RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Сен. 28, 2024

Язык: Английский

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Edge of RNA m6A modification on LINE-1 retrotransposons in central nervous system: merely a transcriptional control?

Epigenomics, Год журнала: 2025, Номер unknown, С. 1 - 3

Опубликована: Март 18, 2025

KEYWORDS: LINE-1epitranscriptomem6A RNA modificationcancerneurodegeneration, cytokine-induced killer cell therapycentral nervous systemInverse associationglioblastoma multiforme, transposable elements

Язык: Английский

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Functional role of autophagy in testicular and ovarian steroidogenesis

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Май 17, 2024

Autophagy is an evolutionarily conserved cellular recycling process that maintains homeostasis. Despite extensive research in endocrine contexts, the role of autophagy ovarian and testicular steroidogenesis remains elusive. The significant testosterone production suggests potential treatments for conditions like oligospermia azoospermia. Further, influence folliculogenesis, ovulation, luteal development emphasizes its importance improved fertility reproductive health. Thus, investigating gonadal cells clinically significant. Understanding these processes could transform disorders, enhancing health longevity. Herein, we provide functional to date, highlighting modulation impact on hormone synthesis, follicle development, therapies.

Язык: Английский

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Expression pattern of RNA demethylase ALKBH5 in fetal and adult human testis

Tissue and Cell, Год журнала: 2025, Номер unknown, С. 102901 - 102901

Опубликована: Апрель 1, 2025

Язык: Английский

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m6A-modified MIR670HG suppresses tumor liver metastasis through enhancing Kupffer cell phagocytosis

Cellular and Molecular Life Sciences, Год журнала: 2025, Номер 82(1)

Опубликована: Апрель 28, 2025

Liver metastases are frequently observed in various malignancies, including hepatocellular carcinoma, colorectal cancer, pancreatic and melanoma. As hepatic resident macrophages, Kupffer cells play a crucial role resisting liver metastasis by phagocytosing clearing invading tumor cells. However, the molecular mechanisms regulating cell phagocytosis remain largely unknown. Here, we demonstrate that MIR670 host gene (MIR670HG) significantly suppresses enhancing of CD24 was identified as downstream target critical mediator MIR670HG promoting inhibiting metastasis. Further investigations revealed interacts with m6A reader FXR1 DNA 5-methylcytosine dioxygenase TET1 an modification-dependent manner. These interactions reduce binding to promoter, leading increased methylation at promoter transcriptional suppression CD24. Mutation modification site abolishes ability suppress CD24, promote phagocytosis, inhibit In clinical tissue samples, expression negatively correlated findings suggest m6A-modified promotes epigenetically downregulating

Язык: Английский

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RNA methylation in retrotransposon control

Trends in Genetics, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

N6-methyladenosine (m6A) regulates retrotransposon activity, shifting between repression and activation across different species developmental stages. It promotes RNA decay, sequestration, or stability, influencing genome integrity, adaptation, disease. This article explores the dual role of m6A in control, highlighting its evolutionary significance regulation cellular differentiation.

Язык: Английский

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Nuclear m6A modification regulates satellite transcription and chromosome segregation

Nature Chemical Biology, Год журнала: 2025, Номер unknown

Опубликована: Май 22, 2025

Язык: Английский

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METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 27, 2024

Язык: Английский

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