Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse Childhood Experiences DOI Creative Commons

Rodney R. Dietert,

Janice M. Dietert

Microorganisms, Journal Year: 2022, Volume and Issue: 10(2), P. 229 - 229

Published: Jan. 21, 2022

Adverse childhood experiences (ACEs), which can include child trafficking, are known to program children for disrupted biological cycles, premature aging, microbiome dysbiosis, immune-inflammatory misregulation, and chronic disease multimorbidity. To date, the has not been a major focus of deprogramming efforts despite its emerging role in every aspect ACE-related dysbiosis dysfunction. This article examines: (1) utility incorporating microorganism-based, anti-aging approaches combat ACE-programmed diseases (also as noncommunicable conditions, NCDs) (2) regulation core systems biology cycles that affect NCD comorbid risk. In this review, microbiota influence over three key cyclic rhythms (circadian sleep cycle, lifespan/longevity cycle) well tissue inflammation oxidative stress discussed an opportunity deprogram ACE-driven disorders. Microbiota, particularly those gut, have shown host-microbe interactions regulating circadian clock, quality, immune function/senescence, inflammation. The microimmunosome is one several targets gut regulation. Furthermore, correcting misregulated increased protecting telomere length extending what become healthspan. review concludes reverse tragedy NCDs managing human holobiont should routine part healthcare preventative medicine across life course.

Language: Английский

Brain-muscle communication prevents muscle aging by maintaining daily physiology DOI
Arun Kumar, Mireia Vaca-Dempere, Thomas Mortimer

et al.

Science, Journal Year: 2024, Volume and Issue: 384(6695), P. 563 - 572

Published: May 2, 2024

A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions importance of intratissue networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic module involving central peripheral (muscle) clock. Reconstituting brain-muscle sufficient to preserve fundamental homeostatic functions prevent aging. However, achieving whole requires contributions from other clocks. Mechanistically, acts as gatekeeper, selectively suppressing detrimental signals while integrating important functions. Our research reveals interplay between clocks function underscores impact eating patterns on these interactions.

Language: Английский

Citations

20
The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis DOI
Thomas Mortimer, Valentina M. Zinna,

Muge Atalay

et al.

Cell stem cell, Journal Year: 2024, Volume and Issue: 31(6), P. 834 - 849.e4

Published: May 2, 2024

Language: Английский

Citations

12
The Relationship between Circadian Rhythm and Cancer Disease DOI Open Access
Camelia Munteanu,

Sabina Turti,

Larisa Achim

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5846 - 5846

Published: May 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Language: Английский

Citations

12
The role of the circadian clock in the development, progression, and treatment of non‐alcoholic fatty liver disease DOI
Leonardo Vinícius Monteiro de Assis, Münevver Demir, Henrik Oster

et al.

Acta Physiologica, Journal Year: 2023, Volume and Issue: 237(3)

Published: Jan. 5, 2023

The circadian clock comprises a cellular endogenous timing system coordinating the alignment of physiological processes with geophysical time. Disruption rhythms has been associated several metabolic diseases. In this review, we focus on liver as major tissue and one most well-studied organs regard to regulation. We summarize current knowledge about role local systemic clocks in regulating biological functions liver. discuss how disruption influences development non-alcoholic fatty disease (NAFLD) steatohepatitis (NASH). also critically evaluate whether NAFLD/NASH may turn result chronodisruption. last chapter focuses potential roles prevention treatment interaction NASH drug candidates clocks. It becomes increasingly clear that paying attention open new avenues for optimization therapies provide interesting targets these prevalent disorders.

Language: Английский

Citations

17
Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice DOI Creative Commons
Niraj Shrestha,

Pallavi Chaturvedi,

Xiaoyun Zhu

et al.

Aging Cell, Journal Year: 2023, Volume and Issue: 22(5)

Published: March 26, 2023

Abstract Accumulation of senescent cells (SNCs) with a senescence‐associated secretory phenotype (SASP) has been implicated as major source chronic sterile inflammation leading to many age‐related pathologies. Herein, we provide evidence that bifunctional immunotherapeutic, HCW9218, capabilities neutralizing TGF‐β and stimulating immune cells, can be safely administered systemically reduce SNCs alleviate SASP in mice. In the diabetic db/db mouse model, subcutaneous administration HCW9218 reduced islet β resulting improved glucose tolerance, insulin resistance, aging index. naturally aged mice, durably level SASP, lower expression pro‐inflammatory genes peripheral organs. treatment also reverted pattern key regulatory circadian gene mice levels observed young impacted associated metabolism fibrosis liver. Single‐nucleus RNA Sequencing analysis further revealed differentially changed transcriptomic landscape hepatocyte subtypes involving metabolic, signaling, cell‐cycle, pathways Long‐term survival studies showed physical performance without compromising health span Thus, represents novel immunotherapeutic approach clinically promising new class senotherapeutic agents targeting cellular diseases.

