High expression of SIGLEC7 may promote M2-type macrophage polarization leading to adverse prognosis in glioma patients DOI Creative Commons

Wenhao An,

Changyuan Ren,

Lei Yuan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 15, 2024

Introduction Gliomas are the most common primary intracranial tumors, known for their high invasiveness and destructiveness. Sialic acid-binding immunoglobulin-like lectin 7 (SIGLEC7) is present in various immune cells, especially macrophages, significantly affects homeostasis cancer cell response. However, research on role prognostic impact of SIGLEC7 glioma patients currently limited. Methods We utilized transcriptomic data from 702 The Cancer Genome Atlas (TCGA) 693 Chinese Glioma (CGGA), along with clinical samples we collected, to comprehensively investigate expression patterns, biological functions, value. focused its glioma-related responses infiltration analyzed at single-cell level. Finally, validated gliomas through tissue experiments. Results was increased malignant characteristics. Survival analysis indicated that had lower survival rates. Gene function revealed primarily involved inflammatory strongly negatively correlated tumor-associated regulation. Additionally, checkpoints positively SIGLEC7, clearly demonstrated a significant positive correlation between M2 macrophage levels. Single-cell analysis, experiments, confirmed enhances polarization towards phenotype, thereby promoting immunosuppressive effects macrophages. Cox regression establishment prediction models an unfavorable factor patients. Discussion High predicts poor prognosis closely associated macrophages tumor environment. In future, may become promising target immunotherapy.

Language: Английский

Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance DOI Creative Commons
Milad Ashrafizadeh,

Jingyuan Dai,

Pedram Torabian

et al.

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: May 11, 2024

The non-coding RNAs comprise a large part of human genome lack capacity in encoding functional proteins. Among various members RNAs, the circular (circRNAs) have been importance pathogenesis diseases, especially cancer. circRNAs unique closed loop structure and due to their stability, they are potential diagnostic prognostic factors increasing evidences highlighted role modulation proliferation metastasis cancer cells. On other hand, has responsible for up 90% cancer-related deaths patients, requiring more investigation regarding underlying mechanisms modulating this mechanism. EMT enhances invasion tumor cells, can trigger resistance therapy. cells demonstrate dynamic changes during including transformation from epithelial phenotype into mesenchymal increase N-cadherin vimentin levels. process is reversible its reprogramming disrupt progression aim current review understanding interaction cancers such beyond regulation affect response chemotherapy radiotherapy. onco-suppressor inhibit EMT, while tumor-promoting mediate acceleration carcinogenesis. Moreover, EMT-inducing transcription be controlled by different tumors.

Language: Английский

Citations

59
Versatile function of NF-ĸB in inflammation and cancer DOI Creative Commons
Qiang Ma, Shuai Hao, Weilong Hong

et al.

Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 16, 2024

Abstract Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune systems, significantly influencing various physiological processes such as cell proliferation, migration, differentiation, survival, stemness. The function of NF-ĸB cancer progression response to chemotherapy has gained increasing attention. This review highlights the inflammation control, biological mechanisms, therapeutic implications treatment. is instrumental altering release inflammatory factors TNF-α, IL-6, IL-1β, which are key regulation carcinogenesis. Specifically, conditions including colitis, upregulation can intensify inflammation, potentially leading development colorectal cancer. Its pivotal extends regulating tumor microenvironment, impacting components macrophages, fibroblasts, T cells, natural killer cells. influences tumorigenesis dampen anti-tumor responses. Additionally, modulates death notably by inhibiting apoptosis ferroptosis. It also dual stimulating or suppressing autophagy cancers. Beyond these functions, controlling stem fostering angiogenesis, metastatic potential through EMT induction, reducing sensitivity radiotherapy. Given its oncogenic capabilities, research focused on products small molecule compounds that suppress NF-ĸB, offering promising avenues for therapy.

