрель 25, 2018
Язык: Английский
Процитировано
106
Molecular Cell, Год журнала: 2021, Номер 81(21), С. 4493 - 4508.e9
Опубликована: Ноя. 1, 2021
Язык: Английский
Процитировано
80
Cancers, Год журнала: 2019, Номер 11(10), С. 1524 - 1524
Опубликована: Окт. 10, 2019
During the last decade, high-throughput sequencing efforts in fields of transcriptomics and epigenomics have shed light on noncoding part transcriptome its potential role human disease. Regulatory RNAs are broadly divided into short long transcripts. The latter, also known as lncRNAs, defined transcripts longer than 200 nucleotides with low or no protein-coding potential. LncRNAs form a diverse group that regulate vital cellular functions through interactions proteins, chromatin, even RNA itself. Notably, an important regulatory aspect these species is their association epigenetic machinery recruitment apparatus to specific loci, resulting DNA methylation and/or post-translational modifications histones. Such play pivotal maintaining active inactive transcriptional state chromatin crucial regulators normal development tissue-specific gene expression. Evidently, aberrant expression lncRNAs interact modifiers can cause severe disruption thus closely associated altered function, dysregulation, malignant transformation. Here, we survey latest breakthroughs concerning interacting various forms cancer.
Язык: Английский
Процитировано
76
Cell Proliferation, Год журнала: 2019, Номер 52(4)
Опубликована: Апрель 30, 2019
Abstract Objectives This research aims to verify that the long non‐coding RNA differentiation antagonizing nonprotein coding (LncRNA DANCR) could modulate proliferation and metastasis of hepatocellular carcinoma (HCC), it thus may work as a novel biomarker render new orientation for early diagnosis clinical therapy HCC. Materials methods Firstly, qRT‐PCR was used detect expression genes including LncRNA DANCR miR‐27a‐3p. Next, MTT assay, Ethynyldeoxyuridine (EdU) analysis clone formation assay were investigating cell growth proliferation. Meanwhile, transwell wound healing applied evaluate capacity motility, respectively. In addition, bioinformatic dual‐luciferase reporter analyse molecular interaction. we conducted immunofluorescence Western blot mechanic investigation. Last but not least, xenograft tumours in nude mice built by subcutaneously injecting Hep3B cells stably transfected with sh‐NC sh‐DANCR SMMC‐7721 investigate metastasis. Results The results revealed high accelerated HCC knockdown had opposite effect. group grow slower have smaller volumes compared negative control group. antineoplastic effect miR‐27a‐3p on motility confirmed. clarified acted ceRNA decoy via mediating ROCK1/LIMK1/COFILIN1 pathway. end, validated DANCR/miR‐27a‐3p axis regulates EMT progression blot. Conclusions word, promotes development induces decoying regulate
Язык: Английский
Процитировано
72