The Journal of Biochemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Cancer
stem
cells
(CSCs)
play
a
central
role
in
cancer
progression,
therapy
resistance,
and
disease
recurrence.
With
the
use
of
quadruple-mutant
mouse
intestinal
organoid
model
single-cell
RNA-sequencing
analysis,
we
have
now
identified
glycosylphosphatidylinositol-specific
phospholipase
D1
(GPLD1),
an
enzyme
that
catalyzes
cleavage
glycosylphosphatidylinositol
(GPI)
anchors
membrane
proteins,
as
marker
slowly
cycling
CSCs.
Ablation
Gpld1+
combination
with
5-fluorouracil
treatment
greatly
attenuated
cell
viability
regrowth
organoids.
In
addition,
serine
protease
8
(PRSS8)
key
substrate
GPLD1
human
colorectal
cells.
cleaves
GPI
anchor
PRSS8
thereby
mediates
release
from
plasma
membrane,
resulting
activation
Wnt
signaling
promotion
epithelial-mesenchymal
transition
(EMT)
Pharmacological
inhibition
suppressed
activity
EMT
association
upregulation
amount
functional
at
membrane.
Our
findings
suggest
targeting
might
contribute
to
new
therapeutic
strategy
is
based
on
suppression
EMT-related
progression
driven
by
Cellular and Molecular Life Sciences,
Journal Year:
2024,
Volume and Issue:
81(1)
Published: May 11, 2024
The
non-coding
RNAs
comprise
a
large
part
of
human
genome
lack
capacity
in
encoding
functional
proteins.
Among
various
members
RNAs,
the
circular
(circRNAs)
have
been
importance
pathogenesis
diseases,
especially
cancer.
circRNAs
unique
closed
loop
structure
and
due
to
their
stability,
they
are
potential
diagnostic
prognostic
factors
increasing
evidences
highlighted
role
modulation
proliferation
metastasis
cancer
cells.
On
other
hand,
has
responsible
for
up
90%
cancer-related
deaths
patients,
requiring
more
investigation
regarding
underlying
mechanisms
modulating
this
mechanism.
EMT
enhances
invasion
tumor
cells,
can
trigger
resistance
therapy.
cells
demonstrate
dynamic
changes
during
including
transformation
from
epithelial
phenotype
into
mesenchymal
increase
N-cadherin
vimentin
levels.
process
is
reversible
its
reprogramming
disrupt
progression
aim
current
review
understanding
interaction
cancers
such
beyond
regulation
affect
response
chemotherapy
radiotherapy.
onco-suppressor
inhibit
EMT,
while
tumor-promoting
mediate
acceleration
carcinogenesis.
Moreover,
EMT-inducing
transcription
be
controlled
by
different
tumors.
Experimental Hematology and Oncology,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: July 16, 2024
Abstract
Nuclear
factor-kappaB
(NF-ĸB)
plays
a
crucial
role
in
both
innate
and
adaptive
immune
systems,
significantly
influencing
various
physiological
processes
such
as
cell
proliferation,
migration,
differentiation,
survival,
stemness.
The
function
of
NF-ĸB
cancer
progression
response
to
chemotherapy
has
gained
increasing
attention.
This
review
highlights
the
inflammation
control,
biological
mechanisms,
therapeutic
implications
treatment.
is
instrumental
altering
release
inflammatory
factors
TNF-α,
IL-6,
IL-1β,
which
are
key
regulation
carcinogenesis.
Specifically,
conditions
including
colitis,
upregulation
can
intensify
inflammation,
potentially
leading
development
colorectal
cancer.
Its
pivotal
extends
regulating
tumor
microenvironment,
impacting
components
macrophages,
fibroblasts,
T
cells,
natural
killer
cells.
influences
tumorigenesis
dampen
anti-tumor
responses.
Additionally,
modulates
death
notably
by
inhibiting
apoptosis
ferroptosis.
It
also
dual
stimulating
or
suppressing
autophagy
cancers.
Beyond
these
functions,
controlling
stem
fostering
angiogenesis,
metastatic
potential
through
EMT
induction,
reducing
sensitivity
radiotherapy.
Given
its
oncogenic
capabilities,
research
focused
on
products
small
molecule
compounds
that
suppress
NF-ĸB,
offering
promising
avenues
for
therapy.
Journal of Hematology & Oncology,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 27, 2025
This
study
aimed
to
investigate
the
clinical
significance
of
E-cadherin
expression
levels
in
colorectal
cancer
tissues
and
explore
relationship
between
tumor
node
metastasis
(TNM)
stage.
The
goal
was
establish
a
more
accurate
prognostic
prediction
for
patients
by
analyzing
alongside
TNM
staging.
examined
dividing
them
into
groups
based
on
levels.
It
then
assessed
their
5-year
event-free
survival
(EFS)
disease-specific
(DSS)
hazard
ratios
(HRs).