Language: Английский

Citations

17
Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice DOI Creative Commons
Leonardo Vinícius Monteiro de Assis, Lisbeth Harder, José Thalles Jocelino Gomes de Lacerda

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 5, 2024

Abstract Thyroid hormones (THs) are important regulators of systemic energy metabolism. In the liver, they stimulate lipid and cholesterol turnover increase bioavailability. It is still unknown how TH state interacts with circadian clock, another regulator We addressed this question using a mouse model hypothyroidism performed analyses. Low levels decreased locomotor activity, food intake, body temperature mostly in active phase. Concurrently, liver transcriptome profiling showed only subtle effects compared to elevated conditions. Comparative revealed alterations mesor, amplitude, phase transcript livers low-TH mice. Genes associated uptake, biosynthesis, bile acid secretion reduced mesor. Increased serum were identified, respectively. Combining data from low- high-TH conditions allowed identification 516 genes mesor changes as molecular markers state. explored these created an expression panel that assesses time-of-day dependent manner. Our findings suggest has low action under physiological Circadian reveals potential

Language: Английский

Citations

7
Dynamic Tracking of Biological Processes Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes DOI Creative Commons
Srestha Basu, Adi Hendler‐Neumark, Gili Bisker

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Biological processes are characterized by dynamic and elaborate temporal patterns driven the interplay of genes, proteins, cellular components that crucial for adaptation to changing environments. This complexity spans from molecular organismal scales, necessitating their real-time monitoring tracking unravel active fuel living systems enable early disease detection, personalized medicine, drug development. Single-walled carbon nanotubes (SWCNTs), with unique physicochemical optical properties, have emerged as promising tools such processes. perspective highlights key properties SWCNTs make them ideal monitoring. Subsequently, it surveys studies utilizing track biological phenomena across hierarchical levels─from molecules cells, tissues, organs, whole organisms─acknowledging pivotal role in advancing this field. Finally, review outlines challenges future directions, aiming expand frontier using SWCNTs, contributing deeper insights novel applications biomedicine.

Language: Английский

Citations

6
CBC‐Clock Theory of Life – Integration of cellular circadian clocks and cellular sentience is essential for cognitive basis of life DOI Creative Commons
František Baluška, Arthur S. Reber

BioEssays, Journal Year: 2021, Volume and Issue: 43(10)

Published: Aug. 11, 2021

Cellular circadian clocks represent ancient anticipatory systems which co-evolved with the first cells to safeguard their survival. Cyanobacteria one of most cells, having essentially invented photosynthesis together redox-based cellular some 2.7 billion years ago. Bioelectricity phenomena, based on redox homeostasis associated electron transfers in membranes and within protein complexes inserted excitable membranes, play important roles, not only anesthetics-sensitive sentience (awareness environment), but also coupling single into tissues organs unitary multicellular organisms. This integration basis is an essential feature cognitive CBC-Clock life.

Language: Английский

Citations

37
Energy Balance and Control of Body Weight: Possible Effects of Meal Timing and Circadian Rhythm Dysregulation DOI Open Access
Alessio Basolo,

Susanna Bechi Genzano,

Paolo Piaggi

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(9), P. 3276 - 3276

Published: Sept. 19, 2021

Conservation of the energy equilibrium can be considered a dynamic process and variations one component (energy intake or expenditure) cause biological and/or behavioral compensatory changes in other part system. The interplay between demand caloric appears designed to guarantee an adequate food supply variable life contexts. circadian rhythm plays major role systemic homeostasis by acting as “timekeeper” human body, under control central peripheral clocks that regulate many physiological functions such sleep, hunger body temperature. Clock-associated processes anticipate daily demands imposed environment, being synchronized ideal physiologic conditions. Factors interfere with expected demand, including distribution macronutrients, physical activity light exposure, may disrupt harmony predicted actual behavior. Such desynchronization favor development wide range disease-related processes, obesity its comorbidities. Evidence has been provided main components 24-h EE affected disruption rhythm. sleep pattern, meal timing composition could mediate these effects. An increased understanding crosstalk balance shed on pathophysiologic mechanisms underlying weight gain, which eventually lead design effective strategies fight pandemic.

Language: Английский

Citations

36
Eat, sleep, repeat – endocrine regulation of behavioural circadian rhythms DOI Open Access

Sarah Koop,

Henrik Oster

FEBS Journal, Journal Year: 2021, Volume and Issue: 289(21), P. 6543 - 6558

Published: July 6, 2021

The adaptation of organisms to a rhythmic environment is mediated by an internal timing system termed the circadian clock. In mammals, molecular clocks are found in all tissues and organs. This clock network regulates release many hormones, which turn influence some most vital behavioural functions. Sleep-wake cycles under strict control with strong hormones such as melatonin, cortisol others. Food intake, contrast, receives modulation through leptin, ghrelin, insulin orexin. A third output covered this review mating bonding behaviours, regulated rhythms steroid oxytocin. Together, these data emphasize pervasive on outputs its mediation endocrine networks.

Language: Английский

Citations

35