Altered Choroid Plexus Volume and Association with Migraine Pathophysiology DOI Creative Commons

Jianmei Xiong,

Mengqi Liu,

Huanbo Liu

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 4, 2023

Abstract Background Although compelling evidences suggest that cortical spreading depression and the trigeminovascular system activation are main mechanisms underlying migraigenesis, it remains “a nearly complete mystery of how migraine starts”. Direct evidence choroid plexus structures involved in presumed peripheral-central interaction is exceptionally scarce and, thus, which demands further attention. Objectives Our objective to assess volumetric changes quantitatively episodic chronic patients versus age sex compared normal controls, elucidate pathophysiology. Methods Total sixty-five participants including 18 patients, 16 31 controls were recruited underwent a brain MR examination with 3.0T strength between September 2021 May 2023. The ventricles was segmented fully automatically on T1-weighted MRI sequences using FreeSurfer (Version 5.3.0) software. Lateral ventricular volume expressed as ratio ipsilateral lateral ventricle (CP/LV). Group differences assessed cross-sectionally. accuracy CP/LV for prediction receiver operating characteristic curves analysis. Results Patients more anxious depressive, heavier headache burden impaired cognitive ability. Statistical analysis revealed group right side. ration decreased but size increased prolongation disease duration. side able differentiate from area under ROC curve (AUC) 0.696 (95% CI: 0.550–0.818, sensitivity 100%, specificity 46.8%, cut-off value 0.0741, P < 0.05). diagnostic efficacy marginally higher distinguishing AUC 0.715(95% 0.536–0.856, 50%, 94.4% 0.0725, Conclusion finding suggested dynamic alteration pathogenesis migraine. associated can be used potential imaging biomarker diagnosis.

Язык: Английский

Human cerebellar organoids with functional Purkinje cells DOI Creative Commons
Alexander Atamian, Marcella Birtele, Negar Hosseini

и другие.

Cell stem cell, Год журнала: 2024, Номер 31(1), С. 39 - 51.e6

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

41
Formation and function of multiciliated cells DOI Creative Commons
Qian Lyu, Qingchao Li, Jun Zhou

и другие.

The Journal of Cell Biology, Год журнала: 2023, Номер 223(1)

Опубликована: Ноя. 30, 2023

In vertebrates, multiciliated cells (MCCs) are terminally differentiated that line the airway tracts, brain ventricles, and reproductive ducts. Each MCC contains dozens to hundreds of motile cilia beat in a synchronized manner drive fluid flow across epithelia, dysfunction which is associated with group human diseases referred as ciliopathies, such primary dyskinesia. Given dynamic complex process multiciliogenesis, biological events essential for forming multiple comparatively unelucidated. Thanks advancements genetic tools, omics technologies, structural biology, significant progress has been achieved past decade understanding molecular mechanism underlying regulation formation. this review, we discuss recent studies ex vivo culture animal models, summarize current knowledge particularly highlight advances their implications.

Язык: Английский

Процитировано

23
Microglia innate immune response contributes to the antiviral defense and blood–CSF barrier function in human choroid plexus organoids during HSV‐1 infection DOI Creative Commons

Haowen Qiao,

Yuanpu Chiu,

Xinyan Liang

и другие.

Journal of Medical Virology, Год журнала: 2023, Номер 95(2)

Опубликована: Янв. 6, 2023

Abstract The choroid plexus (ChP) is the source of cerebrospinal fluid (CSF). ChP–CSF system not only provides necessary cushion for brain but also works as a sink waste clearance. During sepsis, pathogens and host immune cells can weaken ChP barrier enter brain, causing cerebral dysfunctions known sepsis‐associated encephalophagy. Here, we used human organoid (ChPO) to model herpes simplex virus type 1 (HSV‐1) infection found epithelial were highly susceptible HSV‐1. Since current ChPO lacks functional innate component, particularly microglia, next developed new microglia‐containing model, microglia could effectively limit HSV‐1 protect in ChPOs. Furthermore, cyclic GMP‐AMP synthase (cGAS)–STING pathway its downstream interferon response essential, cGAS inhibitor RU.512 or STING H‐151 abolished antiviral function worsened organoids. These results together indicated that cGAS–STING coordinates contributes treating sepsis related neurological conditions.

Язык: Английский

Процитировано

20
Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum DOI Creative Commons
Jiwei Jiang,

Zhizheng Zhuo,

Anxin Wang

и другие.

Alzheimer s Research & Therapy, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 3, 2024

Enlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer's disease (AD) and inversely correlated cognitive performance. However, its clinical diagnostic predictive value, mechanisms by which ChP impacts the AD continuum remain unclear.

Язык: Английский

Процитировано

9
Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma DOI Creative Commons

Abhirami Visvanathan,

Olivier Saulnier, Chuan Chen

и другие.

Cell, Год журнала: 2024, Номер 187(17), С. 4733 - 4750.e26

Опубликована: Июль 5, 2024

We identify a population of Protogenin-positive (PRTG

Язык: Английский

Процитировано

9
IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions DOI Open Access

Anton Shkundin,

Angelos Halaris

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(5), С. 488 - 488

Опубликована: Май 3, 2024

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological psychiatric health. It exerts a profound effect on immune cell activation brain function, suggesting potential roles in both neuroprotection neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation disease progression. Additionally, CXCL8 gene polymorphisms can alter production, leading differences susceptibility, progression, severity across populations. levels vary among neuropsychiatric conditions, demonstrating sensitivity psychosocial stressors severity. be detected blood circulation, cerebrospinal fluid (CSF), urine, making it promising candidate for broad-spectrum biomarker. This review highlights the need further research diverse effects of associated implications personalized medicine. A thorough understanding its complex role could lead development more effective treatment strategies conditions.

