Brain-muscle communication prevents muscle aging by maintaining daily physiology

Science, Год журнала: 2024, Номер 384(6695), С. 563 - 572

Опубликована: Май 2, 2024

A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions importance of intratissue networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic module involving central peripheral (muscle) clock. Reconstituting brain-muscle sufficient to preserve fundamental homeostatic functions prevent aging. However, achieving whole requires contributions from other clocks. Mechanistically, acts as gatekeeper, selectively suppressing detrimental signals while integrating important functions. Our research reveals interplay between clocks function underscores impact eating patterns on these interactions.

Язык: Английский

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The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis

Cell stem cell, Год журнала: 2024, Номер 31(6), С. 834 - 849.e4

Опубликована: Май 2, 2024

Язык: Английский

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The Relationship between Circadian Rhythm and Cancer Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5846 - 5846

Опубликована: Май 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Язык: Английский

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The role of the circadian clock in the development, progression, and treatment of non‐alcoholic fatty liver disease

Acta Physiologica, Год журнала: 2023, Номер 237(3)

Опубликована: Янв. 5, 2023

The circadian clock comprises a cellular endogenous timing system coordinating the alignment of physiological processes with geophysical time. Disruption rhythms has been associated several metabolic diseases. In this review, we focus on liver as major tissue and one most well-studied organs regard to regulation. We summarize current knowledge about role local systemic clocks in regulating biological functions liver. discuss how disruption influences development non-alcoholic fatty disease (NAFLD) steatohepatitis (NASH). also critically evaluate whether NAFLD/NASH may turn result chronodisruption. last chapter focuses potential roles prevention treatment interaction NASH drug candidates clocks. It becomes increasingly clear that paying attention open new avenues for optimization therapies provide interesting targets these prevalent disorders.

Язык: Английский

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Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice

Aging Cell, Год журнала: 2023, Номер 22(5)

Опубликована: Март 26, 2023

Abstract Accumulation of senescent cells (SNCs) with a senescence‐associated secretory phenotype (SASP) has been implicated as major source chronic sterile inflammation leading to many age‐related pathologies. Herein, we provide evidence that bifunctional immunotherapeutic, HCW9218, capabilities neutralizing TGF‐β and stimulating immune cells, can be safely administered systemically reduce SNCs alleviate SASP in mice. In the diabetic db/db mouse model, subcutaneous administration HCW9218 reduced islet β resulting improved glucose tolerance, insulin resistance, aging index. naturally aged mice, durably level SASP, lower expression pro‐inflammatory genes peripheral organs. treatment also reverted pattern key regulatory circadian gene mice levels observed young impacted associated metabolism fibrosis liver. Single‐nucleus RNA Sequencing analysis further revealed differentially changed transcriptomic landscape hepatocyte subtypes involving metabolic, signaling, cell‐cycle, pathways Long‐term survival studies showed physical performance without compromising health span Thus, represents novel immunotherapeutic approach clinically promising new class senotherapeutic agents targeting cellular diseases.

Язык: Английский

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Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 5, 2024

Abstract Thyroid hormones (THs) are important regulators of systemic energy metabolism. In the liver, they stimulate lipid and cholesterol turnover increase bioavailability. It is still unknown how TH state interacts with circadian clock, another regulator We addressed this question using a mouse model hypothyroidism performed analyses. Low levels decreased locomotor activity, food intake, body temperature mostly in active phase. Concurrently, liver transcriptome profiling showed only subtle effects compared to elevated conditions. Comparative revealed alterations mesor, amplitude, phase transcript livers low-TH mice. Genes associated uptake, biosynthesis, bile acid secretion reduced mesor. Increased serum were identified, respectively. Combining data from low- high-TH conditions allowed identification 516 genes mesor changes as molecular markers state. explored these created an expression panel that assesses time-of-day dependent manner. Our findings suggest has low action under physiological Circadian reveals potential

Язык: Английский

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Dynamic Tracking of Biological Processes Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Окт. 8, 2024

Biological processes are characterized by dynamic and elaborate temporal patterns driven the interplay of genes, proteins, cellular components that crucial for adaptation to changing environments. This complexity spans from molecular organismal scales, necessitating their real-time monitoring tracking unravel active fuel living systems enable early disease detection, personalized medicine, drug development. Single-walled carbon nanotubes (SWCNTs), with unique physicochemical optical properties, have emerged as promising tools such processes. perspective highlights key properties SWCNTs make them ideal monitoring. Subsequently, it surveys studies utilizing track biological phenomena across hierarchical levels─from molecules cells, tissues, organs, whole organisms─acknowledging pivotal role in advancing this field. Finally, review outlines challenges future directions, aiming expand frontier using SWCNTs, contributing deeper insights novel applications biomedicine.

Язык: Английский

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CBC‐Clock Theory of Life – Integration of cellular circadian clocks and cellular sentience is essential for cognitive basis of life

BioEssays, Год журнала: 2021, Номер 43(10)

Опубликована: Авг. 11, 2021

Cellular circadian clocks represent ancient anticipatory systems which co-evolved with the first cells to safeguard their survival. Cyanobacteria one of most cells, having essentially invented photosynthesis together redox-based cellular some 2.7 billion years ago. Bioelectricity phenomena, based on redox homeostasis associated electron transfers in membranes and within protein complexes inserted excitable membranes, play important roles, not only anesthetics-sensitive sentience (awareness environment), but also coupling single into tissues organs unitary multicellular organisms. This integration basis is an essential feature cognitive CBC-Clock life.

Язык: Английский

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Eat, sleep, repeat – endocrine regulation of behavioural circadian rhythms

FEBS Journal, Год журнала: 2021, Номер 289(21), С. 6543 - 6558

Опубликована: Июль 6, 2021

The adaptation of organisms to a rhythmic environment is mediated by an internal timing system termed the circadian clock. In mammals, molecular clocks are found in all tissues and organs. This clock network regulates release many hormones, which turn influence some most vital behavioural functions. Sleep-wake cycles under strict control with strong hormones such as melatonin, cortisol others. Food intake, contrast, receives modulation through leptin, ghrelin, insulin orexin. A third output covered this review mating bonding behaviours, regulated rhythms steroid oxytocin. Together, these data emphasize pervasive on outputs its mediation endocrine networks.

Язык: Английский

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Energy Balance and Control of Body Weight: Possible Effects of Meal Timing and Circadian Rhythm Dysregulation

Nutrients, Год журнала: 2021, Номер 13(9), С. 3276 - 3276

Опубликована: Сен. 19, 2021

Conservation of the energy equilibrium can be considered a dynamic process and variations one component (energy intake or expenditure) cause biological and/or behavioral compensatory changes in other part system. The interplay between demand caloric appears designed to guarantee an adequate food supply variable life contexts. circadian rhythm plays major role systemic homeostasis by acting as “timekeeper” human body, under control central peripheral clocks that regulate many physiological functions such sleep, hunger body temperature. Clock-associated processes anticipate daily demands imposed environment, being synchronized ideal physiologic conditions. Factors interfere with expected demand, including distribution macronutrients, physical activity light exposure, may disrupt harmony predicted actual behavior. Such desynchronization favor development wide range disease-related processes, obesity its comorbidities. Evidence has been provided main components 24-h EE affected disruption rhythm. sleep pattern, meal timing composition could mediate these effects. An increased understanding crosstalk balance shed on pathophysiologic mechanisms underlying weight gain, which eventually lead design effective strategies fight pandemic.

Язык: Английский

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