Additionally,
prognosis
analyzed
combining
with
staging,
particularly
focusing
stages
III
IV.
E-cadherinLow
group
had
significantly
worse
outcomes,
HRs
2.30
EFS
2.76
DSS
compared
E-cadherinHigh
group.
When
combined
stage
III/IV,
showed
poor
prognosis,
1.93
2.35
those
at
same
Low
are
associated
decreased
patients.
Combining
staging
provides
precise
patient
survival,
potentially
guiding
personalized
treatment
strategies.
Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
30(1)
Published: Oct. 28, 2024
Abstract
Osteoblasts
are
mainly
derived
from
mesenchymal
stem
cells
in
the
bone
marrow.
These
can
differentiate
into
osteoblasts,
which
have
functions
of
secreting
matrix,
promoting
formation,
and
participating
remodeling.
The
abnormality
osteoblasts
cause
a
variety
bone-related
diseases,
including
osteoporosis,
delayed
fracture
healing,
skeletal
deformities.
In
recent
years,
with
side
effects
caused
by
application
PTH
drugs,
biphosphonate
calmodulin
people
carried
out
more
in-depth
research
on
mechanism
osteoblast
differentiation,
actively
looking
for
natural
compounds
treatment
osteoporosis.
Wnt/β-catenin
signaling
pathway
is
considered
to
be
one
important
pathways
has
become
an
target
pathway,
whether
its
activation
enhanced
or
expression
weakened,
will
diseases
tumors.
This
review
summarize
effect
differentiation
correlation
between
related
proteins
human
diseases.
At
same
time,
latest
progress
targeting
against
osteoporosis
summarized.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 215 - 238
Published: Jan. 1, 2025
Background:
Ovarian
cancer
is
difficult
to
detect
in
its
early
stages,
and
it
has
a
high
potential
for
invasion
metastasis,
along
with
rate
of
recurrence.
These
factors
contribute
the
poor
prognosis
reduced
survival
times
patients
this
disease.
The
effectiveness
conventional
chemoradiotherapy
remains
limited.
Nano-particles,
as
novel
drug
delivery
system,
have
significant
improving
therapeutic
efficacy
overcoming
these
challenges.
Methods:
According
expression
level
matrix
metalloproteinase-2
(MMP-2)
tumor
microenvironment,
MMP-2
responsive
nano-particles
(PVGLIG-MTX-D/T-NMs)
containing
docetaxel
triptolide
were
prepared
by
thin-film
dispersion
method.
synergistic
effect
between
was
systematically
investigated,
ratio
two
drugs
optimized,
physicochemical
properties
their
ability
inhibit
ovarian
cell
growth
metastasis
evaluated
vitro
vivo.
Results:
PVGLIG-MTX-D/T-NMs
enhanced
targeting,
stability,
bioavailability
drug,
while
reducing
dose
toxicity.
In
addition,
regulating
levels
E-Cadherin,
N-Cadherin,
metalloproteinases
(MMPs),
hypoxia-inducible
factor
1-alpha
(HIF-1α),
vascular
endothelial
(VEGF),
exhibited
an
inhibitory
on
epithelial-mesenchymal
transformation
(EMT)
angiogenesis,
effectively
inhibited
cells.
Conclusion:
achieved
passive
targeting
sites
enhancing
permeability
retention
(EPR)
effects.
Subsequently,
uptake
cells
responsiveness
modification
methotrexate
ligands.
By
invasion-
metastasis-related
proteins
tissues,
affected
EMT
process,
suppressed
malignant
cancer.
findings
provided
new
direction
further
exploration
tumor-targeted
therapy.
Keywords:
nano-drug
docetaxel,
triptolide,
epithelial
mesenchymal
transition,
angiogenesis
Expert Reviews in Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
27
Published: Jan. 1, 2025
Abstract
Despite
the
emergence
of
first
human
papillomavirus
vaccine,
incidence
cervical
cancer
is
still
responsible
for
more
than
350,000
deaths
yearly.
Over
past
decade,
ecto-5′-nucleotidase
(CD73/5′-NT)
and
extracellular
adenosine
(ADO)
signalling
has
been
subject
many
investigations
to
target
progression.
In
general,
adenosinergic
axis
linked
tumourigenic
effects.
However,
CD73
can
play
contradictory
effects,
probably
dependent
on
tumour
type,
microenvironment
stage,
thus
being
in
some
circumstances,
inversely
related
We
herein
reviewed
pathophysiological
function
performed
silico
analysis
main
components
tissues
compared
non-tumour
cervix
tissue.
Our
data
showed
that
NT5E
gene,
encoded
CD73,
hypermethylated,
leading
a
decreased
expression
cells
normal
cells.
Consequently,
high
availability
ADO
cytoplasmatic/extracellular
leads
its
conversion
AMP
by
ADK,
culminating
global
hypermethylation.
Therefore,
epigenetic
modulation
may
reveal
new
role
cancer.
