<p>lncRNA LINC00460 promoted colorectal cancer cells metastasis via miR-939-5p sponging</p> DOI Creative Commons
Yueyan Zhang, Xingchi Liu, Qiang Li

et al.

Cancer Management and Research, Journal Year: 2019, Volume and Issue: Volume 11, P. 1779 - 1789

Published: Feb. 1, 2019

lncRNAs are widely involved in multiple malignancies including colorectal cancer (CRC). The expression and function of long intergenic non-protein coding RNA 460 (LINC00460) CRC remains obscure.In the present study, quantitative real-time PCR assays were applied to detect changes LINC00460 microRNA-939-5p (miR-939-5p) tissue specimens cell lines. Western blot used measure LIMK2. Bioinformatics analysis, luciferase assays, pull-down determine targeting binding effect between miR-939-5p as well LIMK2 miR-939-5p. Transwell evaluate metastatic ability line HT29 LOVO cells.We found that was upregulated closely correlated clinicopathological features poor prognosis patients with CRC. Functionally, we elucidated promoted metastasis lines LOVO. Further, showed a downstream effector LINC00460-induced promotion cells Through online bioinformatics demonstrated share similar microRNA response elements for Then, verified be targets via assay an assay. Also, suppress by Lastly, revealed LIMK2-mediated sponging LOVO.The findings this study works oncogene regulation miR-939-3p/LIMK2 axial. might provide new target treating

Language: Английский

Epidrugs: targeting epigenetic marks in cancer treatment DOI Open Access
Cristiana Libardi Miranda Furtado, Maria Cláudia dos Santos Luciano, Renan da Silva Santos

et al.

Epigenetics, Journal Year: 2019, Volume and Issue: 14(12), P. 1164 - 1176

Published: July 6, 2019

Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly related to the genesis cancer. Unlike genetic mutations, ability reprogram landscape in cancer epigenome one most promising target therapies both treatment and reversibility drug resistance. Epigenetic alterations development progression may be basis for individual variation response. Thus, this review focuses on emerging area pharmaco(epi)genomics, specifically highlighting reprogramming during tumorigenesis how markers are targeted as a therapy (epidrugs) clinical implications treatment.

Language: Английский

Citations

283
Long Non-coding RNAs in Cancer: Implications for Diagnosis, Prognosis, and Therapy DOI Creative Commons

Yuchen Qian,

Lei Shi, Zhong Luo

et al.

Frontiers in Medicine, Journal Year: 2020, Volume and Issue: 7

Published: Nov. 30, 2020

Long non-coding RNAs (lncRNAs) are major components of cellular transcripts that arising as important players in various biological pathways. They have received extensive attention recent years, regarded to be involved both developmental processes and diseases. Due their specific expression functional diversity a variety cancers, lncRNAs promising applications cancer diagnosis, prognosis therapy. Studies shown with high specificity accuracy the potential become biomarkers cancers. LncRNAs can noninvasively extracted from body fluids, tissues cells, used independent or auxiliary improve diagnosis prognosis. Currently, most well-recognized lncRNA is PCA3, which has been approved for use prostate cancer. Moreover, underlying mechanisms were explored therapeutic targets, investigated clinical trials several In this review, we presented compilation publications, patents, addressing could considered hopes providing promised implications future

Language: Английский

Citations

203
Pseudogene-Derived lncRNAs and Their miRNA Sponging Mechanism in Human Cancer DOI Creative Commons
Weiyang Lou,

Bisha Ding,

Peifen Fu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: Feb. 28, 2020

Pseudogenes, abundant in the human genome, are traditionally considered as non-functional "junk genes." However, recent studies have revealed that pseudogenes act key regulators at DNA, RNA or protein level diverse disorders (including cancer), among which pseudogene-derived long non-coding (lncRNA) transcripts extensively investigated and has been reported to be frequently dysregulated various types of cancer. Growing evidence demonstrates lncRNAs play important roles cancer initiation progression by serving competing endogenous RNAs (ceRNAs) through competitively binding shared microRNAs (miRNAs), thus affecting both their cognate genes unrelated genes. Herein, we retrospect those current findings about expression, functions potential ceRNA mechanisms cancer, may provide us with some crucial clues developing targets for therapy future.

Language: Английский

Citations

136
Identification of Cancer-Related Long Non-Coding RNAs Using XGBoost With High Accuracy DOI Creative Commons
Xuan Zhang, Tianjun Li, Jun Wang

et al.

