Contribution of tumor microenvironment (TME) to tumor apoptosis, angiogenesis, metastasis, and drug resistance
Medical Oncology,
Год журнала:
2025,
Номер
42(4)
Опубликована: Март 14, 2025
Язык: Английский
Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies
Cells,
Год журнала:
2024,
Номер
13(11), С. 958 - 958
Опубликована: Июнь 1, 2024
Autophagy
is
a
globally
conserved
cellular
activity
that
plays
critical
role
in
maintaining
homeostasis
through
the
breakdown
and
recycling
of
constituents.
In
recent
years,
there
has
been
much
emphasis
given
to
its
complex
cancer
stem
cells
(CSCs)
cell
treatment.
This
study
examines
molecular
processes
support
autophagy
how
it
regulated
context
CSCs
Although
dual
management
CSCs,
affecting
their
removal
as
well
maintenance,
intricate
interaction
between
several
signaling
channels
control
survival
death
part
mechanism
not
elucidated.
Given
have
development,
progression,
resistance
treatment
tumors,
imperative
comprehend
biological
activities.
are
important
for
biology
because
they
also
show
tissue
regeneration
model
helps
with
organoid
regeneration.
other
words,
manipulation
viable
therapeutic
approach
therapy.
Both
synthetic
natural
substances
target
pathways
demonstrated
promise
improving
cell-based
therapies
eliminating
CSCs.
Nevertheless,
difficulties
associated
limitations
CSC
regulation,
including
mechanisms
off-target
effects.
Thus,
regulation
offers
versatile
strategy
focusing
on
enhancing
results
Therefore,
understanding
interactions
would
be
essential
creating
treatments
work
both
regenerative
medicine
Язык: Английский
Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Март 18, 2025
In
the
domain
of
addressing
cancer
resistance,
challenges
such
as
limited
effectiveness
and
treatment
resistance
remain
persistent.
Hypoxia
is
a
key
feature
solid
tumors
strongly
associated
with
poor
prognosis
in
patients.
Another
significant
portion
development
acquired
drug
attributed
to
tumor
stemness.
Cancer
stem
cells
(CSCs),
small
cell
subset
self-renewal
proliferative
abilities,
are
crucial
for
initiation,
metastasis,
intra-tumoral
heterogeneity.
Studies
have
shown
association
between
hypoxia
CSCs
context
resistance.
Recent
studies
reveal
strong
link
stemness,
which
together
promote
survival
progression
during
treatment.
This
review
elucidates
interplay
CSCs,
well
their
correlation
therapeutic
drugs.
Targeting
pivotal
genes
stemness
holds
promise
novel
therapeutics
combat
Язык: Английский