The
mechanisms
contributing
to
age-related
deterioration
of
the
female
reproductive
system
are
complex,
however
aberrant
protein
homeostasis
is
a
major
contributor.
We
elucidated
exceptionally
stable
proteins,
structures,
and
macromolecules
that
persist
in
mammalian
ovaries
gametes
across
lifespan.
Ovaries
exhibit
localized
structural
cell-type-specific
enrichment
both
follicular
extrafollicular
environments.
Moreover,
oocytes
harbor
panel
long-lived
including
cytoskeletal,
mitochondrial,
oocyte-derived
proteins.
exceptional
persistence
these
molecules
suggest
critical
role
lifelong
maintenance
age-dependent
tissues.
Antioxidants,
Год журнала:
2023,
Номер
12(4), С. 860 - 860
Опубликована: Апрель 2, 2023
It
is
more
effective
to
maintain
good
health
than
regain
it
after
losing
it.
This
work
focuses
on
the
biochemical
defense
mechanisms
against
free
radicals
and
their
role
in
building
maintaining
antioxidant
shields,
aiming
show
how
balance,
as
much
possible,
situations
which
we
are
exposed
radicals.
To
achieve
this
aim,
foods,
fruits,
marine
algae
with
a
high
content
should
constitute
basis
of
nutritional
elements,
since
natural
products
known
have
significantly
greater
assimilation
efficiency.
review
also
gives
perspective
use
antioxidants
can
extend
life
food
products,
by
protecting
them
from
damage
caused
oxidation
well
additives.
The Journal of Clinical Endocrinology & Metabolism,
Год журнала:
2023,
Номер
108(8), С. 1835 - 1874
Опубликована: Июнь 16, 2023
Multiple
changes
occur
across
various
endocrine
systems
as
an
individual
ages.
The
understanding
of
the
factors
that
cause
age-related
and
how
they
should
be
managed
clinically
is
evolving.
This
statement
reviews
current
state
research
in
growth
hormone,
adrenal,
ovarian,
testicular,
thyroid
axes,
well
osteoporosis,
vitamin
D
deficiency,
type
2
diabetes,
water
metabolism,
with
a
specific
focus
on
older
individuals.
Each
section
describes
natural
history
observational
data
individuals,
available
therapies,
clinical
trial
efficacy
safety
key
points,
scientific
gaps.
goal
this
to
inform
future
refines
prevention
treatment
strategies
age-associated
conditions,
improving
health
Antioxidants,
Год журнала:
2023,
Номер
12(3), С. 695 - 695
Опубликована: Март 11, 2023
Aging
has
a
major
detrimental
effect
on
the
optimal
function
of
ovary
with
changes
in
this
organ
preceding
age-related
deterioration
other
tissues,
middle-aged
shutdown
leading
to
infertility.
Reduced
fertility
and
consequent
inability
conceive
by
women
present-day
societies
who
choose
have
children
later
life
leads
increased
frustration.
Melatonin
is
known
anti-aging
properties
related
its
antioxidant
anti-inflammatory
actions.
Its
higher
follicular
fluid
levels
relative
blood
concentrations
likely
synthesis
oocyte,
granulosa,
luteal
cells
suggest
that
it
optimally
positioned
interfere
age-associated
ovary.
Additionally,
end
female
reproductive
span
coincides
significant
reduction
endogenous
melatonin
levels.
Thus,
aims
are
review
literature
indicating
production
mitochondria
oocytes,
granulosa
cells,
identify
multiple
processes
underlying
ovary,
especially
late
cessation
span,
summarize
physiological
molecular
actions
maintenance
normal
ovaries
aging
ovaries,
integrate
acquired
information
into
an
explanation
for
considering
treatment
Use
supplemental
may
help
preserve
alleviate
frustration
delaying
childbearing
age,
reduce
necessity
vitro
fertilization–embryo
transfer
(IVF-ET)
procedures,
solve
progressively
increasing
problem
non-aging-related
infertility
throughout
their
span.
While
additional
research
needed
fully
understand
effects
supplementation
potentially
enhancing
fertility,
studies
published
date
be
promising
option
those
struggling
Recent
advances
highlight
the
pivotal
role
of
nicotinamide
adenine
dinucleotide
(NAD+
)
in
ovarian
aging.
However,
roles
de
novo
NAD+
biosynthesis
on
aging
are
still
unknown.
Here,
we
found
that
genetic
ablation
Ido1
(indoleamine-2,3-dioxygenase
1)
or
Qprt
(Quinolinate
phosphoribosyl
transferase),
two
critical
genes
biosynthesis,
resulted
decreased
levels
middle-aged
mice,
leading
to
subfertility,
irregular
estrous
cycles,
reduced
reserve,
and
accelerated
Moreover,
observed
impaired
oocyte
quality,
characterized
by
increased
reactive
oxygen
species
spindle
anomalies,
which
ultimately
led
fertilization
ability
early
embryonic
development.
