Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(18), С. 10043 - 10043

Опубликована: Сен. 17, 2021

Inflammation is among the core causatives of male infertility. Despite infertility being a serious global issue, "bits and pieces" its complex etiopathology still remain missing. During inflammation, levels proinflammatory mediators in reproductive tract are greater than usual. According to epidemiological research, numerous cases infertility, patients suffer from acute or chronic inflammation genitourinary which typically occurs without symptoms. Inflammatory responses genital system inextricably linked oxidative stress (OS). OS detrimental fertility parameters as it causes damage cells intracellular components. Multifarious causative factors pave way for impairing functions via common mechanisms both interlinked pathophysiological processes, occurrence any one them induces other. Both processes may be simultaneously found pathogenesis Thus, present article aims explain role detail, well show mechanistic pathways that link induction, oxidant-sensitive cellular cascades leading

Язык: Английский

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Mitochondria: Their relevance during oocyte ageing

Ageing Research Reviews, Год журнала: 2021, Номер 70, С. 101378 - 101378

Опубликована: Июнь 4, 2021

The oocyte is recognised as the largest cell in mammalian species and other multicellular organisms. Mitochondria represent a high proportion of cytoplasm oocytes mitochondrial architecture different than somatic cells, characterised by rounder appearance fragmented network. Although number mitochondria per higher any cell, their activity decrease with advancing age. integrate numerous processes essential for cellular function, such metabolic related to energy production, biosynthesis, waste removal, well Ca2+ signalling reactive oxygen (ROS) homeostasis. Further, are responsible adaptation types stressors oxidative stress or DNA damage. When these outstrip adaptive capacity restore homeostasis, it leads dysfunction. Decades studies indicate that function multifaceted, which reflected oocyte, where support during maturation, fertilization, early embryonic development. Dysregulation has been consistently reported ageing age-related diseases. In this review, we describe functions bioenergetic powerhouses signal transducers oocytes, how dysfunction contributes reproductive ageing, whether could be targeted promote rejuvenation.

Язык: Английский

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The Impact of Oxidative Stress in Male Infertility

Frontiers in Molecular Biosciences, Год журнала: 2022, Номер 8

Опубликована: Янв. 5, 2022

At present infertility is affecting about 15% of couples and male factor responsible for almost 50% cases. Oxidative stress, due to enhanced Reactive Oxygen Species (ROS) production and/or decreased antioxidants, has been repeatedly suggested as a new emerging causative this condition. However, the central roles exerted by ROS in sperm physiology cannot be neglected. On these bases, review focused on illustrating both role their main sources production. stress assessment, clinical use redox biomarkers treatment oxidative stress-related are also discussed.

Язык: Английский

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Mitochondrial Reactive Oxygen Species (ROS) Production Alters Sperm Quality

Antioxidants, Год журнала: 2021, Номер 10(1), С. 92 - 92

Опубликована: Янв. 11, 2021

Besides ATP production, mitochondria are key organelles in several cellular functions, such as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the generation of reactive oxygen species (ROS). Despite loss majority cytoplasm occurring during spermiogenesis, mammalian sperm preserves a number that rearrange tubular structure at level flagellum midpiece. Although destroyed inside zygote, integrity functionality these seem to be critical for fertilization embryo development. The aim this review was discuss impact mitochondria-produced ROS multiple levels sperm: genome, proteome, lipidome, epigenome. How diet, aging environmental pollution may affect quality offspring health—by exacerbating oxidative stress—will also described.

Язык: Английский

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Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Perimenopause is an important stage of female senescence. Epidemiological investigation has shown that the incidence cardiovascular disease in premenopausal women lower than men, and postmenopausal significantly higher men. This phenomenon reveals estrogen a definite protective effect on system. In system, oxidative stress considered pathogenesis atherosclerosis, myocardial dysfunction, cardiac hypertrophy, heart failure, ischemia. From perspective stress, plays regulatory role system through receptor, providing strategies for treatment menopausal with diseases.

Язык: Английский

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Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms

Antioxidants, Год журнала: 2022, Номер 11(2), С. 306 - 306

Опубликована: Фев. 2, 2022

Reactive oxygen species (ROS) play a critical role in defining the functional competence of human spermatozoa. When generated moderate amounts, ROS promote sperm capacitation by facilitating cholesterol efflux from plasma membrane, enhancing cAMP generation, inducing cytoplasmic alkalinization, increasing intracellular calcium levels, and stimulating protein phosphorylation events that drive attainment capacitated state. However, when generation is excessive and/or antioxidant defences reproductive system are compromised, state oxidative stress may be induced disrupts fertilizing capacity spermatozoa structural integrity their DNA. This article focusses on sources within this examines circumstances under which adequacy protection might become limiting factor. Seminal leukocyte contamination can contribute to ejaculate while, germ line, dysregulation electron transport mitochondria, elevated NADPH oxidase activity, or stimulation amino acid action all potential contributors stress. A knowledge mechanisms responsible for creating such essential order develop better strategies avoid unintentional creation its reductive counterpart.

