Context-specific regulation of extracellular vesicle biogenesis and cargo selection

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 24(7), С. 454 - 476

Опубликована: Фев. 10, 2023

Язык: Английский

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Emerging mechanisms of obesity-associated immune dysfunction

Nature Reviews Endocrinology, Год журнала: 2023, Номер 20(3), С. 136 - 148

Опубликована: Дек. 21, 2023

Язык: Английский

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Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease

Medicina, Год журнала: 2023, Номер 59(3), С. 561 - 561

Опубликована: Март 13, 2023

Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily increasing globally and seems to parallel the prevalence of obesity. It consists cluster risk factors which traditionally includes obesity hyperlipidemia, hyperinsulinemia, hypertension, hyperglycemia. These four core are associated with insulin resistance (IR) and, importantly, MetS known increase for developing cerebrocardiovascular disease type 2 diabetes mellitus. The had its early origins in IR X. undergone numerous name changes, additional variables being added over years; however, it remained as worldwide past three decades. This overview continues add novel insights suggests leptin hyperleptinemia, aberrant mitochondrial stress reactive oxygen species (ROS), impaired folate-mediated one-carbon metabolism hyperhomocysteinemia, vascular stiffening, microalbuminuria, visceral adipose tissues extracellular vesicle exosomes be list variables. Notably, role dysfunctional activated endothelium deficient nitric oxide bioavailability along attenuated endothelial glycocalyx, inflammation, systemic metainflammation, important ROS interactome discussed. With new knowledge regarding comes possibility findings through further research.

Язык: Английский

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Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Bioactive Materials, Год журнала: 2022, Номер 22, С. 423 - 452

Опубликована: Окт. 20, 2022

Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain affects patient's quality of life. However, currently, there lack effective early diagnosis treatment. Although stem cells can promote cartilage repair treat OA, problems such as immune rejection tumorigenicity persist. Extracellular vesicles (EVs) transmit genetic information from donor mediate intercellular communication, which considered functional paracrine factor cells. Increasing evidences suggest EVs may play an essential complex role in the pathogenesis, diagnosis, treatment OA. Here, we introduced OA progression by influencing inflammation, metabolism, aging. Next, discussed blood, synovial fluid, joint-related for diagnosis. Moreover, outlined potential modified unmodified their combination with biomaterials therapy. Finally, discuss deficiencies put forward prospects challenges related to application field

Язык: Английский

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Molecular Mechanisms of Western Diet-Induced Obesity and Obesity-Related Carcinogenesis—A Narrative Review

Metabolites, Год журнала: 2023, Номер 13(5), С. 675 - 675

Опубликована: Май 21, 2023

The present study aims to provide a narrative review of the molecular mechanisms Western diet-induced obesity and obesity-related carcinogenesis. A literature search Cochrane Library, Embase Pubmed databases, Google Scholar grey was conducted. Most that induce are also involved in twelve Hallmarks Cancer, with fundamental process being consumption highly processed, energy-dense diet deposition fat white adipose tissue liver. generation crown-like structures, macrophages surrounding senescent or necrotic adipocytes hepatocytes, leads perpetual state chronic inflammation, oxidative stress, hyperinsulinaemia, aromatase activity, activation oncogenic pathways loss normal homeostasis. Metabolic reprogramming, epithelial mesenchymal transition, HIF-1α signalling, angiogenesis host immune-surveillance particularly important. Obesity-associated carcinogenesis is closely related metabolic syndrome, hypoxia, visceral dysfunction, oestrogen synthesis detrimental cytokine, adipokine exosomal miRNA release. This important pathogenesis oestrogen-sensitive cancers, including breast, endometrial, ovarian thyroid cancer, but ‘non-hormonal’ obesity-associated cancers such as cardio-oesophageal, colorectal, renal, pancreatic, gallbladder hepatocellular adenocarcinoma. Effective weight interventions may improve future incidence overall cancer.