Frontiers in Genetics, Journal Year: 2019, Volume and Issue: 10

Published: Aug. 9, 2019

In the past decade, hundreds of long noncoding RNAs (lncRNAs) have been identified as significant players in diverse types cancer; however, functions and mechanisms most lncRNAs cancer remain unclear. Several computational methods developed to detect associations between lncRNAs, yet those approaches limitations both sensitivity specificity. With goal improving prediction accuracy for lncRNA with cancer, we upgraded our previously cancer-related classifier, CRlncRC, generate CRlncRC2. CRlncRC2 is an eXtreme Gradient Boosting (XGBoost) machine learning framework, including Synthetic Minority Over-sampling Technique (SMOTE)-based over-sampling, along Laplacian Score-based feature selection. Ten-fold cross-validation showed that AUC value identification much higher than reported by CRlncRC others. Compared number features used dropped from 85 51. Finally, 439 candidates using To evaluate predictions, first consulted non-coding RNA database Lnc2Cancer v2.0 relevant literature supporting information, then conducted statistical analysis somatic mutations, distance genes, differential expression tumor tissues, various data sets. The results approach was highly reliable identifying candidates. Notably, highest ranked candidate, AC074117.1, has not previously; integrated multi-omics analyses demonstrate it target multiple miRNAs interacts adjacent protein-coding suggesting may act a competing endogenous RNA, which warrants further investigation. conclusion, effective accurate method potential contribute functional annotation guide therapy.

Language: Английский

Citations

127
Knockdown of lncRNA H19 restores chemo-sensitivity in paclitaxel-resistant triple-negative breast cancer through triggering apoptosis and regulating Akt signaling pathway DOI
Jiguang Han,

Baojuan Han,

Xueya Wu

et al.

Toxicology and Applied Pharmacology, Journal Year: 2018, Volume and Issue: 359, P. 55 - 61

Published: Sept. 20, 2018

Language: Английский

Citations

119
Long Non-Coding RNAs As Epigenetic Regulators in Cancer DOI
Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour

et al.

Current Pharmaceutical Design, Journal Year: 2019, Volume and Issue: 25(33), P. 3563 - 3577

Published: Aug. 31, 2019

Long noncoding RNAs (lncRNAs) constitute large portions of the mammalian transcriptome which appeared as a fundamental player, regulating various cellular mechanisms. LncRNAs do not encode proteins, have mRNA-like transcripts and frequently processed similar to mRNAs. Many investigations determined that lncRNAs interact with DNA, RNA molecules or proteins play significant regulatory function in several biological processes, such genomic imprinting, epigenetic regulation, cell cycle apoptosis, differentiation. can modulate gene expression on three levels: chromatin remodeling, transcription, post-transcriptional processing. The majority identified seem be transcribed by polymerase II. Recent evidence has illustrated dysregulation lead many human diseases, particular, cancer. aberrant malignancies contributes proliferation differentiation process. Consequently, useful diagnosis, treatment, prognosis, been characterized potential cancer markers well. In this review, we highlighted role molecular mechanisms their correlation some cancers.

Language: Английский

Citations

112
LncRNA-DANCR: A valuable cancer related long non-coding RNA for human cancers DOI

Khaing Zar Thin,

Xuefang Liu, Xiaobo Feng

et al.

Pathology - Research and Practice, Journal Year: 2018, Volume and Issue: 214(6), P. 801 - 805

Published: April 25, 2018

Language: Английский

Citations

106
The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation DOI Creative Commons

Lin-Yu Sun,

Wentao Wang, Cai Han

et al.

Molecular Cell, Journal Year: 2021, Volume and Issue: 81(21), P. 4493 - 4508.e9

Published: Nov. 1, 2021

Language: Английский

Citations

80
LncRNAs as Chromatin Regulators in Cancer: From Molecular Function to Clinical Potential DOI Open Access

Rodiola Begolli,

Nikolaos Sideris, Antonis Giakountis

et al.

Cancers, Journal Year: 2019, Volume and Issue: 11(10), P. 1524 - 1524

Published: Oct. 10, 2019

During the last decade, high-throughput sequencing efforts in fields of transcriptomics and epigenomics have shed light on noncoding part transcriptome its potential role human disease. Regulatory RNAs are broadly divided into short long transcripts. The latter, also known as lncRNAs, defined transcripts longer than 200 nucleotides with low or no protein-coding potential. LncRNAs form a diverse group that regulate vital cellular functions through interactions proteins, chromatin, even RNA itself. Notably, an important regulatory aspect these species is their association epigenetic machinery recruitment apparatus to specific loci, resulting DNA methylation and/or post-translational modifications histones. Such play pivotal maintaining active inactive transcriptional state chromatin crucial regulators normal development tissue-specific gene expression. Evidently, aberrant expression lncRNAs interact modifiers can cause severe disruption thus closely associated altered function, dysregulation, malignant transformation. Here, we survey latest breakthroughs concerning interacting various forms cancer.

Language: Английский

Citations

76
Long non-coding RNAs in cancer: multifaceted roles and potential targets for immunotherapy DOI
Lokesh Kadian, Deepika Verma, Neelam Lohani

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 479(12), P. 3229 - 3254

Published: Feb. 28, 2024

Language: Английский

Citations

8