METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence DOI Creative Commons
Su Dong, Jiajia Zhang,

Yushan Fu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 27, 2024

Language: Английский

RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy DOI Creative Commons

Jun-Xiao Shi,

Zhichao Zhang, Hao-zan Yin

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 28, 2024

Language: Английский

Citations

8
Functional role of autophagy in testicular and ovarian steroidogenesis DOI Creative Commons
Ali Afzal, Yue Zhang, Hanan Afzal

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: May 17, 2024

Autophagy is an evolutionarily conserved cellular recycling process that maintains homeostasis. Despite extensive research in endocrine contexts, the role of autophagy ovarian and testicular steroidogenesis remains elusive. The significant testosterone production suggests potential treatments for conditions like oligospermia azoospermia. Further, influence folliculogenesis, ovulation, luteal development emphasizes its importance improved fertility reproductive health. Thus, investigating gonadal cells clinically significant. Understanding these processes could transform disorders, enhancing health longevity. Herein, we provide functional to date, highlighting modulation impact on hormone synthesis, follicle development, therapies.

Language: Английский

Citations

4
Edge of RNA m6A modification on LINE-1 retrotransposons in central nervous system: merely a transcriptional control? DOI Creative Commons
Amit Sharma, Tikam Chand Dakal,

Ingo Schmidt‐Wolf

et al.

Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: March 18, 2025

KEYWORDS: LINE-1epitranscriptomem6A RNA modificationcancerneurodegeneration, cytokine-induced killer cell therapycentral nervous systemInverse associationglioblastoma multiforme, transposable elements

Language: Английский

Citations

0
Expression pattern of RNA demethylase ALKBH5 in fetal and adult human testis DOI
Fang Fang, Ke Ni

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102901 - 102901

Published: April 1, 2025

Language: Английский

Citations

0
m6A-modified MIR670HG suppresses tumor liver metastasis through enhancing Kupffer cell phagocytosis DOI Creative Commons

Wan-peng Lu,

Yong-da Liu,

Zhifa Zhang

et al.

Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)

Published: April 28, 2025

Liver metastases are frequently observed in various malignancies, including hepatocellular carcinoma, colorectal cancer, pancreatic and melanoma. As hepatic resident macrophages, Kupffer cells play a crucial role resisting liver metastasis by phagocytosing clearing invading tumor cells. However, the molecular mechanisms regulating cell phagocytosis remain largely unknown. Here, we demonstrate that MIR670 host gene (MIR670HG) significantly suppresses enhancing of CD24 was identified as downstream target critical mediator MIR670HG promoting inhibiting metastasis. Further investigations revealed interacts with m6A reader FXR1 DNA 5-methylcytosine dioxygenase TET1 an modification-dependent manner. These interactions reduce binding to promoter, leading increased methylation at promoter transcriptional suppression CD24. Mutation modification site abolishes ability suppress CD24, promote phagocytosis, inhibit In clinical tissue samples, expression negatively correlated findings suggest m6A-modified promotes epigenetically downregulating

Language: Английский

Citations

0
METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence DOI Creative Commons
Su Dong, Jiajia Zhang,

Yushan Fu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 27, 2024

Language: Английский

Citations

2