A
transcriptomic
analysis
ovaries
both
mutant
wild-type
mice
revealed
alterations
gene
expression
related
mitochondrial
metabolism.
Our
findings
were
further
supported
observation
distribution
membrane
potential
oocytes
knockout
mice.
Supplementation
with
riboside
(NR),
an
booster,
reserve
improved
quality.
study
highlights
importance
pathway
female
fertility.
Journal of Ovarian Research,
Год журнала:
2024,
Номер
17(1)
Опубликована: Май 31, 2024
Abstract
In
women
who
are
getting
older,
the
quantity
and
quality
of
their
follicles
or
oocytes
decline.
This
is
characterized
by
decreased
ovarian
reserve
function
(DOR),
fewer
remaining
oocytes,
lower
oocytes.
As
more
choose
to
delay
childbirth,
decline
in
fertility
associated
with
age
has
become
a
significant
concern
for
modern
women.
The
oocyte
key
indicator
aging.
Many
studies
suggest
that
age-related
changes
energy
metabolism
may
impact
quality.
Changes
affect
adenosine
5'-triphosphate
(ATP)
production,
but
how
related
products
proteins
influence
remains
largely
unknown.
review
focuses
on
aging
its
potential
quality,
as
well
therapeutic
strategies
partially
metabolism.
research
aims
enhance
our
understanding
metabolism,
identification
biomarkers
treatment
methods.
ACS Nano,
Год журнала:
2024,
Номер
18(21), С. 13618 - 13634
Опубликована: Май 13, 2024
Postovulatory
aging
oocytes
usually
feature
diminished
potential
for
fertilization
and
poor
embryonic
development
due
to
enhanced
oxidative
damage
the
subcellular
organelles
macromolecules,
which
stands
as
a
formidable
obstacle
in
assisted
reproductive
technologies
(ART).
Here,
we
developed
lipoic
acid
(LA)
polyethylene
glycol
(PEG)-modified
CeO2
nanoparticles
(LA-PEG-CeNPs)
with
biocompatibility,
enzyme-like
autocatalytic
activity,
free
radical
scavenging
capacity.
We
further
investigated
LA-PEG-CeNPs
effect
mouse
postovulatory
during
vitro
aging.
The
results
showed
that
dramatically
reduced
accumulation
of
ROS
oocytes,
improving
mitochondrial
dysfunction;
they
also
down-regulated
pro-apoptotic
activity
by
rectifying
cellular
caspase-3,
cleaved
Bcl-2
levels.
Consistently,
this
nanoenzyme
prominently
alleviated
proportion
abnormalities
spindle
structure,
chromosome
alignment,
microtubule
stability,
filamentous
actin
(F-actin)
distribution
furthermore
decreased
oocyte
fragmentation,
improved
its
ability
blastocyst.
Taken
together,
our
finding
suggests
can
alleviate
stress
on
quality
aging,
implying
their
value
clinical
practice
reproduction.
Cells,
Год журнала:
2024,
Номер
13(5), С. 415 - 415
Опубликована: Фев. 27, 2024
With
the
increase
in
age
of
laying
chickens,
aging
follicles
is
accelerated,
and
reproductive
ability
decreased.
Increased
oxidative
stress
mitochondrial
malfunction
are
indispensable
causes
ovarian
aging.
In
this
study,
physiological
condition
prehierarchical
small
white
(SWFs)
was
compared
between
D280
high-producing
chickens
D580
effect
a
plant-derived
flavonoid
nobiletin
(Nob),
natural
antioxidant,
on
senescence
SWFs
granulosa
cells
(SWF-GCs)
investigated.
The
results
showed
that
Nob
treatment
activated
cell
autophagy
by
activating
AMP-activated
protein
kinase
(AMPK)
Sirtuin-1
(SIRT1)
pathways
D-galactose
(D-gal)-generated
senescent
SWF-GCs,
restoring
expression
proliferation-related
mRNAs
proteins.
addition,
inflammation-related
NF-κB
significantly
enhanced
GCs
were
induced
D-gal.
supplementation
increased
antioxidant
capacity
decreased
several
genes
associated
with
apoptosis.
Furthermore,
promoted
activation
PINK1
Parkin
for
mitophagy
alleviated
edema.
Either
AMPK
inhibitor
dorsomorphin
(Compound
C)
or
SIRT1
selisistat
(EX-527)
attenuated
mitophagy.
protective
aging,
GC
proliferation,
elimination
beneficial
impact
energy
regulation
naturally
ovaries
diminished
inhibition
Nob-mediated
autophagy.
These
data
suggest
increases
mitophagy-related
proteins
(PINK1
Parkin)
via
AMPK/SIRT1
to
prevent
chickens.
