The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways

Genes and Immunity, Год журнала: 2024, Номер 25(4), С. 277 - 296

Опубликована: Июнь 22, 2024

Abstract MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene expression, microRNAs adjust targeting specific genes and signaling pathways. This review focuses on impact of inflammatory pathways triggered during injury highlights inflammation, playing critical pathophysiology Dysregulated expression contributes pathogenesis injury, therefore offers an opportunity restore homeostasis improve patient outcomes. Understanding complex network immunoregulatory could provide novel therapeutic interventions aimed at attenuating excessive inflammation preserving tissue integrity.

Язык: Английский

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Extracellular Vesicles as Communicators of Senescence in Musculoskeletal Aging

JBMR Plus, Год журнала: 2022, Номер 6(11)

Опубликована: Сен. 30, 2022

Extracellular vesicles (EVs), including exosomes and microvesicles, are released by numerous cell types. EVs now acknowledged as playing a critical role in cell-cell communication healthy aging well age-related diseases. Recently it was shown that senescence, key hallmark of aging, increases the secretion EVs. Moreover, can transport proteins microRNAs (miRNAs) components senescence-associated secretory phenotype (SASP). Here we review evidence SASP-related miRNAs involved musculoskeletal degeneration with aging. Specifically, senescence-related elevated skeletal muscle myocytes fibro-adipogenic progenitor cells disuse atrophy, respectively. Many these same detected from synovial fluid patients osteoarthritis, contribute to cartilage degeneration. Finally, secreted bone marrow-derived stem (stromal) impacting neighboring hematopoietic circulating blood. The miRNA mir-34a, which is known target Wnt Notch pathways survival factors Sirt1 Bcl2, human animal subjects loss, osteoarthritis. These findings suggest suppressing EV-derived, miRNAs, such miR-34a, or increasing levels competing endogenous long noncoding RNAs, MALAT1 inhibit may help improve function © 2022 Authors. JBMR Plus published Wiley Periodicals LLC on behalf American Society for Bone Mineral Research.

Язык: Английский

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Vascular calcification in CKD: New insights into its mechanisms

Journal of Cellular Physiology, Год журнала: 2023, Номер 238(6), С. 1160 - 1182

Опубликована: Июнь 1, 2023

Vascular calcification (VC) is a common complication of chronic kidney disease (CKD) and contributes to an increased risk cardiovascular morbidity mortality. However, effective therapies are still unavailable at present. It has been well established that VC associated with CKD not passive process calcium phosphate deposition, but actively regulated cell-mediated shares many similarities bone formation. Additionally, numerous studies have suggested patients specific factors contributors the development VC, such as hyperphosphatemia, uremic toxins, oxidative stress inflammation. Although research efforts in past decade greatly improved our knowledge multiple mechanisms involved CKD-related questions remain unanswered. Moreover, from demonstrated epigenetic modifications abnormalities, DNA methylation, histone noncoding RNAs, play important role regulation VC. This review seeks provide overview pathophysiological molecular CKD, mainly focusing on involvement initiation progression aim develop promising for events future.

Язык: Английский

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Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems

Cardiovascular Diabetology, Год журнала: 2023, Номер 22(1)

Опубликована: Май 24, 2023

Diabetes mellitus, a group of metabolic disorders characterized by high levels blood glucose caused insulin defect or impairment, is major risk factor for cardiovascular diseases and related mortality. Patients with diabetes experience state chronic intermittent hyperglycemia resulting in damage to the vasculature, leading micro- macro-vascular diseases. These conditions are associated low-grade inflammation accelerated atherosclerosis. Several classes leukocytes have been implicated diabetic impairment. Although molecular pathways through which elicits an inflammatory response attracted significant attention, how they contribute altering homeostasis still incompletely understood. In this respect, non-coding RNAs (ncRNAs) largely under-investigated class transcripts that may play fundamental role. This review article gathers current knowledge on function ncRNAs crosstalk between immune cells context complications, highlighting influence biological sex such mechanisms exploring potential role as biomarkers targets treatments. The discussion closes offering overview involved increased suffered patients facing Sars-CoV-2 infection.

Язык: Английский

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Regulatory RNAs in immunosenescence

Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(3)

Опубликована: Март 1, 2024

Abstract Background Immunosenescence is a multifactorial stress response to different intrinsic and extrinsic insults that cause immune deterioration accompanied by genomic or epigenomic perturbations. It now widely recognized genes proteins contributing in the process of immunosenescence are regulated various noncoding (nc) RNAs, including microRNAs (miRNAs), long ncRNAs, circular RNAs. Aims This review article aimed evaluate regulatore RNAs roles immunosenescence. Methods We analyzed publications were focusing on regulatory several aspects Results In setting, ncRNAs have been found play at both transcriptional post‐transcriptional levels. These factors cooperate regulate initiation gene expression programs sustaining senescence phenotype proinflammatory responses. Conclusion complex with pivotal alterations function occurring age. The extensive network drive immunosenescence‐related features mainly directed variety such as miRNAs, lncRNAs, circRNAs. Latest findings about regulation innate adaptive cells well their role pathways, provide better understanding