Language: Английский

Citations

24
Complex roles of autophagy in cancer development, immune evasion, and drug resistance DOI

Xuegang Niu,

Qi Sheng You, Kejun Hou

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 78, P. 101170 - 101170

Published: Nov. 15, 2024

Language: Английский

Citations

18
Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

Citations

16
Oral Cancer Stem Cells: A Comprehensive Review of Key Drivers of Treatment Resistance and Tumor Recurrence DOI

P J Nagarathna,

Santosh Patil, Vishnu Priya Veeraraghavan

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177222 - 177222

Published: Jan. 1, 2025

Language: Английский

Citations

2
Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy DOI
Songsong Wu,

Zhumin Cao,

Ruinan Lu

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Triple-Negative Breast Cancer Progression and Drug Resistance in the Context of Epithelial–Mesenchymal Transition DOI Open Access
Ewa Błaszczak, Paulina Miziak, Adrian Odrzywolski

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 228 - 228

Published: Jan. 12, 2025

Triple-negative breast cancer (TNBC) is one of the most difficult subtypes to treat due its distinct clinical and molecular characteristics. Patients with TNBC face a high recurrence rate, an increased risk metastasis, lower overall survival compared other subtypes. Despite advancements in targeted therapies, traditional chemotherapy (primarily using platinum compounds taxanes) continues be standard treatment for TNBC, often limited long-term efficacy. tumors are heterogeneous, displaying diverse mutation profile considerable chromosomal instability, which complicates therapeutic interventions. The development chemoresistance frequently associated process epithelial–mesenchymal transition (EMT), during epithelial tumor cells acquire mesenchymal-like phenotype. This shift enhances metastatic potential, while simultaneously reducing effectiveness chemotherapeutics. It has also been suggested that EMT plays central role stem cells. Hence, there growing interest exploring small-molecule inhibitors target as future strategy overcoming resistance improving outcomes patients TNBC. review focuses on progression drug emphasis these processes. We present TNBC-specific EMT-related features, key protein markers, various signaling pathways involved. discuss important mechanisms factors related within context EMT, highlighting improve patients’ outcomes.

Language: Английский

Citations

2
Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients DOI Creative Commons

Jae-Ghi Lee,

Il‐Kyu Park, Hannah Lee

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 27, 2025

This study aimed to investigate the clinical significance of E-cadherin expression levels in colorectal cancer tissues and explore relationship between tumor node metastasis (TNM) stage. The goal was establish a more accurate prognostic prediction for patients by analyzing alongside TNM staging. examined dividing them into groups based on levels. It then assessed their 5-year event-free survival (EFS) disease-specific (DSS) hazard ratios (HRs). Additionally, prognosis analyzed combining with staging, particularly focusing stages III IV. E-cadherinLow group had significantly worse outcomes, HRs 2.30 EFS 2.76 DSS compared E-cadherinHigh group. When combined stage III/IV, showed poor prognosis, 1.93 2.35 those at same Low are associated decreased patients. Combining staging provides precise patient survival, potentially guiding personalized treatment strategies.

Language: Английский

Citations

2
Metastasis and chemoresistance in breast cancer: Crucial function of ZEB1/2 proteins DOI

Seyed Mohammad Doodmani,

Majid Safari, Mohammadarian Akbari

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 267, P. 155838 - 155838

Published: Feb. 11, 2025

Language: Английский

Citations

2
Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis DOI Creative Commons
Xiaohao Wang, Zechao Qu, Song‐Chuan Zhao

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Oct. 28, 2024

Abstract Osteoblasts are mainly derived from mesenchymal stem cells in the bone marrow. These can differentiate into osteoblasts, which have functions of secreting matrix, promoting formation, and participating remodeling. The abnormality osteoblasts cause a variety bone-related diseases, including osteoporosis, delayed fracture healing, skeletal deformities. In recent years, with side effects caused by application PTH drugs, biphosphonate calmodulin people carried out more in-depth research on mechanism osteoblast differentiation, actively looking for natural compounds treatment osteoporosis. Wnt/β-catenin signaling pathway is considered to be one important pathways has become an target pathway, whether its activation enhanced or expression weakened, will diseases tumors. This review summarize effect differentiation correlation between related proteins human diseases. At same time, latest progress targeting against osteoporosis summarized.

Language: Английский

Citations

10