Язык: Английский

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Oxidative Stress and Male Infertility: The Protective Role of Antioxidants

Medicina, Год журнала: 2023, Номер 59(10), С. 1769 - 1769

Опубликована: Окт. 4, 2023

Oxidative stress is a significant factor in male infertility, compromising sperm function and overall reproductive health. As infertility garners increasing attention, effective therapeutic interventions become paramount. This review investigates the role of antioxidants addressing infertility. A detailed examination was conducted on such as vitamin C, E, B12, D, coenzyme Q10, zinc, folic acid, selenium, l-carnitine, l-arginine, inositols, alpha-lipoic acid. analysis examines methodologies, outcomes, constraints current clinical studies. Antioxidants show notable potential counteracting negative effects oxidative sperm. Based evidence, these antioxidants, individually or synergistically, can enhance health outcomes. However, certain limitations studies call for careful interpretation. are integral tackling attributed to stress. The findings underscore their value, yet there’s pressing need deeper, comprehensive research. Future should focus refining dosage guidelines, identifying side effects, discerning most efficacious antioxidant combinations solutions.

Язык: Английский

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Kaempferol, a potential neuroprotective agent in neurodegenerative diseases: From chemistry to medicine

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115215 - 115215

Опубликована: Июль 24, 2023

Neurodegenerative diseases (NDDs) encompass a range of conditions that involve progressive deterioration and dysfunction the nervous system. Some common NDDs include Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), amyotrophic lateral sclerosis (ALS). Although significant progress has been made in understanding pathological mechanisms recent years, development targeted effective drugs for their treatment remains challenging. Kaempferol is flavonoid whose derivatives kaempferol-O-rhamnoside, 3-O-β-rutinoside/6-hydroxykaempferol 3,6-di-O-β-d-glucoside, kaempferide. Emerging studies have suggested kaempferol its possess neuroprotective properties may potential therapeutic benefits NDDs. Here, we aimed to provide theoretical basis use clinical We systematically reviewed literature PubMed, Web Science, Science Direct databases until June 2022 using search terms "kaempferol," "kaempferol derivatives," "NDDs," "pharmacokinetics," "biosynthesis" according reporting items systematic review (PRISMA) standard. Based on combined results vivo vitro studies, summarize basic targets management AD, PD, HD, ALS. exert role mainly by preventing deposition amyloid fibrils (such as Aβ, tau, α-synuclein), inhibiting microglia activation, reducing release inflammatory factors, restoring mitochondrial membrane prevent oxidative stress, protecting blood-brain barrier, specific enzyme activities cholinesterase). are promising natural agents. By determining pharmacological mechanism, be new candidate

Язык: Английский

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Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(2), С. 198 - 198

Опубликована: Фев. 11, 2024

Semen quality represents a compelling factor for fertility, and delineating the normal values has proven difficult. In last four decades, several authors have reported noticeable decline in sperm parameters. Also, studies investigating ‘time to pregnancy’ shown that fecundity begins be reduced when numbers decrease below 30 million, even though according 6th edition of WHO manual, value is currently 16 million/mL or 39 million per ejaculate. There exists sufficient data suggest counts over time, clear reason this adverse trend not well established, but some associations been hypothesised, such as maternal smoking during pregnancy. Additional potential factors yet fully illustrated involve poor diet, increased obesity, exposure environmental toxins. Moreover, change conditions more common endocrine-disrupting chemicals (EDCs), pesticides herbicides, bisphenol A, phthalates, polychlorinated biphenyls, heavy metals, starting from prenatal life continuing into adulthood, may exhibit probable features explaining reduction Therefore, main goal narrative review furnish an overview possible effects EDCs on testicular function spermatogenesis and, also, summarise evidence regarding examine its consequences.

Язык: Английский

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A review of the neurobehavioural, physiological, and reproductive toxicity of microplastics in fishes

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 282, С. 116712 - 116712

Опубликована: Июль 15, 2024

Microplastics (MPs) have emerged as widespread environmental pollutants, causing significant threats to aquatic ecosystems and organisms.This review examines the toxic effects of MPs on fishes, with a focus neurobehavioural, physiological, reproductive impacts, well underlying mechanisms toxicity.Evidence indicates that induce range neurobehavioural abnormalities in affecting social interactions cognitive functions.Altered neurotransmitter levels are identified key mechanism driving behavioural alterations following MP exposure.Physiological fishes exposed also reported, including neurotoxicity, immunotoxicity, oxidative stress.These physiological disruptions can compromise individual health organisms.Furthermore, linked exposure discussed, particular emphasis endocrine signaling pathways.These impair success fish species, impacting population numbers.Here we explore critical role mediating after MPs, focusing primarily hypothalamic-pituitary-gonadal axis.Our highlights urgent need for interdisciplinary research efforts aimed at elucidating full extent toxicity its implications ecosystems.Lastly, identify knowledge gaps future research, investigations into transgenerational if any, quantifying synergetic/antagonistic other pollutants.This expanded regarding potential risks wildlife is expected aid policymakers developing mitigation strategies protect species.

Язык: Английский

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