Язык: Английский

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microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician’s Perspective

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(24), С. 15645 - 15645

Опубликована: Дек. 9, 2022

Ischemic stroke (IS) related to atherosclerosis of large arteries is one the leading causes mortality and disability in developed countries. Atherosclerotic internal carotid artery stenosis (ICAS) contributes 20% all cerebral ischemia cases. Nowadays, prevention treatment measures aim at controlling risk factors, or interventional (surgical endovascular) management mature occlusive lesions. There a definite lack established circulating biomarkers which, once modulated, could prevent development atherosclerosis, consequently carotid-artery-related IS. Recent studies emphasize that microRNA (miRNA) are emerging particles potentially play pivotal role this approach. some research on association between expression small non-coding microRNAs with plaque vulnerability. However, data remain inconsistent. In addition, major atherosclerotic were conducted cell culture animal models; very few humans, whereas accumulating evidence demonstrates it cannot be automatically extrapolated processes humans. Therefore, paper aims review current knowledge how miRNA participate process formation rupture, as well occurrence. We discuss potential target used prognostic therapeutic tool.

Язык: Английский

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γ‐glutamylcysteine alleviates insulin resistance and hepatic steatosis by regulating adenylate cyclase and IGF‐1R/IRS1/PI3K/Akt signaling pathways

The Journal of Nutritional Biochemistry, Год журнала: 2023, Номер 119, С. 109404 - 109404

Опубликована: Июнь 11, 2023

Язык: Английский

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Vascular Aging and Atherosclerosis: A Perspective on Aging

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Vascular aging (VA) is recognized as a pivotal factor in the development and progression of atherosclerosis (AS). Although various epidemiological clinical research has demonstrated an intimate connection between AS, candidate mechanisms still require thorough examination. This review adopts aging-centric perspective to deepen comprehension intricate relationship biological aging, vascular cell senescence, AS. Various aging-related physiological factors influence physical system's reactions, including oxygen radicals, inflammation, lipids, angiotensin II, mechanical forces, glucose levels, insulin resistance. These cause endothelial dysfunction, barrier damage, sclerosis, inflammation for VA promote AS via distinct or shared pathways. Furthermore, increase senescent cells inside tissues, caused by genetic dysregulation, secretome changes, epigenetic modifications, might be primary VA.

Язык: Английский

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Micro-RNA profiles of pathology and resilience in posterior cingulate cortex of cognitively intact elders

Brain Communications, Год журнала: 2024, Номер 6(2)

Опубликована: Янв. 1, 2024

Abstract The posterior cingulate cortex (PCC) is a key hub of the default mode network underlying autobiographical memory retrieval, which falters early in progression Alzheimer’s disease (AD). We recently performed RNA sequencing post-mortem PCC tissue samples from 26 elderly Rush Religious Orders Study participants who came to autopsy with an ante-mortem diagnosis no cognitive impairment but collectively displayed range Braak I–IV neurofibrillary tangle stages. Notably, cognitively unimpaired subjects displaying high stages may represent resilience AD pathology. Transcriptomic data revealed elevated synaptic and ATP-related gene expression Stages III/IV compared I/II, suggesting these pathways be related resilience. also mined profiles for small non-coding micro-RNAs (miRNAs), regulate mRNA stability underexplored potential mechanism through fine-tuning within complex cellular networks. Twelve miRNAs were identified as differentially expressed between I/II III/IV. However, extent levels all associated subject demographics, neuropsychological test performance and/or neuropathological diagnostic criteria this cohort was not explored. Here, we report that total 667 are significantly (rho > 0.38, P < 0.05) variables. There significant positive correlations miRNA age, perceptual orientation speed. By contrast, higher correlated negatively semantic episodic memory. Higher 15 lower I–II 47 III–IV, additional mechanistic influences Pathway analysis showed enrichment operating lysine degradation fatty acid synthesis metabolism. Finally, demonstrated 12 resilience-related versus predicted mRNAs amyloid processing, tau inflammation. In summary, demonstrate dynamic state wherein differential intact elders. posit relationships inform transcriptional alterations relevant protective (resilience) or pathogenic (pre-clinical prodromal) responses pathogenesis thus therapeutic targets.

Язык: Английский

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Inflammaging, a targetable pathway for preventing cardiovascular diseases

Cardiovascular Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Abstract Inflammageing, characterized by persistent chronic inflammation in older adults, has emerged as a critical factor linked to age-related diseases, such cardiovascular diseases (CVDs), metabolic disorders, and cognitive decline, which collectively contribute the leading causes of death globally. Elevated levels cytokines, chemokines, other inflammatory mediators characterize inflammageing serve indicators biological age. Among inflammageing, deterioration immune system, mitochondrial dysfunction, dysbiosis, accumulation DAMPs, together with genetic or epigenetic factors, not only CVD but also conditions. This review examines consequences particularly its implications for atherosclerosis heart failure preserved ejection fraction explores potential strategies mitigate it onset CVD.

Язык: Английский

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