Язык: Английский

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Role of Adipose Tissue Derived Exosomes in Metabolic Disease

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Май 4, 2022

Adipose tissues perform physiological functions such as energy storage and endocrine, whose dysfunction will lead to severe metabolic disorders. Accumulating evidences show that exosomes can meditate communications between different by transporting nucleic acids, proteins other biological factors. More importantly, secreted adipose tissue function critical contributing factors elucidate specific mechanisms in disturbance obesity, inflammation diabetes etc. is the major source of circulating exosomal miRNAs. miRNA from not only altered patients with disease, but also result an increase organ talk. Here we have reviewed latest progress on role derived roles Moreover, current obstacles hindering exosome-based therapeutic strategies been discussed.

Язык: Английский

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Adipose-Derived Extracellular Vesicles: Systemic Messengers and Metabolic Regulators in Health and Disease

Frontiers in Physiology, Год журнала: 2022, Номер 13

Опубликована: Фев. 23, 2022

Adipose tissue is comprised of a heterogeneous population cells that co-operate to perform diverse physiological roles including endocrine-related functions. The endocrine role adipose enables it communicate nutritional and health cues other organs, such as the liver, muscle, brain, in order regulate appetite whole body metabolism. dysfunction, which often observed obesity, associated with changes secretome, can subsequently contribute disease pathology. Indeed, secreted bioactive factors released from metabolic homeostasis likely play causal disease; however, what constitutes entirety secretome still poorly understood. Recent advances nanotechnology have advanced this field substantially led identification small, particles known extracellular vesicles (EVs). These small nano-sized lipid envelopes are by most cell types capable systemically delivering molecules, nucleic acids, proteins, lipids. EVs interact target deliver specific cargo then elicit effects various tissues throughout body. has recently been shown secrete periphery maintain homeostasis, or under certain pathological conditions, drive disease. In review, we discuss current landscape tissue-derived EVs, focus on their regulation

Язык: Английский

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Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease

Опубликована: Фев. 7, 2023

Abstract Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily increasing globally and seems to parallel the prevalence of obesity. It consists cluster risk factors, which traditionally includes obesity hyperlipidemia, hyperinsulinemia, hypertension, hyperglycemia. These four core factors are associated with insulin resistance (IR) importantly, MetS known increase for developing cerebrocardiovascular disease type 2 diabetes mellitus. The had its early origins in IR X. undergone numerous name changes additional variables being added over years; however, it still remains worldwide past three decades. This overview continues add novel insights suggests leptin hyperleptinemia, aberrant mitochondrial stress reactive oxygen species (ROS), impaired folate-mediated one-carbon metabolism hyperhomocysteinemia, vascular stiffening, microalbuminuria, visceral adipose tissues extracellular vesicle exosomes be list variables. Notably, role dysfunctional activated endothelium deficient nitric oxide bioavailability along attenuated endothelial glycocalyx, inflammation, systemic metainflammation, important ROS interactome discussed. With new knowledge regarding MetS, comes possibility findings through further research.

Язык: Английский

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Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 24, 2024

Abstract The cargo content in small extracellular vesicles (sEVs) changes under pathological conditions. Our data shows that obesity, matrix protein 1 (ECM1) levels are significantly increased circulating sEVs, which is dependent on integrin-β2. Knockdown of integrin-β2 does not affect cellular ECM1 but reduces the sEVs released by these cells. In breast cancer (BC), overexpressing increases metalloproteinase 3 (MMP3) and S100A/B levels. Interestingly, purified from high-fat diet-induced obesity mice (D-sEVs) deliver more to BC cells compared control diet-fed mice. Consequently, secrete protein, promotes cell invasion migration. D-sEVs treatment also enhances ECM1-mediated metastasis growth mouse models, as evidenced elevated tumor MMP3 S100A/B. study reveals a mechanism suggests sEV-based strategies for treating obesity-associated BC.

Язык: Английский

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Role of micro‐RNAs associated with adipose‐derived extracellular vesicles in metabolic disorders

Obesity Reviews, Год журнала: 2024, Номер 25(7)

Опубликована: Апрель 15, 2024

Micro-RNAs have emerged as important actors in the onset of metabolic disorders including obesity or type 2 diabetes. Particularly, several micro-RNAs are known to be key modulators lipid metabolism, glucose homeostasis, feeding behavior. Interestingly, role extracellular vesicles containing micro-RNAs, especially adipose-derived vesicles, well-documented endocrine signals and disease biomarkers. However, on different tissues is highly related micro-RNA content. This review provides recent data about potential involvement vesicle-containing diseases.

Язык: Английский

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