Contribution of tumor microenvironment (TME) to tumor apoptosis, angiogenesis, metastasis, and drug resistance

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 14, 2025

Language: Английский

Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 18, 2025

In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. Hypoxia is a key feature solid tumors strongly associated with poor prognosis in patients. Another significant portion development acquired drug attributed to tumor stemness. Cancer stem cells (CSCs), small cell subset self-renewal proliferative abilities, are crucial for initiation, metastasis, intra-tumoral heterogeneity. Studies have shown association between hypoxia CSCs context resistance. Recent studies reveal strong link stemness, which together promote survival progression during treatment. This review elucidates interplay CSCs, well their correlation therapeutic drugs. Targeting pivotal genes stemness holds promise novel therapeutics combat

Language: Английский

Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 958 - 958

Published: June 1, 2024

Autophagy is a globally conserved cellular activity that plays critical role in maintaining homeostasis through the breakdown and recycling of constituents. In recent years, there has been much emphasis given to its complex cancer stem cells (CSCs) cell treatment. This study examines molecular processes support autophagy how it regulated context CSCs Although dual management CSCs, affecting their removal as well maintenance, intricate interaction between several signaling channels control survival death part mechanism not elucidated. Given have development, progression, resistance treatment tumors, imperative comprehend biological activities. are important for biology because they also show tissue regeneration model helps with organoid regeneration. other words, manipulation viable therapeutic approach therapy. Both synthetic natural substances target pathways demonstrated promise improving cell-based therapies eliminating CSCs. Nevertheless, difficulties associated limitations CSC regulation, including mechanisms off-target effects. Thus, regulation offers versatile strategy focusing on enhancing results Therefore, understanding interactions would be essential creating treatments work both regenerative medicine

Language: Английский