Язык: Английский

Процитировано

7
Engineering choroid plexus-on-a-chip with oscillatory flow for modeling brain metastasis DOI Creative Commons
Jungeun Lim, Stephen Rhee,

Hyeri Choi

и другие.

Materials Today Bio, Год журнала: 2023, Номер 22, С. 100773 - 100773

Опубликована: Авг. 19, 2023

The human brain choroid plexus (ChP) is a highly organized secretory tissue with complex vascular system and epithelial layers in the ventricles of brain. ChP body's principal source cerebrospinal fluid (CSF); it also functions as barrier to separate blood from CSF, because movement CSF through body pulsatile nature. Thus far, has been challenging recreate specialized features dynamics physiologically relevant microenvironment. In this study, we recapitulated structure by developing microfluidic chip accordance established design rules. Furthermore, used image processing analysis mimic flow within rlcking system; hydrogel containing laminin extracellular matrix (ECM). Human cells were cultured ChP-on-a-chip vivo-like dynamic an engineered ECM. key characteristics capillaries, layer, secreted components recreated adjusted microenvironment our ChP-on-a-chip. drug screening capabilities device observed responses breast cancer that had spread ChP. immune device, demonstrated motility cytotoxic effects macrophages, which are most prevalent Our will facilitate elucidation pathophysiology support development therapeutics treat cancers have metastasized into

Язык: Английский

Процитировано

15
A Review of Cerebrospinal Fluid Circulation and the Pathogenesis of Congenital Hydrocephalus DOI Creative Commons
Mingzhao Zhang,

Xiangjun Hu,

Lifeng Wang

и другие.

Neurochemical Research, Год журнала: 2024, Номер 49(5), С. 1123 - 1136

Опубликована: Фев. 10, 2024

Abstract The brain’s ventricles are filled with a colorless fluid known as cerebrospinal (CSF). When there is an excessive accumulation of CSF in the ventricles, it can result high intracranial pressure, ventricular enlargement, and compression surrounding brain tissue, leading to potential damage. This condition referred hydrocephalus. Hydrocephalus classified into two categories: congenital acquired. Congenital hydrocephalus (CH) poses significant challenges for affected children their families, particularly resource-poor countries. Recognizing psychological economic impacts crucial developing interventions support systems that help alleviate distress burden faced by these families. As our understanding production circulation improves, we gaining clearer insights causes CH. In this article, will summarize current knowledge regarding pathways underlying main CH include abnormalities FoxJ1 pathway cilia, dysfunctions choroid plexus transporter Na + -K -2Cl - contransporter isoform 1, developmental cerebral cortex, structural within brain. Understanding indeed advancing research effective treatment strategies. review, findings from existing studies on propose directions further condition.

Язык: Английский

Процитировано

5
Volume enlargement of the choroid plexus and brain ventricles in drug-naïve, first-episode major depressive disorder DOI Creative Commons

Gaku Hayasaki,

Enkhmurun Chibaatar, Keita Watanabe

и другие.

Journal of Affective Disorders, Год журнала: 2024, Номер 354, С. 719 - 724

Опубликована: Март 22, 2024

We investigated volumetric alterations in the bilateral choroid plexus (ChP) and brain ventricles of patients during their first episode major depressive disorder (MDD) prior to antidepressant treatment. Seventy-one first-episode drug-naïve with MDD seventy-four healthy control (HC) subjects were recruited. MRI data obtained, ChP ventricle volumes evaluated using segmentation, based on adaptive multiscale expectation maximization method. One-way multivariate analysis covariance was used calculate differences between groups, partial Pearson correlation analyses investigate relationship ventricles. First-episode showed enlarged ChP, lateral (LV), third compared HCs. The volume positively correlated LV ventricle, but not fourth MDD, whereas it all four did observe significant correlations ventricles, HAMD scores, or symptom severity. Our study populations differed age sex we extensively measure amount neuroinflammation blood, include a functional assessment, nor evaluate other neural comorbidities neuropsychiatric conditions. extends existing research suggest that illness-related enlargement antidepressant-naïve may serve as trait measure.

Язык: Английский

Процитировано

3
Aberrant choroid plexus formation drives the development of treatment-related brain toxicity DOI Creative Commons
Tamara Bender,

Esther Schickel,

Celine Schielke

и другие.

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Фев. 22, 2025

Abstract Brain tumors are commonly treated with radiotherapy, but the efficacy of treatment is limited by its toxicity to normal tissue including post-irradiation contrast enhanced lesions often linked necrosis. The poorly understood mechanisms behind such brain were studied using cerebral organoids. Here we show that irradiation organoids leads dose-dependent growth retardation and formation liquid-filled cavities not correlated Instead, radiation-induced changes comprise an enhancement cortical hem markers, altered neuroepithelial stem cell differentiation, increase ZO1 + /AQP1 /CLDN3 -choroid plexus (CP)-like structures accompanied upregulation IGF2 mRNA, known be expressed in CP cerebrospinal fluid. differentiation attributed WNT/BMP signaling pathways. We conclude aberrant can involved providing additional strategies for possible countermeasures.

Язык: Английский

Процитировано

0